Serum levels of renin, angiotensin-converting enzyme and angiotensin II in patients treated by surgical excision, propranolol and captopril for problematic proliferating infantile haemangioma

Sulzberger, L.; Baillie, Ranui; Itinteang, Tinte; Jong, Sophie de; Marsh, Reginald; Leadbitter, Phillip; Tan, Swee T.

doi:10.1016/j.bjps.2015.10.020

Cited by 14 publications

(18 citation statements)

References 26 publications

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“… 18 The antihypertensive therapy could reverse these changes. 19 In this sense, it has been seen that ACEI as captopril or a new thiomorpholine compound decreases ACE messenger RNA and reactivity of Ang-II in SHR to levels obtained in normotensive rat; 20 propranolol treatment reduces the renin 21 and ACE levels in infantile hemangioma; 22 losartan, an ARA, attenuates cardiac oxidative stress induced by Ang-II. 23 According to these evidence, our data obtained corroborated the results mentioned above, due to the fact that captopril, losartan, and propranolol reduced the BP values ( Table 1 ) and Ang-II induced reactivity only with the 2 first while propranolol increased it ( Figures 1 and 2 ).…”

Section: Discussionmentioning

confidence: 99%

Combination of β Adrenergic Receptor Block and Renin–Angiotensin System Inhibition Diminished the Angiotensin II-Induced Vasoconstriction and Increased Bradykinin-Induced Vasodilation in Hypertension

et al. 2017

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In hypertension, the combination therapy is frequently used to obtain a better therapeutic effect and reduce adverse effects. One effective combination is with inhibitors and β-blockers of renin–angiotensin system. Although the mechanisms of action of each drug are already known, the antihypertensive mechanism is more complex and therefore the combined treatment mechanism is unclear. Specifically, the effect of the treatments of angiotensin-converting enzyme inhibitor or AT1 receptor antagonist with β-blocker on the angiotensin II and bradykinin reactivity has not been studied. For this reason, we evaluated the interaction between propranolol and captopril or losartan on vascular reactivity to bradykinin and angiotensin II in spontaneously hypertensive rat. We constructed concentration–response curves to angiotensin II and bradykinin after treatment of SHR with propranolol–captopril or propranolol–losartan by using rat aortic rings. While losartan or captopril with propranolol potentiated bradykinin-induced vasodilation effect, the propranolol–losartan interaction decreased the angiotensin II-induced vasoconstriction. In addition, the combinations did not reduce the heart rate significantly. These results suggest that the combined therapy decreased blood pressure to normotensive values and showed less effect for angiotensin II and greater effect for bradykinin than monotherapy which could contribute in the antihypertensive effect.

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Section: Discussionmentioning

confidence: 99%

Combination of β Adrenergic Receptor Block and Renin–Angiotensin System Inhibition Diminished the Angiotensin II-Induced Vasoconstriction and Increased Bradykinin-Induced Vasodilation in Hypertension

et al. 2017

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“…proliferation (15). Results from the same laboratory showed that excision of the tumor can reduce the levels of renin and AGTII in vivo (16). These findings support the notion that AGTII not only induces tissue growth but also modulates its own availability through the upregulation of RAA axis components.…”

Section: Discussionmentioning

confidence: 59%

“…Angiogenic factors, such as vascular endothelial growth factor, endothelial nitric oxide synthase, and hypoxia-inducible factor, have been implicated in both the natural history and treatment of IH (2-4,8,9. ) In addition, the renin-angiotensin-aldosterone (RAA) pathway has been shown to be involved in the regulation of many of the angiogenic factors and processes implicated in IH development (10)(11)(12)(13)(14)(15)(16)(17).…”

mentioning

confidence: 99%

“…Recent reports on the role of the RAA axis in the physiology of IH have shown angiotensin II (AGTII), a major product in the RAA axis, to be involved in both IH and mesenchymal cell lines (10)(11)(12)(13)(14)(15)(16)(17). Specifically, AGTII can induce vascular cell growth in culture, and its action can be blocked at the level of its receptor or with ACE (15).…”

mentioning

confidence: 99%

“…Specifically, AGTII can induce vascular cell growth in culture, and its action can be blocked at the level of its receptor or with ACE (15). In addition, RAA axis components have been shown to be present in IH tissue, and excision of IH tissue has been shown to lower serum levels of these factors in vivo (16,17). Propranolol activity in the treatment of IH has been well documented (2,3,5-7).…”

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confidence: 99%

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The expression of renin–angiotensin–aldosterone axis components in infantile hemangioma tissue and the impact of propranolol treatment

et al. 2017

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BackgroundPropranolol's mechanism of action for controlling infantile hemangioma (IH) remains unclear. We hypothesize that this nonselective beta antagonist downregulates renin-angiotensin-aldosterone (RAA) axis components, preventing angiogenic substrate induction of IH.MethodsIH tissue and serum were collected from children with propranolol-treated or -untreated IH during surgery. Normal skin and serum from demographically matched children were used as controls. Real-time PCR and western blot quantified RAA components in proliferative (n=10), involuting (n=10), propranolol-treated (n=12) IH, and normal specimens (n=11). Serum was analyzed by enzyme-linked immunosorbent assay (ELISA).ResultsThere were significantly greater messenger RNA (mRNA) levels of angiotensinogen (AGT) in proliferating IH, but not in involuting or treated IH, when compared with controls (P<0.05). Angiotensin-converting enzyme (ACE) and angiotensin II receptor 1 (AGTR1) mRNA expression was higher in all IH specimens when comparedwith controls (P<0.05). ACE and AGTR1 protein expression was greater in proliferating IH tissue compared with that in controls and in involuting and treated IH tissue (P<0.05). ELISA showed no significant difference in ACE serum levels but did show a significant reduction in renin in involuting compared with proliferating IH (P<0.05).ConclusionsThe protein and mRNA expression of several RAA pathway constituents is elevated in IH tissue when compared with that in normal tissue. The action of propranolol on IH may be the result of reductions in ACE and AGTR1.

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The Renin-Angiotensin System and Cancer

Koh

Kilmister

Wickremesekera

et al. 2023

Advances in Biochemistry in Health and Disease

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Serum levels of renin, angiotensin-converting enzyme and angiotensin II in patients treated by surgical excision, propranolol and captopril for problematic proliferating infantile haemangioma

Cited by 14 publications

References 26 publications

Combination of β Adrenergic Receptor Block and Renin–Angiotensin System Inhibition Diminished the Angiotensin II-Induced Vasoconstriction and Increased Bradykinin-Induced Vasodilation in Hypertension

Combination of β Adrenergic Receptor Block and Renin–Angiotensin System Inhibition Diminished the Angiotensin II-Induced Vasoconstriction and Increased Bradykinin-Induced Vasodilation in Hypertension

The expression of renin–angiotensin–aldosterone axis components in infantile hemangioma tissue and the impact of propranolol treatment

The Renin-Angiotensin System and Cancer

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