Serum levels of proinflammatory cytokines are high in early childhood caries

Lima, Gisele Quariguasi Tobias; Brondani, Mario; Silva, Antônio Augusto Moura da; Carmo, Cadidja Dayanne Sousa; Silva, Rubenice Amaral da; Ribeiro, Cecília Cláudia Costa

doi:10.1016/j.cyto.2018.05.031

Cited by 11 publications

(9 citation statements)

References 33 publications

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“…ECC leads to pain when not managed, and the pain contributes to poor feeding, nutrient deficiency [2–4] and growth failure (underweight, stunted and wasted) [5, 6]. Also, children with ECC have high levels of pro-inflammatory cytokines [7], which trigger a cascade of inflammatory processes [8] associated with impaired growth and obesity inducing mechanisms [9]. Obesity and stunting also cause changes in the salivary glands and the composition of saliva, which increases the risk for ECC by lowering salivary pH [10].…”

Section: Introductionmentioning

confidence: 99%

Association between early childhood caries and malnutrition in a sub-urban population in Nigeria

et al. 2019

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BackgroundTo determine the association between malnutrition and early childhood caries (ECC) in children resident in sub-urban, Nigeria.MethodsThis study was a subset of a larger cross-sectional study the data of which was generated through a household survey conducted in Ile-Ife, Nigeria. The study’s explanatory variable was malnutrition (underweight, overweight, wasting and stunting) and the outcome variable was ECC. Poisson regression analysis was used to determine the association between ECC and malnutrition. Variables (sex, frequency of sugar consumption, maternal knowledge of oral hygiene, oral hygiene status) associated with ECC in the primary study were adjusted for to obtain the adjusted prevalence ratio (APR).ResultsOf the 370 children, 20 (5.41%) were underweight, 20 (5.41%) were overweight, 67 (18.11%) were wasting, 120 (32.43%) were stunted and 18 (4.86%) had ECC. Factors associated with ECC were being stunted, underweight, overweight and fair oral hygiene. The prevalence of ECC was lower in children who were stunted (APR: 0.14; 95% CI: 0.03–0.69; p = 0.02), almost seven times higher in children who were overweight (APR: 6.88; 95% CI: 1.83–25.85; p < 0.001), and predictively absent in children who were underweight (APR: 0; 95% CI: 0–0; p < 0.001) when compared with children who had normal weight. Non-significant risk indicators for ECC included consuming sugar between meals three times a day or more, having low socioeconomic status and being female.ConclusionsFor this study population, the indicators of malnutrition – being stunted, underweight, overweight - and fair oral hygiene were risk indicators for ECC. The frequency of sugar consumption was not a significant risk indicator when malnutrition was included as an explanatory variable for ECC in the study population.

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Section: Introductionmentioning

confidence: 99%

Association between early childhood caries and malnutrition in a sub-urban population in Nigeria

et al. 2019

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“…ECC leads to pain when not managed, and the pain contributes to poor feeding, nutrient deficiency [2][3][4] and growth failure (underweight, stunted and wasted) [5,6]. Also, children with ECC have high levels of proinflammatory cytokines [7], which trigger a cascade of inflammatory processes [8] associated with impaired growth and obesity inducing mechanisms [9]. Obesity and stunting also cause changes in the salivary glands and the composition of saliva, which increases the risk for ECC by lowering salivary pH [10].…”

Section: Introductionmentioning

confidence: 99%

Association Between Early Childhood Caries And Malnutrition In A Sub-Urban Population In Nigeria

