Serum levels of TNF-alpha and spirometric parameters in workers exposed to inorganic dust

Prakova, G.; Gidikova, P.; Sandeva, G.; Haracherova, K.; Stanilova, K.

doi:10.15547/tjs.2015.04.006

Cited by 2 publications

(2 citation statements)

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“…Consistent with our findings, Prakova et al reported serum neopterin levels to be high in miners exposed to asbestos and coal dust. 41 Increased neopterin levels have also been reported in miners exposed to bauxite dust, 42 while another study has suggested that levels are increased in tuberculosis which may be associated with the stimulation of cellular immune response. 43 Workers exposed to dust containing free crystalline silicon dioxide were found to have higher neopterin levels compared to the control group.…”

Section: Discussionmentioning

confidence: 97%

The usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma

et al. 2021

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Introduction: Malignant pleural mesothelioma (MPM) is a malignant tumor that is associated mostly with asbestos exposure. The present study was to evaluates the diagnostic value of neopterin, periostin, YKL-40, Tenascin-C (TNC), and Indolamine 2,3-dioxygenase (IDO) as noninvasive markers of malign pleural mesothelioma. Methods: Included in the study were 30 patients diagnosed with malign pleural mesothelioma, and 25 people as a control group. Biomarker levels were determined using an enzyme immunoassay . A Mann-Whitney U test and Spearman correlation methods were used for the statistical analysis. Results: All evaluated biomarkers were found to be significantly higher in the MPM group than in the control group ( p < 0.05). There was no effect of such variables as gender, age or MPMsubtype on the parameters ( p > 0.05) in the patient group. All biomarkers were positively correlated with each other ( p < 0.001). Conclusions: The current non-invasive biomarkers that can be used in the diagnosis of MPM yielded significant results and can make important contributions to the early diagnosis of MPM.

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Section: Discussionmentioning

confidence: 97%

The usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma

et al. 2021

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“…Immune cells interact with antigens which lead to the release of chemical substances called cytokines that affect other cells and coordinate appropriate immune responses. Cytokines include interleukins, interferons, growth factors, monokines, and lymphokines (Prakova et al, 2015). Measurement of soluble cytokines in vivo and in vitro is becoming increasingly important in studying and controlling pulmonary diseases (Chowdhury et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

IMPACT OF DUST EXPOSURE AMONG STONE QUARRY WORKERS ON VENTILATORY FUNCTIONS AND SERUM LEVEL OF TUMOUR NECROSIS FACTOR- ALPHA (TNF-α)

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Gh³

2018

Egypt. J. Occup. Med.

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Introduction: The health impacts of working in stone quarrying industry have been well documented. Inhalable dust is produced when the stone is cut and by the breaking of the stones on the quarry floor during the transit of the vehicles. A particular concern in some quarries is the inhalation of dust containing silica which can lead to silicosis. Workers exposed to high intensity of dust would have increased Tumour Necrosis Factor-Alpha (TNF-α) in serum which is a strong indicator in predicting the prognosis of pneumoconiosis. Aim of work: To find out the relation between serum levels of TNF-α and some spirometric parameters in workers exposed to stone dust during quarrying. Materials and Methods: Fifty five workers who were exposed to stone dust in quarrying industry participated in the study. A control group of 55 individuals were randomly selected to be matched with the exposed group as regards age, gender, and special habits of medical importance and not exposed to dust. Full medical history and clinical examination were carried out to all participants. Ventilatory function tests (FVC%, FEV1%, FEV1/FVC%, PEF%, FEF25%, FEF50% and FEF75%) and serum level of TNF-α were measured for both groups. Results: There were mild to moderate restrictive ventilatory impairment and mild obstructive impairment among the exposed group (statistically highly significant (p<0.001) when compared to the control. Serum levels of TNF-α were significantly higher among the exposed than the control group. Duration of exposure to dust negatively correlated with spirometric parameters and positively correlated with the serum level of TNF-α among the exposed group. Also the latter negatively correlated with spirometric parameters. Conclusion: Serum TNF-α can be used as a biomarker for detection and follow up of pneumoconiosis in workers exposed to stone dust in quarrying industry.

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Serum levels of TNF-alpha and spirometric parameters in workers exposed to inorganic dust

Cited by 2 publications

References 10 publications

The usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma

The usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma

IMPACT OF DUST EXPOSURE AMONG STONE QUARRY WORKERS ON VENTILATORY FUNCTIONS AND SERUM LEVEL OF TUMOUR NECROSIS FACTOR- ALPHA (TNF-α)

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