Serum levels of the IgA isotype switch factor TGF‐β1 are elevated in patients with COVID‐19

Wang, Eryi; Chen, Hao; Sun, Baoqing; Wang, Hui; Qu, Hui‐Qi; Liu, Yichuan; Sun, Xizhuo; Qu, Jingchun; Zheng, Fang; Tian, Lifeng; Zeng, Yutian; Huang, Shau‐Ku; Hákonarson, Hákon; Liu, Zhigang

doi:10.1002/1873-3468.14104

Cited by 23 publications

(23 citation statements)

References 25 publications

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“…Eccles et al in their studies also provided evidence both for the overlap between hypermobile Ehlers–Danlos syndrome and FM, as well as between FM and CFS (up to 90%), which may allude that, that disease may be a part of one spectrum [ 18 , 19 ]. In addition, in patients with the Marfanoid phenotype, a high level of TGF beta1-beta2 can be expected, which worsens the clinical course and prognosis of COVID-19 [ 20 , 21 , 22 ].…”

Section: Clinical Case №mentioning

confidence: 99%

New Clinical Phenotype of the Post-Covid Syndrome: Fibromyalgia and Joint Hypermobility Condition

et al. 2022

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Fibromyalgia can be defined as a chronic pain condition, affecting the musculoskeletal system, etiology and pathophysiology of which is sufficiently understudied. Despite the fact that many authors consider this entity to be a manifestation of central sensitization, and not an autoimmune disease, the high prevalence of fibromyalgia in patients with post-COVID-19 conditions requires taking a fresh look at the causes of the disease development. During the patient examination, the authors identified a combination of symptoms that occurs so often, that they can be carefully described as a clinical pattern. These manifestations include young age, female gender, joint hypermobility, the onset of pain after COVID-19, physical traumatization of one particular tendon and the development of the fibromyalgia pain syndrome during the next several weeks. As well as an increase in the titer of antinuclear antibodies and some other systemic inflammation factors. It can be assumed with great caution that local damage to the connective tissue in patients with joint hypermobility, having COVID-19 as a trigger factor can lead to the development of fibromyalgia syndrome. This article presents three clinical cases that illustrated this hypothesis.

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Section: Clinical Case №mentioning

confidence: 99%

New Clinical Phenotype of the Post-Covid Syndrome: Fibromyalgia and Joint Hypermobility Condition

et al. 2022

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“…It is known that TGF‐β1 plays an important role in tissue regeneration, tumorigenesis, and immune response. In respiratory disease, it has been revealed that it causes the proliferation of fibroblast, leading to pulmonary fibrosis 65 . In a study of 153 patients with COVID‐19, Wang et al.…”

Section: Overlap Between Common Symptoms Of Varicocele and Known Risk...mentioning

confidence: 99%

“…In a study of 153 patients with COVID‐19, Wang et al. found that the plasma levels of TGF‐β1 increased significantly in early and middle stages of the disease 65 . They assumed that TGF‐β1 has a key role in COVID‐19 pathogenesis.…”

Section: Overlap Between Common Symptoms Of Varicocele and Known Risk...mentioning

confidence: 99%

COVID‐19 and varicocele: The possible overlap factors and the common therapeutic approaches

Mahdavinezhad

Farmani

Pakniat

et al. 2022

American J Rep Immunol

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Varicocele is recognized as one of the main attributable causes of male infertility which can affect spermatogenesis by various pathophysiological mechanisms. Recent studies have identified oxidative stress and reduction in antioxidant, hyperthermia, hypoxia, hormonal dysfunction, and inflammatory conditions as major factors in the pathophysiology of varicocele, all of which have known direct associations with the coronavirus disease 2019 (COVID-19) and can significantly increase the risk of detrimental COVID-19-related outcomes. Emerging data have shown an association between COVID-19 and inflammation, overproduction of cytokine, and other pathophysiological processes. The present review, summarizes the current understanding of the pathophysiology of varicocele and investigates the potential correlation between the severity of COVID-19 and the varicocele disease. In addition, various possible treatments which can be effective in both diseases were examined. Despite numerous challenges associated with the prevalence of COVID-19 in healthcare systems in infected countries, special attention should be given to maintaining a high level of care for complex patients with a pre-existing disease such as varicocele and providing appropriate practical advice for optimal control of the COVID-19 disease.

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“…The latter includes transforming growth factor (TGF) beta 1, possibly depending on the TGF-beta1 activator THBS3, which is genetically associated with severe COVID-19 cases, as suggested by the COVID-19 Host Genetics Initiative (https://www.covid19hg.org). This topic is highlighted in the study by Wang et al [42]. Whether it relates to the increased COVID-19 risk in patients suffering from inheritable mucopolysaccharidosis (MPS) and thickened mucus in the lungs is unknown.…”

Section: Host-directed Antiviralsmentioning

confidence: 99%

“…This topic is highlighted in the study by Wang et al . [42]. Whether it relates to the increased COVID‐19 risk in patients suffering from inheritable mucopolysaccharidosis (MPS) and thickened mucus in the lungs is unknown.…”

Section: Host‐directed Antiviralsmentioning

confidence: 99%

Two years into COVID‐19 – Lessons in SARS‐CoV‐2 and a perspective from papers in FEBS Letters

Greber

2021

FEBS Letters

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The 2019 outbreak of coronavirus disease in Wuhan (Hubei province of China) has given rise to a pandemic spread of virus, more than 240 million incidences and a death toll larger than 5 million people. COVID-19 has set off large efforts in research, therapy and patient care, as well as public and private debates in every imaginable form. A number of scientists used the publication platforms provided by the Federation of the European Biochemical Societies (FEBS) to present their research data, reviews, opinions and other contributions relating to COVID-19 and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, I highlight the recent COVID-19 papers which have been published and collected in a Virtual Issue in FEBS Letters, and discuss their implications towards understanding the molecular, biochemical and cellular mechanisms of SARS-CoV-2 infections, vaccine development and antiviral discovery strategies.

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Serum levels of the IgA isotype switch factor TGF‐β1 are elevated in patients with COVID‐19

Cited by 23 publications

References 25 publications

New Clinical Phenotype of the Post-Covid Syndrome: Fibromyalgia and Joint Hypermobility Condition

New Clinical Phenotype of the Post-Covid Syndrome: Fibromyalgia and Joint Hypermobility Condition

COVID‐19 and varicocele: The possible overlap factors and the common therapeutic approaches

Two years into COVID‐19 – Lessons in SARS‐CoV‐2 and a perspective from papers in FEBS Letters

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