Serum levels of mu-opioid receptor according to menstrual cycle phases are associated with postoperative pain and opioid consumption in laparoscopic gynecological surgeries: a prospective observational study

Miniksar, Ökkeş Hakan; Onat, Taylan; Göçmen, Ayşe Yeşim; Honca, Mehtap

doi:10.1007/s11845-022-03146-z

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…The influence of sex hormones represents a significant source of variability in response to opioids [ 15 , 16 ]. The effect of opioid analgesia was significantly greater in the follicular phase than in the luteal phase [ 17 , 18 ]. However, the results are not always consistent.…”

Section: The Effect Of Gonadal Steroids On Opioid-mediated Analgesiamentioning

confidence: 99%

The role of gonadal hormones in regulating opioid antinociception

Xu,

Jin,

Wang

et al. 2024

Annals of Medicine

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Opioids are the most prescribed drugs for the alleviation of pain. Both clinical and preclinical studies have reported strong evidence for sex-related divergence regarding opioid analgesia. There is an increasing amount of evidence indicating that gonadal hormones regulate the analgesic efficacy of opioids. This review presents an overview of the importance of gonadal steroids in modulating opioid analgesic responsiveness and focuses on elaborating what is currently known regarding the underlyingmechanism. We sought to identify the link between gonadal hormones and the effect of oipiod antinociception.

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Section: The Effect Of Gonadal Steroids On Opioid-mediated Analgesiamentioning

confidence: 99%

The role of gonadal hormones in regulating opioid antinociception

Xu,

Jin,

Wang

et al. 2024

Annals of Medicine

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Endogenous opiates and behavior: 2023

Bodnar

2024

Peptides

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Sex differences in opioid response: a role for the gut microbiome?

Han,

Manners,

Robinson

2024

Front. Pharmacol.

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Opioid drugs have been long known to induce different responses in males compared to females, however, the molecular mechanisms underlying these effects are yet to be fully characterized. Recent studies have established a link between the gut microbiome and behavioral responses to opioids. Chronic opioid use is associated with gut dysbiosis, or microbiome disruptions, which is thought to contribute to altered opioid analgesia and reward processing. Gut microbiome composition and functioning have also been demonstrated to be influenced by sex hormones. Despite this, there is currently very little work investigating whether sex differences in the gut microbiome mediate sex-dependent responses to opioids, highlighting a critical gap in the literature. Here, we briefly review the supporting evidence implicating a potential role for the gut microbiome in regulating sexually dimorphic opioid response and identify areas for future research.

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Serum levels of mu-opioid receptor according to menstrual cycle phases are associated with postoperative pain and opioid consumption in laparoscopic gynecological surgeries: a prospective observational study

Cited by 3 publications

References 20 publications

The role of gonadal hormones in regulating opioid antinociception

The role of gonadal hormones in regulating opioid antinociception

Endogenous opiates and behavior: 2023

Sex differences in opioid response: a role for the gut microbiome?

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