Serum Levels of Lipids, Lipoproteins and Paraoxonase Activity in Pre-Eclampsia

Abstract

Serum paraoxonase 1 (PON1) activity and the oxidation of lipoproteins were investigated in 35 women with pre-eclampsia and in 35 healthy control women with normal pregnancies. Blood pressure, body mass index (BMI), serum levels of total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and lipoprotein (a) (Lp[a]), and PON1 activity were assessed. There were no significant between-group differences in subject age, gestational age at diagnosis of pre-eclampsia, BMI, serum total cholesterol, triglycerides, LDL and ApoB levels. Mean systolic and diastolic blood pressures and serum Lp(a) were significantly higher in subjects with pre-eclampsia than in controls. Mean serum HDL, ApoA1 and PON1 activity were significantly lower in subjects with pre-eclampsia compared with controls. In conclusion, lipids and oxidized lipoproteins may play important roles in the pathogenesis of pre-eclampsia.

In the Pre-eclamp sia and Normotensive Patient- Lipid Profile Study

“…Serum HDL-cholesterol level was significantly lower in pre-eclamptic than that of control normal pregnancy (p<0.001). This result was similar to other studies that serum HDL-cholesterol level was significantly lower in pre-eclamptic than that of control normal pregnancy 1,6,10,11,12,18 .…”

Lipoprotein (a): impact by ethnicity and environmental and medical conditions

“…There are many contradictory reports in findings have been reported by others (117)(118)(119)(120)(121)(122)(123) (124)(125)(126)(127). In pregnan cies complicated with preeclampsia or hypertension, a sig nificantly elevated Lp(a) concentration has been observed in some studies (128)(129)(130)(131)(132)(133)(134)(135)(136), but not consistently (120,121,(137)(138)(139)(140)(141)(142)(143). Of note, the majority of these studies did not assess apo(a) isoform sizes.…”

Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia

“…Increased plasma apoE polymorphisms have been reported in women with pre-eclampsia (17,18), however findings relating to apoA1 measurements in pre-eclampsia are conflicting (19,20). To-date, it is not known whether AIBP is expressed in the placenta or altered in pre-eclampsia.…”