Serum levels of nesfatin-1 and irisin in obese children

Dokumacıoğlu, Eda; İskender, Hatice; Şahin, Arzu; Ertürk, Emine Yurdakul; Kaynar, Özgür

doi:10.1684/ecn.2020.0444

Cited by 14 publications

(4 citation statements)

References 45 publications

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“…Several reports have shown that irisin expression is lower in obese individuals and in patients with T2D than in healthy subjects [119][120][121]. However, there are studies in which higher irisin levels have been noted in obese people than in non-obese individuals [55,122,123]. Several factors may contribute to these contradictory results: it is unknown whether irisin sensitivity decreases in the WAT or whether the irisin receptor becomes nonfunctional [124,125].…”

Section: Irisinmentioning

confidence: 99%

“…Also, the precise involvement of the concentration of nesfatin-1 in oxidative stress remains unclear [54]. The study of Dokumacioglu et al showed lower nesfatin-1 and superoxide dismutase (SOD) concentrations in obese children than in the control group [55]. On the contrary, the study of Gajewska et al found that nesfatin-1 levels positively correlated with the oxidative stress index in non-obese children with Prader-Willi syndrome, a result that may support the not fully elucidated role of nesfatin-1 in maintaining redox state [54].…”

Section: Nestatin-1mentioning

confidence: 99%

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The Role of Adipokines and Myokines in the Pathogenesis of Different Obesity Phenotypes—New Perspectives

Pelczyńska,

Miller-Kasprzak,

Piątkowski

et al. 2023

Antioxidants

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Obesity is a characteristic disease of the twenty-first century that is affecting an increasing percentage of society. Obesity expresses itself in different phenotypes: normal-weight obesity (NWO), metabolically obese normal-weight (MONW), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUO). A range of pathophysiological mechanisms underlie the occurrence of obesity, including inflammation, oxidative stress, adipokine secretion, and other processes related to the pathophysiology of adipose tissue (AT). Body mass index (BMI) is the key indicator in the diagnosis of obesity; however, in the case of the NWO and MONW phenotypes, the metabolic disturbances are present despite BMI being within the normal range. On the other hand, MHO subjects with elevated BMI values do not present metabolic abnormalities. The MUO phenotype involves both a high BMI value and an abnormal metabolic profile. In this regard, attention has been focused on the variety of molecules produced by AT and their role in the development of obesity. Nesfatin-1, neuregulin 4, myonectin, irisin, and brain-derived neurotrophic factor (BDNF) all seem to have protective effects against obesity. The primary mechanism underlying the action of nesfatin-1 involves an increase in insulin sensitivity and reduced food intake. Neuregulin 4 sup-presses lipogenesis, decreases lipid accumulation, and reduces chronic low-grade inflammation. Myonectin lowers the amount of fatty acids in the bloodstream by increasing their absorption in the liver and AT. Irisin stimulates the browning of white adipose tissue (WAT) and consequently in-creases energy expenditure, additionally regulating glucose metabolism. Another molecule, BDNF, has anorexigenic effects. Decorin protects against the development of hyperglycemia, but may also contribute to proinflammatory processes. Similar effects are shown in the case of visfatin and chemerin, which may predispose to obesity. Visfatin increases adipogenesis, causes cholesterol accumulation in macrophages, and contributes to the development of glucose intolerance. Chemerin induces angiogenesis, which promotes the expansion of AT. This review aims to discuss the role of adipokines and myokines in the pathogenesis of the different obesity phenotypes.

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Section: Irisinmentioning

confidence: 99%

Section: Nestatin-1mentioning

confidence: 99%

The Role of Adipokines and Myokines in the Pathogenesis of Different Obesity Phenotypes—New Perspectives

Pelczyńska,

Miller-Kasprzak,

Piątkowski

et al. 2023

Antioxidants

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“…Несмотря на различие медиан содержания НФ-1 при разной величине ИМТ у пациентов с РА, статистически значимая взаимосвязь не выявлена. Этот результат отличается от данных международной литературы, которые продемонстрировали взаимосвязь уровня НФ-1 с ожирением [13]. Следует отметить, что в указанных работах не исследовалась ассоциация концентрации НФ-1 и ИМТ у пациентов с системными воспалительными заболеваниями.…”

