Serum levels of pancreatic enzymes in lean and obese subjects

Kondo, Takaharu; Hayakawa, Tetsuo; Shibata, Tokimune; Sato, Yuzo; Toda, Y

doi:10.1007/bf02788453

Cited by 22 publications

(8 citation statements)

References 10 publications

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“…In this study, AMY level ranged from 1910 to 3,000 U L −1 with an average value of 2,563.45 U L −1 . The AMY level for most tigers was approximately 3,000 U L −1 , which could be interpreted as a sign of disease but was most likely related to a high-fat, high-protein or high-carbohydrate dietary (Grossman et al, 1943;Kondo et al, 1988). GLOB plays an important role in immunity, in addition to being related to the liver.…”

Section: Discussionmentioning

confidence: 99%

Haematological and Biochemical Parameters of Captive Siberian Tigers (Panthera tigris altaica) from the Heilongjiang Province, China

Liu

You

et al. 2020

Veterinary Medicine & Sci

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The Siberian tiger (Panthera tigris altaica) is one of the largest felines, and is mainly found in Russian Far East, northeast of China and north of Korea. Currently, there are approximately 400 wild Siberian tigers globally, with only a few of these in China (Peng et al., 2020).Therefore, they are listed as level I protected animals by the Chinese government, are included in the Convention on International Trade

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Section: Discussionmentioning

confidence: 99%

Haematological and Biochemical Parameters of Captive Siberian Tigers (Panthera tigris altaica) from the Heilongjiang Province, China

Liu

You

et al. 2020

Veterinary Medicine & Sci

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“…The different pattern of exocrine pancreas dysfunction observed between children and adults may explain why, in another study [ 18 ], pancreatic enzymes were not found reduced in individuals with low-risk of developing type 1 diabetes. However, it should be noted that a limitation of our study is the lack of body mass index (BMI) and pubertal status data, which may affect pancreatic enzyme levels [ 32 ]. Although serum P-amylase and lipase levels are not considered sensitive biomarkers of exocrine pancreas function [ 33 ], our data are consistent with previous reports showing that exocrine pancreatic enzymes are a serological biomarker for T1D staging.…”

Section: Discussionmentioning

confidence: 99%

Exocrine pancreas function is impaired in adult relatives of patients with type 1 diabetes

et al. 2021

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Aims Alterations of the exocrine pancreas have been reported in type 1 diabetes, but their contribution to the pathogenesis of the disease is poorly understood. Here, we investigated markers of exocrine pancreas dysfunction in individuals at-risk of developing type 1 diabetes. Methods Serum P-amylase and lipase levels were assessed in samples obtained from healthy controls, patients with new onset type 1 diabetes, relatives participating to the TrialNet Pathway to Prevention who were, at blood collection, autoantibody negative or positive for a single autoantibody (low-risk individuals), and positive for multiple autoantibodies (high-risk individuals). Linear mixed models were adopted to estimate variation of pancreatic enzymes among the groups and to evaluate the influence of high-risk HLA genotypes and residual beta cell function on exocrine pancreas function. Results In adults, but not children, reduced levels of P-amylase and lipase were shown in at-risk individuals, including (for P-amylase levels only) those at low-risk, and in T1Dnew. Furthermore, while high-risk HLA genotypes negatively affected P-amylase levels in autoantibody negative adult individuals, fasting C-peptide levels did not correlate with pancreatic enzyme levels. Conclusions Exocrine pancreas dysfunction precedes the onset of type 1 diabetes in adult at-risk individuals and may be unrelated to fasting C-peptide levels.

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“…82,83 Regarding serum amylase, several studies have examined fasting levels and observed lower amylase levels with increasing adiposity. [84][85][86][87] However, these results should be interpreted with caution as they could reflect changes in both pancreatic and salivary secretions. Interestingly, Bonnefond et al assessed the relationship between amylase (i.e., pancreatic and salivary) and adiposity by employing a systems biology approach combining genetic, protein, and metabolomic analyses.…”

Section: Pancreatic Amylasementioning

confidence: 92%

Understanding the gastrointestinal tract in obesity: From gut motility patterns to enzyme secretion

Steenackers,

Eksteen,

Wauters

et al. 2024

Neurogastroenterology Motil

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Background and PurposeThe pathophysiology of obesity has been the product of extensive research, revealing multiple interconnected mechanisms contributing to body weight regulation. The regulation of energy balance involves an intricate network, including the gut–neuroendocrine interplay. As a consequence, research on the gut–brain–microbiota axis in obesity has grown extensively. The physiology of the gastrointestinal tract, far from being underexplored, has significant implications for the development of specific complications in people living with obesity across the fields of gastroenterology, nutrition, and pharmacology. Clinical research indicates higher fasting bile acids serum levels, and blunted postprandial increases in bilious secretions in people living with obesity. Findings are less straightforward for the impact of obesity on gastric emptying with various studies reporting accelerated, normal, or delayed gastric emptying rates. Conversely, the effect of obesity on gastrointestinal pH, gastrointestinal transit, and gastric and pancreatic enzyme secretion is largely unknown. In this review, we explore the current evidence on the gastrointestinal physiology of obesity.

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Serum levels of pancreatic enzymes in lean and obese subjects

Cited by 22 publications

References 10 publications

Haematological and Biochemical Parameters of Captive Siberian Tigers (Panthera tigris altaica) from the Heilongjiang Province, China

Haematological and Biochemical Parameters of Captive Siberian Tigers (Panthera tigris altaica) from the Heilongjiang Province, China

Exocrine pancreas function is impaired in adult relatives of patients with type 1 diabetes

Understanding the gastrointestinal tract in obesity: From gut motility patterns to enzyme secretion

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