Foláyan¹,

Arije

Tantawi

et al. 2019

Preprint

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Background : To determine the association between malnutrition and early childhood caries (ECC) in children resident in sub-urban, Nigeria. Methods : This study is a secondary analysis of a larger cross-sectional data generated through a household survey. Variables (sex, frequency of sugar consumption, maternal knowledge of oral hygiene, oral hygiene status) associated with ECC in the primary study conducted in the Ile-Ife, Nigeria, were adjusted for in the models. We used Poisson regression analysis to determine the association between ECC and malnutrition (stunting, overweight and underweight). We reported the adjusted prevalence ratio (APR). Results: Of the 370 children, 20 (5.41%) were underweight, 20 (5.41%) were overweight, 67 (18.11%) were wasting, 120 (32.43%) were stunted and 18 (4.86%) had ECC. Factors associated with ECC were being stunted, underweight, overweight and fair oral hygiene. The prevalence of ECC was lower in children who were stunted (APR: 0.14; 95% CI: 0.03-0.69; p=0.02), almost seven times higher in children who were overweight (APR: 6.88; 95% CI: 1.83-25.85; p<0.001), and predictively absent in children who were underweight (APR: 0; 95% CI: 0-0; p<0.001) when compared with children who had normal weight. Non-significant risk indicators for ECC included consuming sugar between meals three times a day or more, having low socioeconomic status and being female. Conclusions : For this study population, the indicators of malnutrition – being stunted, underweight, overweight - and fair oral hygiene were risk indicators for ECC, while the frequency of sugar consumption was not a significant risk indicator. Further studies are needed to identify if there are other mediators of associations between ECC and nutrition status apart from sugar consumption.

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“…The inflammatory response around the dental pulp tissue often takes place after dental caries or traumas and is characterized by the accumulation of inflammatory cells (Lima et al, 2018; M. Wang et al, 2017). Inflammatory cells release various inflammatory cytokines, including tumor necrosis factor‐α (TNF‐α).…”

Section: Introductionmentioning

confidence: 99%

RICK regulates the odontogenic differentiation of dental pulp stem cells through activation of TNF‐α via the ERK and not through NF‐κB signaling pathway

Zhang

Lian

Zhao

et al. 2021

Cell Biology International

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Dental pulp stem cells (DPSCs) are capable of both self‐renewal and multilineage differentiation, which play a positive role in dentinogenesis. Studies have shown that tumor necrosis factor‐α (TNF‐α) is involved in the differentiation of DPSCs under pro‐inflammatory stimuli, but the mechanism of action of TNF‐α is unknown. Rip‐like interacting caspase‐like apoptosis‐regulatory protein kinase (RICK) is a biomarker of an early inflammatory response that plays a key role in modulating cell differentiation, but the role of RICK in DPSCs is still unclear. In this study, we identified that RICK regulates TNF‐α‐mediated odontogenic differentiation of DPSCs via the ERK signaling pathway. The expression of the biomarkers of odontogenic differentiation dental matrix protein‐1 (DMP‐1), dentin sialophosphoprotein (DSPP), biomarkers of odontogenic differentiation, increased in low concentration (1–10 ng/ml) of TNF‐α and decreased in high concentration (50–100 ng/ml). Odontogenic differentiation increased over time in the odontogenic differentiation medium. In the presence of 10 ng/L TNF‐α, the expression of RICK increased gradually over time, along with odontogenic differentiation. Genetic silencing of RICK expression reduced the expression of odontogenic markers DMP‐1 and DSPP. The ERK, but not the NF‐κB signaling pathway, was activated during the odontogenic differentiation of DPSCs. ERK signaling modulators decreased when RICK expression was inhibited. PD98059, an ERK inhibitor, blocked the odontogenic differentiation of DPSCs induced by TNF‐α. These results provide a further theoretical and experimental basis for the potential use of RICK in targeted therapy for dentin regeneration.

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Serum levels of proinflammatory cytokines are high in early childhood caries

Cited by 11 publications

References 33 publications

Association between early childhood caries and malnutrition in a sub-urban population in Nigeria

Association between early childhood caries and malnutrition in a sub-urban population in Nigeria

Association Between Early Childhood Caries And Malnutrition In A Sub-Urban Population In Nigeria

RICK regulates the odontogenic differentiation of dental pulp stem cells through activation of TNF‐α via the ERK and not through NF‐κB signaling pathway

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