Serum levels of novel adipokines, omentin-1 and chemerin, in patients with acute myocardial infarction

Kadoglou, Nikolaos P.E.; Tahmatzidis, Dimitrios; Giannakoulas, Christos; Kapelouzou, Alkistis; Gkontopoulos, Argirios; Parissis, John; Lampropoulos, Stylianos; Kottas, George

doi:10.2459/jcm.0000000000000053

Cited by 41 publications

(30 citation statements)

References 23 publications

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“…In another recent study (KOZANI), at baseline, the acute myocardial infarction group also had significantly lower omentin-1 values than healthy controls (P < 0.05) [15]. After 6 months of follow-up, the concentrations of omentin-1 levels in the KOZANI study considerably Table 5 Correlation between adipokine serum concentration and peripheral blood leucocyte mRNA expression.…”

Section: Discussionmentioning

confidence: 88%

Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls

et al. 2019

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Section: Discussionmentioning

confidence: 88%

Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls

et al. 2019

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“…The main function of chemerin was initially described as the regulator of glucolipid metabolic processes and inflammatory responses (Helfer and Wu, 2018). Recently, however, chemerin was reported to be a key regulator of cardiovascular disease, including hypertension, coronary atherosclerosis disease, and myocardial infarction (Kadoglou et al, 2015). In patients with type 2 diabetes, elevated serum levels of chemerin have been associated with heart failure (Zhou et al, 2019) while chemerin was shown to induce murine cardiomyocyte apoptosis through inflammatory processes (Rodriguez-Penas et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Chemerin/CMKLR1 Axis Promotes Inflammation and Pyroptosis by Activating NLRP3 Inflammasome in Diabetic Cardiomyopathy Rat

et al. 2020

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Chemerin and its receptor CMKLR1 (a G-protein-coupled receptor) are inducers of inflammation, and play an important role in diabetic cardiomyopathy (DCM). In this study, we investigated the role of the chemerin/CMKLR1 axis in mediating inflammation and cell death in DCM. Sprague-Dawley rats, treated with a high-fat diet and low-dose of streptozotocin, were used as a DCM model. CMKLR1 expression was knocked down by siRNA (CMKLR1-siRNA) to evaluate the role of CMKLR1 in DCM. Chemerintreated H9c2 cells were used to investigate the factors acting downstream of the chemerin/CMKLR1 axis. LDH release and EthD-III staining were used to measure the ratio of cell death in vitro. CMKLR1-siRNA and siRNA against nucleotide-binding oligomerization domain-like receptors 3 (NLRP3-siRNA) were used to explore the mechanism underlying chemerin-induced inflammation and cell death. The results showed that the expression of chemerin, CMKLR1, NLRP3, pro-caspase-1, activated caspase-1, and mature IL-1β was increased in the DCM model rat. Myocardium of DCM model rats exhibited fibrosis, hypertrophy, a disorganized ultrastructure, and impaired function. Pyroptosis was observed in vivo and in vitro. Silencing of CMKLR1 in vivo attenuated the expression of NLRP3 and activated caspase-1 and IL-1β. CMKLR1-siRNA treatment attenuated cardiac inflammation, fibrosis, hypertrophy, and pyroptosis, and improved cardiac function in vivo. Silencing of either CMKLR1 or NLRP3 suppressed the levels of activated caspase-1, IL-1β, and pyroptosis; however, silencing of both CMKLR1 and NLRP3 further decreased the levels of mature IL-1β and pyroptosis. Overall, the results showed that the chemerin/CMKLR1 axis contributed to the development of DCM and that the NLRP3 inflammasome mediated the chemerin/CMLR1-induced inflammation and pyroptosis. These data indicate that silencing of the CMKLR1 gene might exert a protective effect against DCM.

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“…Kadoglou et al (19) reported an in increase in chemerin levels in a study of patients with acute myocardial infarction (AMI). Ji et al (20) reported that plasma chemerin levels increased in patients with ACS, with the exception of stable angina pectoris.…”

Section: Groupmentioning

confidence: 99%

Diagnostic Value of Signal Peptide, CUB (Complement C1r/C1s, Uegf, and Bmp1), EGF (Epidermal Growth Factor)-Like Domain-Containing Protein 1 (SCUBE1) and Chemerin in Experimental Testicular Torsion

Yeniocak¹,

Saraç²,

Karadana³

et al. 2017

EAJEM

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Serum levels of novel adipokines, omentin-1 and chemerin, in patients with acute myocardial infarction

Abstract: Patients with AMI showed at admission lower omentin-1 and higher chemerin serum levels compared with healthy controls. The suppression of inflammation in the 6-month post-AMI period might have mediated the significant upregulation of omentin-1, implicating a novel target of treatment.

Cited by 41 publications

References 23 publications

Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls

Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls

Chemerin/CMKLR1 Axis Promotes Inflammation and Pyroptosis by Activating NLRP3 Inflammasome in Diabetic Cardiomyopathy Rat

Diagnostic Value of Signal Peptide, CUB (Complement C1r/C1s, Uegf, and Bmp1), EGF (Epidermal Growth Factor)-Like Domain-Containing Protein 1 (SCUBE1) and Chemerin in Experimental Testicular Torsion

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