Serum levels of pentraxin-3 and other inflammatory biomarkers in migraine: Association with migraine characteristics

Ceylan, Mustafa; Bayraktutan, Omer Faruk; Becel, Sinan; Atis, Omer; Yalçın, Ahmet; Kotan, Dilcan

doi:10.1177/0333102415598757

Cited by 38 publications

(34 citation statements)

References 32 publications

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“…Additionally, it has been reported that the levels of acute phase protein increased in a variety of neurodegenerative diseases [36, 37]. For instance, Lee et al have observed high plasma PTX3 levels in idiopathic PD patients and found significant correlation between the PTX3 levels and daily life activities and motor functions [38].…”

Section: Discussionmentioning

confidence: 99%

Accumulation of α-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers

Solmaz

Ozlece

Eroğlu

et al. 2017

Neurology Research International

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Objective. The present study was conducted to evaluate the relationship between plasma oxidative stress markers such as malondialdehyde (MDA) and glutathione (GSH), inflammatory marker pentraxin-3 (PTX3), and cerebellar accumulation of α-synuclein in streptozotocin- (STZ-) induced diabetes model in rats. Methods. Twelve rats were included in the study. Diabetes (n = 6) was induced with a single intraperitoneal injection of streptozotocin (STZ, 60 mg/kg). Diabetes was verified after 48 h by measuring blood glucose levels. Six rats served as controls. Following 8 weeks, rats were sacrificed for biochemical and immunohistochemical evaluation. Results. Plasma MDA levels were significantly higher in diabetic rats when compared with the control rats (p < 0.01), while plasma GSH levels were lower in the diabetic group than in the control group (p < 0.01). Also, plasma pentraxin-3 levels were statistically higher in diabetic rats than in the control rats (p < 0.01). The analysis of cerebellar α-synuclein immunohistochemistry showed a significant increase in α-synuclein immunoexpression in the diabetic group compared to the control group (p < 0.01). Conclusion. Due to increased inflammation and oxidative stress in the chronic period of hyperglycemia linked to diabetes, there may be α-synuclein accumulation in the cerebellum and the plasma PTX3 levels may be assessed as an important biomarker of this situation.

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Section: Discussionmentioning

confidence: 99%

Accumulation of α-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers

Solmaz

Ozlece

Eroğlu

et al. 2017

Neurology Research International

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“…Pentraxin 3 (PTX3) is a member of the long pentraxin family that acts as an acute phase inflammatory glycoprotein [10]. Two studies have demonstrated higher plasma levels of PTX3 in migraine patients during attacks when compared to interictal periods [11] or healthy controls [12]. Plasma levels of soluble tumour necrosis factor-like weak inducer of apoptosis (sTWEAK) have been analysed as potential biomarkers of cardiovascular disease and endothelial dysfunction in vascular [13][14][15] and non-vascular diseases [16].…”

Section: Introductionmentioning

confidence: 99%

Pentraxin 3 (PTX3): A Molecular Marker of Endothelial Dysfunction in Chronic Migraine

Domínguez-Vivero

Leira

López-Ferreiro

et al. 2020

JCM

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Even though endothelial dysfunction is known to play a role in migraine pathophysiology, studies regarding levels of endothelial biomarkers in migraine have controversial results. Our aim was to evaluate the role of pentraxin 3 (PTX3) and soluble tumour necrosis factor-like weak inducer of apoptosis (sTWEAK) as potential biomarkers of endothelial dysfunction in chronic migraine (CM). We performed a case-control study including 102 CM patients and 28 control subjects and measured serum levels of markers of endothelial dysfunction (PTX3 and sTWEAK) and inflammation [high-sensitivity C-reactive protein (hs-CRP)] as well as brachial artery flow-mediated dilation (FMD) during interictal periods. Interictal serum levels of PTX3 and sTWEAK were higher in CM patients than in controls (1350.6 ± 54.8 versus 476.1 ± 49.4 pg/mL, p < 0.001 and 255.7 ± 21.1 versus 26.4 ± 2.6 pg/mL, p < 0.0001; respectively). FMD was diminished in CM patients compared to controls (9.6 ± 0.6 versus 15.2 ± 0.9%, p < 0.001). Both PTX3 and sTWEAK were negatively correlated with FMD (r = −0.508, p < 0.001 and r = −0.188, p = 0.033; respectively). After adjustment of confounders, PTX3 remained significantly correlated to FMD (r = −0.250, p = 0.013). Diagnosis of CM was 68.4 times more likely in an individual with levels of PTX3 ≥ 832.5 pg/mL, suggesting that PTX3 could be a novel biomarker of endothelial dysfunction in CM.

