Serum levels of sTNF-R1, sTNF-R2 and CXCL9 correlate with disease activity in adult type paracoccidioidomycosis

Lyon, Ana Cláudia; Teixeira, Mauro Martins; Araújo, Stanley Almeida; Pereira, Marta Máximo; Pedroso, Ênio Roberto Pietra; Teixeira, Antônio Lúcio

doi:10.1016/j.actatropica.2008.11.010

Cited by 13 publications

(14 citation statements)

References 34 publications

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“…Chronic pulmonary insufficiency caused by fibrosis is the most severe sequela of the disease 9,22,23,25 . In general, just two classifications are used: acute or juvenile paracoccidioidomycosis and chronic or adult paracoccidioidomycosis, each one with different levels of cellular immunodeficiency 3,26 …”

Section: Clinical Featuresmentioning

confidence: 99%

“…Paracoccidioidomycosis, also known as Lutz disease or Lutz‐Splendore‐Almeida mycosis, is a deep systemic disease, considered the principal endemic mycosis in Latin America 1–4 . It was first described by Adolpho Lutz in 1908 who examined a patient with oral lesions and cervical lymphadenopathy, from which the fungus was isolated.…”

Section: Introductionmentioning

confidence: 99%

“…Paracoccidioidomycosis, also known as Lutz disease or Lutz-Splendore-Almeida mycosis, is a deep systemic disease, considered the principal endemic mycosis in Latin America. [1][2][3][4] It was first described by Adolpho Lutz in 1908 who examined a patient with oral lesions and cervical lymphadenopathy, from which the fungus was isolated. The morphological and biological characterisation of the pathogen was made by Alfonso Splendore in 1912, who called it Zymonema brasiliensis, and by Floriano Paulo Almeida, who proposed the name Paracoccidioides brasiliensis in 1930.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Important aspects of oral paracoccidioidomycosis–a literature review

Silva

Salum

Figueiredo

et al. 2012

Mycoses

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Paracoccidioidomycosis is a deep mycosis endemic to Latin America, with considerable morbidity and mortality. It is caused by the dimorphic fungus Paracoccidioides brasiliensis, which affects, among other organs in the human body, the oral cavity. Fungus virulence and immunocompetence of the host determine the establishment of infection or active disease, whose severity and clinical behaviour depend mostly on the cellular immune response of the host. Often, oral lesions constitute the first sign and site of confirmation of diagnosis, which in most cases is delayed. The success of the treatment depends on early and correct diagnosis, as well as on the patient's adherence to the drug therapy.

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Section: Clinical Featuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Important aspects of oral paracoccidioidomycosis–a literature review

Silva

Salum

Figueiredo

et al. 2012

Mycoses

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“…39,57 Elevated levels of IL-18 and sTNF -RII in patients with the acute form are associated with severity, 58 and sTNF-R1, sTNF-R2 and the chemokine CXCL9 in the chronic form indicate active disease. 59 In a recent study, Siqueira et al 2009 showed that addition of IL-6 to monocyte culture allowed the proliferation of P. brasiliensis when these cells were challenged with a virulent strain of the fungus. The mechanisms by which monocytes allow the proliferation of the fungus in the presence of IL-6 are not known; however, the elucidation of this process might contribute to the understanding of the role of this cytokine in the pathogenesis of PCM.…”

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confidence: 99%

Imunologia da paracoccidioidomicose

Fortes¹,

Miot

Kurokawa³

et al. 2011

An. Bras. Dermatol.

