Serum Levels of Pregnancy-Specific β₁-Glycoprotein (SP₁) in Women with Pregnancies at Risk

Abstract

Pregnancy-specific Β₁-glycoprotein (SP₁) concentrations were measured by nephelometry in 133 serum samples from 74 women in their last trimester of pregnancy. All women carried one child but their pregnancies were complicated by pre-eclampsia, essential hypertension, diabetes mellitus or rhesus isoimmunization. Most of the women with pre-eclampsia or essential hypertension who gave birth to infants of normal weight had SP₁ values evenly distributed within the reference range. Women with insulin-dependent diabetes mellitus who gave birth to infants of normal birth weight or large-for-date infants had SP₁ levels well within the reference range and even showed a tendency to overrepresentation above the geometric mean. Women with rhesus isoimmunization all delivered infants of normal birth weight. Their SP₁ values were near or above the geometric mean of the reference range. No special pattern of SP₁ levels was observed in relation to the severity of the immunization.

Serum markers for pre-eclampsia: An update on the analytes to be determined in the first, second, and third trimester

“…We have determined SP1 and HPL in our project [33]. For SP1 no difference was found, confirming an early study [45]. For HPL, however, we have observed a significant decrease for the case group in our study [33], and this is not in full agreement with an early study where this marker was increased in primigravid pre-eclampsia patients, but not in multigravid pregnancies suffering from the same disease [46].…”

Gestational diabetic transcriptomic profiling of microdissected human trophoblast

“…The expression of pregnancy-specific 1 glycoprotein (PSG), a common placental factor produced by trophoblast to allow for a viable pregnancy, has been reported to increase in preeclampsia (also known to be associated with increased insulin resistance (Catalano et al 2012) and GDM (Okazaki et al 2007, Tamsen et al 1983). Increased PSG levels are associated with elevated carbohydrate levels in humans with GDM (Neufeld et al 1984).…”