Serum Levels of Natriuretic Peptides in Children before and after Treatment for an Atrial Septal Defect, a Patent Ductus Arteriosus, and a Coarctation of the Aorta—A Prospective Study

Eerola, Anneli; Jokinen, Eero; Boldt, Talvikki; Mattila, Ilkka; Pihkala, Jaana

doi:10.1155/2010/674575

Cited by 11 publications

(5 citation statements)

References 48 publications

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“…Our study reports no difference in NT-pro-BNP levels between repaired CoA patients and controls. This is in accordance with a recently published study by Eerola et al in which NT-pro-BNP levels in CoA patients, although higher than controls before and 6 months after repair, were similar at one year follow up [35]. This may be explained by the fact that left ventricular pressure overload is not expected to be significant in these patients since they do not present with serious hypertension, their NYHA class was not affected and LV dimension and function were within normal range.…”

Section: Neurohormonal and Immune Activation Late After Coa Repairsupporting

confidence: 93%

Neurohormonal activity and vascular properties late after aortic coarctation repair

Moutafi

Alissafi

Chamakou

et al. 2012

International Journal of Cardiology

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Section: Neurohormonal and Immune Activation Late After Coa Repairsupporting

confidence: 93%

Neurohormonal activity and vascular properties late after aortic coarctation repair

Moutafi

Alissafi

Chamakou

et al. 2012

International Journal of Cardiology

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“…11 Eerola et al performed another study to investigate the association between peptide hormone levels and echocardiographic results, at 6 months and 12 months observation in ASD and coarctation of the aorta patients. 26 They reported decreased left ventricle diameters at six months after closure by about 20%, but in our study, left ventricular diameters decreased about 25% at three months after closure.…”

Section: Discussioncontrasting

confidence: 75%

NT-proBNP level and left ventricle diameters before and after transcatheter closure of PDA and VSD

Kusmira¹,

Nova

Bakri

2018

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Background Amino-terminal pro-B-type natriuretic peptide (NT-proBNP) levels before and after transcatheter closure may correlate with changes in left ventricular internal diameter end diastole (LVIDd) and end systole (LVIDs). Patent ductus arteriosus (PDA) and ventricular septal defect (VSD) are structural abnormalities which effects cardiac hypertrophy. Cardiac muscle stretching decreases after closure, followed by reduced left ventricle diameters and decreased NT-proBNP levels. Objective To analyze for possible correlations between NT-proBNP levels and left ventricle diameters before and after transcatheter closure. Methods Subjects were PDA and VSD patients who underwent transcatheter closure in the Pediatrics Department of dr. Moh Hoesin Hospital, Palembang, South Sumatera, from May 2016 to March 2017. Measurement of NT-proBNP levels and echocardiography were performed before closure, as well as one and three months after closure. Results There were 34 subjects (15 girls) with median age of 91.5 months. Median NT-proBNP levels were significantly reduced after closure: before closure 111.7pg/mL, one month after closure 62pg/mL, and three months after closure 39 pg/mL (P<0.05). Median LVIDd and LVIDs were also significantly reduced after closure [LVIDd: 39.5mm before, 34.5mm one mo after, and 32.5mm 3 mo after (P<0.05); LVIDs: 23.9mm before, 20.5mm 1 mo after, and 20.0mm 3 mo after (P<0.05)]. At one month after closure, there was a moderate positive correlation between NT-proBNP levels and LVIDd (r=0.432; P=0.011), but no correlation with LVIDs (r=0.287; P=0.100). At three months after closure, there was a significant moderate positive correlation between changes of NT-proBNP levels and changes of LVIDd (r=0.459; P=0.006), as well as LVIDs (r=0.563; P=0.001). Conclusion In pediatric PDA and VSD patients, NT-proBNP levels have a significant positive correlation with diastolic and systolic left ventricle diameters at three months after closure. Decreased NT-proBNP levels may be considered as a marker of closure effectiveness.

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“…9 In addition, a study showed higher BNP levels in their ASD group (79 pg/mL) compared to a control group (57 pg/mL) (P<0.05). 10 This shows that BNP levels can match echocardiography in diagnosing the size of ASD.…”

Section: Discussionmentioning

confidence: 85%

Brain natriuretic peptide and atrial septal defect size in children

Lawang

Huntoyungo

Daud

2020

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Background Atrial septal defect (ASD) is one of the most common forms of congenital heart disease (CHD). Brain natriuretic peptide (BNP) is a heart marker released into the circulation during pressure overload, heart volume expansion, and increased stress on +the myocardial wall. Objective To assess for a possible association between atrial septal defect size and BNP level in pediatric patients. Methods This cross sectional study on children with ASD was done from March to December 2018 in pediatric outpatients and inpatients at Dr. Wahidin Sudirohusodo Hospital, Makassar, South Sulawesi. Measurement of ASD defect was conducted using echocardiography and categorized as small defect (<3 mm), medium defect (3-8 mm), and large defect (>8 mm). Brain natriuretic peptide was measured using radioimmunoassay and immunoradiometricassay. Nutritional status was categorized using WHO if the patients aged younger than 5 years and NCHS for patients aged equal or more than 5-year-old. Results Mean BNP levels were 65.5 pg/mL in the small ASD group, 273.2 pg/mL in the moderate ASD group, and in 654.5 pg/mL in the large ASD group, with significant differences among ASD groups. We found a significant positive correlation between BNP levels and ASD diameter (r=0.829; P=0.001), with Y regression equation of: (BNP level) =2.624 + 0.009X (ASD diameter in mm). Conclusion Brain natriuretic peptide levels have significant positive correlation with ASD size. Hence, BNP measurements can be used to predict septal defect size in children with ASD. Acyanotic CHD patients with suspected ASD and high BNP levels may have moderate-to-large ASDs.

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Serum Levels of Natriuretic Peptides in Children before and after Treatment for an Atrial Septal Defect, a Patent Ductus Arteriosus, and a Coarctation of the Aorta—A Prospective Study

Cited by 11 publications

References 48 publications

Neurohormonal activity and vascular properties late after aortic coarctation repair

Neurohormonal activity and vascular properties late after aortic coarctation repair

NT-proBNP level and left ventricle diameters before and after transcatheter closure of PDA and VSD

Brain natriuretic peptide and atrial septal defect size in children

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