Serum levels of MMP-3 and cathepsin K in patients with ankylosing spondylitis: Effect of TNFα antagonist therapy

Serum matrix metalloproteinases-3 levels in patients with ankylosing spondylitis

“…In agreement with our study, De Seny et al (2008) revealed that MMP-3 serum level apparently increased in patients with AS when compared to healthy subjects and the serum levels of MMP-3 combined with C-reactive protein (CRP) can also reflect the disease activity of AS. In contrast, Wendling et al (2008) indicated that serum MMP-3 level could not be a serum marker for the progression of AS.…”

“…Two additional studies were removed after further assessment. Finally, 13 case-control studies were analyzed in the current meta-analysis (Yang et al, 2004b;Chen et al, 2006;de Seny et al, 2008;Lin et al, 2008;Sun and Yang, 2008;Wendling et al, 2008;Wang et al, 2010;Shen et al, 2011;Ma and Yang, 2012;Soliman et al, 2012;Dhir et al, 2013;Sha and Lei, 2013;Hou et al, 2014).…”

“…serum MMP-3 levels in the development and progression of AS, implying that detection of serum MMP-3 levels may be clinically utilized in the evaluation of disease activity in AS (Wendling et al, 2008;Hou et al, 2014). However, other related documents indicated no correlation between serum MMP-3 levels and AS pathogenesis (Lin et al, 2008;Soliman et al, 2012).…”

Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy

“…However, certain MMPs are regulated by glucocorticoids via interference with the binding of the transcription factor activator protein-1, the major enhancer factor of the collagenase promoter (Jonat et al, 1990). Infliximab and other TNF-␣ antagonists can also act on the ECM by stimulating MMP activity and, therefore, ECM degradation (Wendling et al, 2008;Di Sabatino et al, 2009). Nonsteroidal anti-inflammatory drugs, which primarily inhibit cyclooxygenase enzymes and thereby prevent the synthesis of prostanoids, are able to ameliorate fibrotic processes via influencing TGF-␤ synthesis .…”

Laboratory Biomarkers for Ankylosing Spondylitis

“…Уровень катепсина К по-вышен в мононуклеарных и фибробластоподобных клет-ках больных АС [63], в то время как сывороточная концен-трация данного маркера не отличатся от таковой у здоро-вых лиц [64].…”