1979
DOI: 10.3109/00016347909154578
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Serum Levels of Total Dehydroepiandrosterone and Total Estrone in Postmenopausal Women with Special Regard to Carcinoma of the Uterine Corpus

Abstract: Serum levels of total dehydroepiandrosterone and total estrone were determined in 18 postmenopausal women with carcinoma of the uterine corpus (stage I, grade 1-3) and in 40 healthy postmenopausal women. Elevated levels of both steroids were found in the carcinoma group, for dehydroepiandrosterone 2010+/-195 vs. 1299+/-117 nM, p less than 0.01, and for estrone 2,38+/-0.24 vs. 1.36+/-0.11 nM, p less than 0.001. Dehydroepiandrosterone as well as the precursors of estrone are almost exclusively of adrenal origin … Show more

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Cited by 27 publications
(11 citation statements)
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“…The intra-and interassay variation coefficients were 4.5 and 7%, respectively. DHEA, DHEAS, 17-OHP, and androstenedione were analyzed by radioimmunoassay after extraction with diethyl ether [22][23][24]. In the assay of DHEAS, the sulfoconjugate was cleaved by thermal hydrolysis prior to extraction.…”
Section: Hormone Assaysmentioning
confidence: 99%
“…The intra-and interassay variation coefficients were 4.5 and 7%, respectively. DHEA, DHEAS, 17-OHP, and androstenedione were analyzed by radioimmunoassay after extraction with diethyl ether [22][23][24]. In the assay of DHEAS, the sulfoconjugate was cleaved by thermal hydrolysis prior to extraction.…”
Section: Hormone Assaysmentioning
confidence: 99%
“…The method included hydrolysis of DHAS by autoclaving diluted serum at pH 4.5 and 120°C for 75 min, extraction of liber ated DHA by diethylether and radioimmunoassay using anti-DHA-15P (carboxyethylmercapto)-bovine serum albumin (South West Foundation for Research and Education, San Antonio, Tex., USA) and tritiated DHA tracer. Details of the method have been given in a previous publication [8]. Least detectable DHAS concentration was 200 nA/ and intra-and interassay variations were 8 and 12%, respectively.…”
Section: Methodsmentioning
confidence: 99%
“…Venous blood samples were taken between 09.00 and 11.00 a.m. and serum was stored at -2 0°C until analysis. Serum DHAS was determined by a modification of the method described by Metcalf [8,13]. The method included hydrolysis of DHAS by autoclaving diluted serum at pH 4.5 and 120°C for 75 min, extraction of liber ated DHA by diethylether and radioimmunoassay using anti-DHA-15P (carboxyethylmercapto)-bovine serum albumin (South West Foundation for Research and Education, San Antonio, Tex., USA) and tritiated DHA tracer.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Serum concentrations of déhydroépiandrostérone (DHA), dehydroepiandrosterone sulfate (DHAS) and 4-androstene-3,17-dione (A-4) were analyzed after extraction with diethyl ether by radioimmunological methods developed at our department [8][9][10][11], using the antibodies specified by Stege et al [11]. In the DHAS assay, thermal hydrolysis of DHAS preceded the extraction.…”
Section: Methodsmentioning
confidence: 99%