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“…A critical study by Ceylan et al investigating inflammatory markers in serum in migraine patients found higher levels of fibrinogen and pentraxin-3 (PTX-3) in migraine patients suffering acute attacks as compared to those in healthy control patients. However, the same study found no significant difference in C-reactive protein (CRP) levels between the patient groups within the attack and interictal period [24]. Remarkably, they found higher serum levels of fibrinogen and PTX-3 in migraine attack patients compared with patients during the interictal period [24].…”

Section: The Results Of the Comparisons Of Nlr Between The Patient Grmentioning

confidence: 88%

“…However, the same study found no significant difference in C-reactive protein (CRP) levels between the patient groups within the attack and interictal period [24]. Remarkably, they found higher serum levels of fibrinogen and PTX-3 in migraine attack patients compared with patients during the interictal period [24]. Among the inflammatory markers used in the clinical practice, WBC count is a crucial one used also widely in scientific researches.…”

Section: The Results Of the Comparisons Of Nlr Between The Patient Grmentioning

confidence: 93%

“…Many researchers have investigated the relationships between the features of headaches and inflammation using hematologic parameters [3,6,10,13,[21][22][23]. The main goal of these studies is to evaluate the inflammatory processes using hematological markers and to investigate the association of these markers with clinical parameters of headaches, and their utility in discriminating headache syndromes from other diseases [10,24]. A critical study by Ceylan et al investigating inflammatory markers in serum in migraine patients found higher levels of fibrinogen and pentraxin-3 (PTX-3) in migraine patients suffering acute attacks as compared to those in healthy control patients.…”

Section: The Results Of the Comparisons Of Nlr Between The Patient Grmentioning

confidence: 99%

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May Neutrophil to Lymphocyte Ratio Serve a Role in the Prediction of Clinical Features of Migraine?

Önder

Deliktas

2020

J Neurol Res

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Background: We aimed to investigate the possible association between the value of neutrophil to lymphocyte ratio (NLR) and some specific features of migraine. Methods:We have included initially all the patients with migraine who applied to our neurology clinic in Yozgat City Hospital during December 2019 and agreed to participate in this study. The demographic and clinical characteristics including migraine subtype (episodic/chronic), headache frequency per month, headache characteristics of all patients were interrogated. Besides, the presence of fibromyalgia (FM) and chronic fatigue syndrome (CFS) was also noted. The severity of migraine was assessed using the headache impact test (HIT-6) and the severity of chronic fatigue was assessed using the Functional Assessment of Chronic Illness Therapy (FACIT) fatigue scale. A hemogram was performed upon admission to the clinic. The patients with migraine attacks during the clinic visits were excluded from the study.Results: Ultimately, 52 migraineurs were included in this study. The mean age was 37.34 ± 11.80 and the female/male (F/M) ratio was 49/3. Thirty-six patients (69%) were diagnosed with episodic migraine (EM), and 16 of them (31%) were diagnosed with chronic migraine (CM). The results of the comparative analyses between EM and CM groups showed that the NLR did not differ between groups. To evaluate the possible association of the NLR with other clinical parameters, additional comparative analyses evaluating the presence of FM, CFS, cognitive symptoms and tinnitus were also conducted, which showed no significant differences. The results of the correlation analyses to evaluate the possible associations between the NLR value and other clinical parameters were also unremarkable. Conclusions:We suggest that the NLR cannot be a specific marker to be used in the differential diagnosis or prediction of any features of migraines during the interictal period. However, in light of the previous reports, the utility of this value in the differentiating of migraine attacks from other causes of headache attacks can be investigated in future related studies.

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Serum levels of pentraxin-3 and other inflammatory biomarkers in migraine: Association with migraine characteristics

Cited by 38 publications

References 32 publications

Accumulation of α-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers

Accumulation of α-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers

Pentraxin 3 (PTX3): A Molecular Marker of Endothelial Dysfunction in Chronic Migraine

May Neutrophil to Lymphocyte Ratio Serve a Role in the Prediction of Clinical Features of Migraine?

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