Serum levels of superoxide dismutases in patients with benign paroxysmal positional vertigo

Abstract

Objective: To investigate the possible role of superoxide dismutases (SODs) in the development of benign paroxysmal positional vertigo (BPPV) and recurrence events in a 1-year follow-up study. Methods: This was a prospective one-center study. A total of 204 patients with BPPV and 120 age-and sex matched healthy subjects were included. The levels of SOD between patients and control cases were compared. The levels of SOD between posterior semicircular canal (PSC) and horizontal semicircular canal (HSC) were also compared. In the 1-year follow-up, recurrence events were confirmed. The influence of SOD levels on BPPV and recurrent BPPV were performed by binary logistic regression analysis. Results: The serum levels of SOD in patients with BPPV were lower than in those control cases (P<0.001). Levels of SOD did not differ in patients with PSC and HSC (P=0.42). As a categorical variable, for per interquartile range (IQR) increment of serum level of SOD, the unadjusted and adjusted risks of BPPV would be decreased by 72% (with the odds ratio [OR] of 0.28 [95% confidence interval (CI): 0.21–0.37], P<0.001) and 43% (0.57 [0.42–0.69], P<0.001), respectively. Recurrent attacks of BPPV were reported in 50 patients (24.5%). Patients with recurrent BPPV had lower levels of SOD than in patients without (P<0.001). For per IQR increment of serum level of SOD, the unadjusted and adjusted risks of BPPV would be decreased by 51% (with the OR of 0.49 [95% CI: 0.36–0.68], P<0.001) and 24% (0.76 [0.60–0.83], P<0.001), respectively. Conclusion: Reduced serum levels of SOD were associated with higher risk of BPPV and BPPV recurrence events.

Prevention of Recurrent Benign Paroxysmal Positional Vertigo: The Role of Combined Supplementation with Vitamin D and Antioxidants

“…The role of oxidative stress in BPPV has been demonstrated with increased expression of VCAM-1 and d-ROM, which confirms angiitis’s existence and supports vascular involvement in BPPV [ 44 , 45 , 46 ]. Furthermore, identifying high levels of d-ROM and VCAM-1 could suggest the usefulness of a drug treatment aimed at correcting oxidative stress and activating endothelial cells [ 22 , 23 ].…”

An evaluation of trace elements and oxidative stress in patients with benign paroxysmal positional vertigo

“…There are studies explaining that the inflammatory process and oxidative stress formation play a role in the development of vertigo [ 17 ]. İn a study, researchers indicated that calcium metabolism and its relationship with oxidative stress may play a role in the development of BPPV [ 18 ].…”

Examining Migraine as a Predictor of Benign Paroxysmal Positional Vertigo Onset, Severity, Recurrence, and Associated Falls

“…Ishiyama et al proposed that migraine causes recurrent vasospasms that damage the vasculature of the inner ear, which may in turn displace the otoconia from the otolith organs [ 13 ]. This connection is further supported by the fact that repeated vasospasms cause oxidative stress, and decreased levels of superoxide dismutase (SOD), an antioxidant protein, have been observed in both migraine and BPPV [ 16 - 18 ]. Additionally, calcitonin gene-related peptide (CGRP), a neuroactive peptide that is released by trigeminal nerves during migraine attacks [ 19 ], may represent another pathophysiological link.…”