Serum Levels of Syndecan-1 in Patients With Kawasaki Disease

Luo, Li; Feng, Suhua; Wu, Yan; Su, Ya; Jing, Fengchuan; Yi, Qijian

doi:10.1097/inf.0000000000002047

Cited by 26 publications

(15 citation statements)

References 39 publications

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“…Anemia is a common clinical feature in KD patients [31]. In the current study, anemia was more common in the atypical patients than in the typical group.…”

Section: Discussionsupporting

confidence: 46%

Comparison of Clinical Symptoms and Cardiac Lesions in Children with Typical and Atypical Kawasaki Disease

2019

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The present study was performed to evaluate the clinical symptoms and cardiovascular complications in patients with typical and atypical Kawasaki disease (KD). This retrospective study was conducted on the medical records of 176 patients with KD for three years. The study population was divided into two groups of typical and atypical based on the KD clinical criteria. The two groups were compared in terms of demographic data, clinical symptoms, cardiac lesions, and laboratory markers. Based on the diagnostic criteria, 105 (60%) and 71 (40%) patients were diagnosed with typical and atypical KD, respectively. The mean age of the typical patients (38.16 months) was higher than that of the atypical group (24.03 months) at the time of diagnosis (p < 0.05). The results revealed no significant difference between the two groups regarding the seasonal distribution of KD onset (p = 0.422). However, the most common season for the diagnosis of the disease was spring, followed by winter. There was no significant difference between the two groups in terms of fever duration (p = 0.39). Furthermore, vomiting was more common in the atypical patients than in the typical group (p = 0.017). In terms of the cardiac lesions, ectasia (p = 0.005) and lack of tapering of the distal coronary vessels (p = 0.015) were more frequently detected in the atypical group than in the typical group. Considering the laboratory findings, thrombocytosis (p = 0.010) and anemia (p = 0.048) were more common in the atypical group, compared to those in the typical group. On the other hand, the typical group had a higher serum alanine aminotransferase level (adjusted for age) (p = 0.012) and Hyponatremia (serum sodium concentration ≤130 mmol/L) (p = 0.034). Based on the findings of the current study, the fever duration from onset to diagnosis was slightly more in atypical KD patients than in the typical group, but not statistically significant, possibly due to more timely diagnosis of atypical KD. There was no difference in coronary aneurysm between the two groups at the time of diagnosis. The atypical group had a higher frequency of coronary ectasia and lack of tapering, indicating cardiac involvement. Consequently, these conditions should be given more attention in the atypical patients. Furthermore, the higher frequency of anemia and thrombocytosis in the atypical patients can be useful for diagnosis of this kind of KD.

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“…Anemia is a common clinical feature in KD patients [31]. In the current study, anemia was more common in the atypical patients than in the typical group.…”

Section: Discussionsupporting

confidence: 46%

Comparison of Clinical Symptoms and Cardiac Lesions in Children with Typical and Atypical Kawasaki Disease

2019

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“…Similar to our COVID-19 case patient, elevated resistin is found in plasma from KD patients (17,18). Post-IVIg therapy, 3-5 days, plasma resistin levels in KD patients significantly decreased (12).…”

Section: Discussionsupporting

confidence: 85%

Case Report: Inflammation and Endothelial Injury Profiling of COVID-19 Pediatric Multisystem Inflammatory Syndrome (MIS-C)

et al. 2021

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Introduction: COVID-19 is associated with a novel multi-system inflammatory syndrome that shares some characteristics with Kawasaki's Disease. The syndrome manifestation is delayed relative to COVID-19 onset, with a spectrum of clinical severity. Clinical signs may include persistent fever, gastrointestinal symptoms, cardiac inflammation and/or shock.Case Presentation: We measured 59 inflammatory and endothelial injury plasma analytes in an adolescent girl that presented with malaise, fever, cough, strawberry tongue and jaundice. Her COVID-19 status was positive with detection of 2 SARS-CoV-2 viral genes using polymerase chain reaction. She was treated with intravenous immunoglobulin prior to blood draw, but our plasma measurements suggested a unique analyte expression pattern associated with inflammation, endothelial injury and microvascular glycocalyx degradation.Conclusions: COVID-19 is associated with a multi-system inflammatory syndrome and a unique inflammatory and endothelial injury signature.Summary: Analyte markers of inflammation and endothelial cell injury might serve as putative biomarkers and/or be investigated further as potential therapeutic targets.

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“…It has been shown that in the acute phase of Kawasaki disease, circulating levels of VEGLX (syndecan-1 and hyaluronic acid) are significantly elevated, and serum hyaluronic acid is the most useful prognostic biomarker for predicting future onset or exacerbation of coronary artery lesions in Kawasaki disease [ 46 ]. Serum levels of soluble syndecan-1, one of the major core proteins expressed in the VEGLX, are thought to reflect vascular endothelial damage and inflammation in Kawasaki disease [ 81 ]. Considering the common pathogenesis of Kawasaki disease and COVID-19, VEGLX damage has been suggested to be a biomarker in Kawasaki disease, and glycocalyx-associated biomarkers will likely contribute to the early detection of severe cases of COVID-19 in children and young adults, whose incidence of the disease is rare, but are prone to severe illnesses once they develop.…”

Section: Kawasaki Disease Shock Syndrome and Veglxmentioning

confidence: 99%

Vascular Endothelial Glycocalyx Damage in COVID-19

Yamaoka‐Tojo

2020

IJMS

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The new coronavirus disease-2019 (COVID-19), which is spreading around the world and threatening people, is easily infecting a large number of people through airborne droplets; moreover, patients with hypertension, diabetes, obesity, and cardiovascular disease are more likely to experience severe conditions. Vascular endothelial dysfunction has been suggested as a common feature of high-risk patients prone to severe COVID-19, and measurement of vascular endothelial function may be recommended for predicting severe conditions in high-risk patients with COVID-19. However, fragmented vascular endothelial glycocalyx (VEGLX) is elevated in COVID-19 patients, suggesting that it may be useful as a prognostic indicator. Although the relationship between VEGLX and severe acute respiratory syndrome coronavirus 2 infections has not been well studied, some investigations into COVID-19 have clarified the relationship between VEGLX and the mechanism that leads to severe conditions. Clarifying the usefulness of VEGLX assessment as a predictive indicator of the development of severe complications is important as a strategy for confronting pandemics caused by new viruses with a high affinity for the vascular endothelium that may recur in the future.

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Serum Levels of Syndecan-1 in Patients With Kawasaki Disease

Abstract: SDC-1 serum levels may mirror vascular endothelial damage and inflammation in KD. This might be utilized as a potential novel target for coronary artery protection in KD patients.

Cited by 26 publications

References 39 publications

Comparison of Clinical Symptoms and Cardiac Lesions in Children with Typical and Atypical Kawasaki Disease

Comparison of Clinical Symptoms and Cardiac Lesions in Children with Typical and Atypical Kawasaki Disease

Case Report: Inflammation and Endothelial Injury Profiling of COVID-19 Pediatric Multisystem Inflammatory Syndrome (MIS-C)

Vascular Endothelial Glycocalyx Damage in COVID-19

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