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Paracoccidioidomycosis is the most prevalent systemic mycosis in Latin America, among immunecompetent patients. It's caused by the dimorphic fungus Paracoccidioiddes brasiliensis. Investigations regarding its immunopathogenesis are very important in the understanding of aspects related to natural history, as the protective immunity, and the relationship between host and parasite; also favoring the knowledge about clinical patterns and the elaboration of therapeutic strategies. The disease clinical polymorphism depends, at least, of the immune response profile according to the tissue and blood released citokynes, resulting in tissue damage. Keywords: Allergy and immunology; Cytokines; Paracoccidioides; Paracoccidioidomycosis Resumo: Paracoccidioidomicose é a mais prevalente micose sistêmica na América Latina, em pacientes imunocompetentes, sendo causada pelo fungo dimórfico Paracoccidioiddes brasiliensis. O estudo da sua imunopatogênese é importante na compreensão de aspectos relacionados à história natural, como a imunidade protetora, e à relação entre hospedeiro e parasita, favorecendo o entendimento clínico e a elaboração de estratégias terapêuticas. O polimorfismo clínico da doença depende, em última análise, do perfil de resposta imune que prevalece expresso pelo padrão de citocinas teciduais e circulantes, além da qualidade da resposta imune desencadeada, que levam ao dano tecidual.

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“…The molecules referred to above could be considered as markers when discriminating PCM cases from controls and could also be useful when treatment follow-up is considered. Indeed, in a study with human PCM patients, serum levels of MIG/CXCL9 were higher in all untreated cases and decreased progressively with treatment [32]. In addition, MIG, RANTES and IL12p40 appeared to be of help in maintaining cellular recruitment during the chronic periods of the Pb -infection when the remaining chemokines showed low levels.…”

Section: Discussionmentioning

confidence: 95%

Structural and Topographic Dynamics of Pulmonary Histopathology and Local Cytokine Profiles in Paracoccidioides brasiliensis Conidia-Infected Mice

et al. 2011

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BackgroundParacoccidioidomycosis (PCM), an endemic systemic mycosis caused by the fungus Paracoccidioides brasiliensis (Pb), usually results in severe lung damage in patients.Methods and FindingsConsidering the difficulties to sequentially study the infection in humans, this work was done in mice inoculated intranasally with infective Pb-conidia. Lungs of control and Pb-infected mice were studied after 2-hours, 4, 8, 12 and 16-weeks post-infection (p.i) in order to define histopathologic patterns of pulmonary lesions, multiplex-cytokine profiles and their dynamics during the course of this mycosis. Besides the nodular/granulomatous lesions previously informed, results revealed additional non-formerly described lung abnormalities, such as periarterial sheath inflammation and pseudotumoral masses. The following chronologic stages occurring during the course of the experimental infection were defined: Stage one (2-hours p.i): mild septal infiltration composed by neutrophils and macrophages accompanied by an intense “cytokine burst” represented by significant increases in IL-1α, IL-1β, IL-4, IL-5, IL-6, IL-10, IL12p70, IL-13, IL-17, Eotaxin, G-CSF, MCP1, MIP1α, GM-CSF, IFN-γ, MIP1β and TNFα levels. Stage two (4-weeks p.i): presence of nodules, evidence of incipient periarterial- and intense but disperse parenchymal- inflammation, abnormalities that continued to be accompanied by hyper-secretion of those cytokines and chemokines mentioned in the first stage of infection. Stages three and four (8 and 12-weeks p.i.): fungal proliferation, inflammation and collagenesis reached their highest intensity with particular involvement of the periarterial space. Paradoxically, lung cytokines and chemokines were down-regulated with significant decreases in IL-2,IL-3,IL-5,IL-9,IL-13,IL-15,GM-CSF,IFN-γ,MIP1β and TNFα. Stage five (16-weeks p.i.): inflammation decreased becoming limited to the pseudotumoral masses and was accompanied by a “silent” cytokine response, except for PDGF, MIG, RANTES and IL12p40 which remained up-regulated for the duration of the experiment.ConclusionsResults of this study identified both classic and novel patterns corresponding to histopathologic and immunologic responses occurring during the course of experimental PCM.

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Serum levels of sTNF-R1, sTNF-R2 and CXCL9 correlate with disease activity in adult type paracoccidioidomycosis

Cited by 13 publications

References 34 publications

Important aspects of oral paracoccidioidomycosis–a literature review

Important aspects of oral paracoccidioidomycosis–a literature review

Imunologia da paracoccidioidomicose

Structural and Topographic Dynamics of Pulmonary Histopathology and Local Cytokine Profiles in Paracoccidioides brasiliensis Conidia-Infected Mice

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