Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples

Monroy, R.; Morrison, Katherine M.; Teo, Koon K.; Atkinson, Stephanie A.; Kubwabo, Cariton; Stewart, Brent K.; Foster, Warren G.

doi:10.1016/j.envres.2008.06.001

Cited by 281 publications

(205 citation statements)

References 26 publications

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“…In the present study, we found higher levels of PFCs in maternal serum than in cord serum, which is consistent with previous studies (Monroy et al 2008;Hanssen et al 2010;Beesoon et al 2011). Maternal and cord PFOS and PFOA concentrations were among the highest in Europe (Midasch et al 2007;Fei et al 2007;Needham et al 2011) and even among the highest in the world (Liu et al 2011;Kim et al 2011a, b;Beesoon et al 2011).…”

Section: Discussionsupporting

confidence: 82%

Determinants of maternal and fetal exposure and temporal trends of perfluorinated compounds

Ode

Rylander

Lindh

et al. 2013

Environ Sci Pollut Res

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Section: Discussionsupporting

confidence: 82%

Determinants of maternal and fetal exposure and temporal trends of perfluorinated compounds

Ode

Rylander

Lindh

et al. 2013

Environ Sci Pollut Res

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“…Most of the earlier studies 17,20,23,26) , but not others 18,24) , showed significantly lower serum levels of PFOA in women than in men. The reason for the lack of sex difference in PFOA levels observed in our study may be in part because lower blood levels at reproductive ages (16−39 years) were canceled out by the higher blood levels at postmenopausal ages (≥60 years) in women; it has been reported that blood levels of PFOA also decrease during pregnancy 27) and increase after menopause 28) . PFOS levels in blood increased with advancing age in both men and women, whereas PFOA levels increased with age only in women.…”

Section: Discussionmentioning

confidence: 47%

“…In our analysis in women, PFOS levels in blood were lower among those with an experience of pregnancy. One report showed that maternal serum levels of PFOS decreased significantly from 24−28 weeks of gestation to the time of delivery 27) . Menstruation has been suggested as another route of excretion of PFOS 28) .…”

Section: Discussionmentioning

confidence: 99%

Consumption of Seafood, Serum Liver Enzymes, and Blood Levels of PFOS and PFOA in the Japanese Population

Yamaguchi

Arisawa

Uemura

et al. 2013

Journal of Occupational Health

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PFOA, with medians being highest in the Tokai/Hokuriku/ Kinki region. Conclusions: These findings suggest that the concentrations of PFOS in blood were mainly associated with fish consumption and that the levels of PFOS and PFOA were associated with the serum levels of liver enzymes in Japanese populations. Further investigations are required to clarify the reason for the regional differences in blood levels of PFOS and PFOA in Japan. (J Occup Health 2013; 55: 184−194) Key words: Blood, Fish intake, Perfluorooctanesulfonate (PFOS), Perfluorooctanoate (PFOA), Serum liver enzymes Perfluorochemicals (PFCs) are man-made chemical substances containing C-C and C-F bonds. PFCs are extremely resistant to degradation, and accumulate in the environment. Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are two of the main PFCs. PFOS and PFOA have both hydrophilic and lipophilic properties. PFOS bioaccumulates in animal tissues through the food web 1) , and exposure to PFOA occurs in part through drinking water and beverages 2) . The geometric mean elimination half-lives of PFOS and PFOA from human serum are approximately 4.8 and 3.5 years, respectively 3) . Recently, it has been reported that PFOS and PFOA have toxic effects on wildlife and humans. The toxicity includes neurobehavioral defects 4) , hepatotoxicity 5) , immune toxicity and carcinogenicity 6) . A reduction in human exposure to PFCs has been reported following the phasing-out of perfluorosulfonyl-based compounds and the Environmental Protection Agency's program The purpose of the present study was to examine the factors associated with the blood levels of PFOS and PFOA. Methods: A cross-sectional study was performed on 307 men and 301 women (aged 16−76 years) living in 15 prefectures in Japan. Blood levels of PFOS and PFOA were measured by liquid chromatography-mass spectrometry. Hepatic enzymes (γ -GTP, GOT, and GPT) and ω -3 polyunsaturated fatty acids (DHA and EPA) levels in serum were also measured. Associations between the levels of PFOS and PFOA in blood and the intake frequency of 41 kinds of dishes, foods and beverages and the serum levels of liver enzymes and ω -3 polyunsaturated fatty acids were examined using rank correlations. Results: Frequency of intake of boiled fish in broth, sliced raw fish and coastal fish showed significant positive correlations with PFOS concentrations in blood after adjustments for potential confounders. Serum levels of GOT, GPT, DHA and EPA showed significant positive correlations with PFOS and PFOA in blood. There was also a significant regional difference in the blood levels of PFOS and

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“…19) In addition, PFOA can cross the placenta and enter the fetal circulation. 20) Hines et al 10) reported that in utero exposure of PFOA at 0.01 mg/kg BW for 17 days increases BW gain in mice at following period, but there is no effect on adult mice exposed to PFOA at 3 mg/kg BW for 17 days at any endpoint. Therefore, these findings suggest that the susceptibility to PFOA during the developmental period is greater than that in adults.…”

mentioning

confidence: 99%

Perfluorooctanoic acid binds to peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation in 3T3-L1 adipocytes

Yamamoto

Yamane

Oishi

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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We examined the effect of perfluorooctanoic acid (PFOA) on adipose cells using 3T3-L1 adipocytes and found that PFOA increased adipocyte differentiation, triglyceride accumulation, and the mRNA level of factors related to adipocyte differentiation. In addition, PFOA bound to peroxisome proliferator-activated receptor γ (PPAR γ). These results suggest that PFOA promotes adipocyte differentiation as a PPAR γ ligand.

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Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples

Cited by 281 publications

References 26 publications

Determinants of maternal and fetal exposure and temporal trends of perfluorinated compounds

Determinants of maternal and fetal exposure and temporal trends of perfluorinated compounds

Consumption of Seafood, Serum Liver Enzymes, and Blood Levels of PFOS and PFOA in the Japanese Population

Perfluorooctanoic acid binds to peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation in 3T3-L1 adipocytes

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