Section: результатыunclassified

Association of Nesfatin-1 Level with Body Composition in Patients with Rheumatoid Arthritis

Kvlividze,

Papichev,

Zavodovsky

et al. 2024

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Aim. To study the association of serum nesfatin 1 (NF-1) levels with body mass index (BMI), body composition and rheumatic cachexia (RC). Design. Cross-sectional comparative study. Materials and methods. 110 patients with rheumatoid arthritis (RA) and 60 healthy controls were enrolled in our study. Standard clinical and laboratory examination was performed. NF-1 levels were determined with enzyme-linked immunosorbent assay. Each person undergone dual-energy X-ray absorptiometry with Total Body program. Results. Serum NF-1 levels were higher in patients with RA, compared with healthy controls (50.49 ± 34.05 vs 31.61 ± 3.17 ng/ml, t = 4.28; p < 0.0001). RC was determined in 30 patients. In healthy controls, the median level of NF-1 was higher in overweight patients than with normal BMI of class 1 obesity (H = 6.0; p = 0.049). NF-1 in patients with RA correlated with lean mass in legs (separately for the left one), left half of the body, trunk and android region. Median levels of NF-1 in patients were comparable in patients with or without RC. Conclusion. Despite we observed association between serum NF-1 levels and lean tissue mass, this neuroendocrine peptide can’t be used as a marker for RC (Z = 1.45; p = 0.147). Additional studies should be performed to clarify the mechanism of association of NF-1 with lean tissue mass, which would likely contribute to the development of a new approach to controlling this indicator. Keywords: nesfatin 1, rheumatoid arthritis, body composition, body mass index, rheumatic cachexia.

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“…The relationship between irisin and obesity in children is still debated [10]. The association of irisin with anthropometric measurements and biochemical markers of obesity has been reported as positive in some studies [11][12][13][14][15], negative in some studies [16,17], and nonexistent or insignificant in others [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Association of Serum Irisin Levels with Body Composition, Metabolic Profile, Leptin, and Adiponectin Levels in Lean and Obese Children

Esin,

Batirel,

Ülfer

et al. 2023

Medicina

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Background and Objectives: Irisin is an adipo-myokine with potential metabolic effects in the body, and its association with childhood obesity is still controversial. This study aimed to investigate the relationship between serum irisin levels and anthropometric parameters, body composition, metabolic profiles, leptin, and adiponectin in obese and normal-weight children. Methods: The study sample consisted of a total of 80 children aged 6–10, including 44 obese children (BMI ≥ 97th percentile) and 36 normal-weight children. Anthropometric parameters were measured. Body composition was determined with the use of the Bioelectrical Impedance Analysis (BIA) method. Metabolic profiles, as well as irisin, leptin, and adiponectin levels, were analyzed. Results: Anthropometric parameters and body composition were found to be significantly different between the obese and normal-weight groups (p < 0.05). Fasting blood glucose, insulin, HOMA-IR, and leptin levels were found to be significantly higher in the obese group, while the normal-weight group had significantly higher HDL cholesterol and adiponectin levels (p < 0.05). Serum irisin levels did not differ between the obese and normal-weight groups, or based on sex, vitamin D levels, and insulin resistance status. There was also no statistically significant correlation between serum irisin levels and anthropometric parameters, metabolic profile, leptin, and adiponectin. Conclusions: The study concluded that the obese children who participated in this study had high leptin levels and low adiponectin levels, with no significant difference in the irisin levels between the groups. More comprehensive clinical studies are needed to investigate the relationship between irisin and adipokines in children.

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Serum levels of nesfatin-1 and irisin in obese children

Cited by 14 publications

References 45 publications

The Role of Adipokines and Myokines in the Pathogenesis of Different Obesity Phenotypes—New Perspectives

The Role of Adipokines and Myokines in the Pathogenesis of Different Obesity Phenotypes—New Perspectives

Association of Nesfatin-1 Level with Body Composition in Patients with Rheumatoid Arthritis

Association of Serum Irisin Levels with Body Composition, Metabolic Profile, Leptin, and Adiponectin Levels in Lean and Obese Children

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