Serum levels of trace metals in children with atopic eczema

David, T J; Wells, F. E.; Sharpe, T.C.; Gibbs, A. R.; Devlin, J.

doi:10.1111/j.1365-2133.1990.tb14725.x

Cited by 40 publications

(35 citation statements)

References 12 publications

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“…Until now, a few contradictory results have been reported about the levels of zinc in atopic patients compared to control (4)(5)(6). Di Toro et al (25) found no differences in serum levels, although zinc levels in hair were lower in patients with AD.…”

Section: Discussionmentioning

confidence: 93%

“…Although the relationship between zinc deficiency and atopic dermatitis (AD) is not clear, a zinc deficient diet induced AD-like eruptions and deterioration of skin barrier function in DS-Nh mice (3). In some studies, serum zinc levels were lower in children with AD than in controls (4)(5)(6). Moreover, the reductions in serum zinc levels in AD did not correlate with the severity of eczema and might be interpreted as non-specific findings accompanying the skin disorder (5).…”

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confidence: 98%

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Hair Zinc Levels and the Efficacy of Oral Zinc Supplementation in Patients with Atopic Dermatitis

Kim¹,

Yoo²,

Jeong³

et al. 2014

Acta Derm Venerol

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Zinc deficiency in patients with atopic dermatitis (AD) and the use of zinc supplementation is still controversial. We measured hair zinc levels in 58 children with AD and 43 controls (age range 2-14 years). We also investigated the efficacy of oral zinc supplementation in AD patients with low hair zinc levels by comparing eczema assessment severity index (EASI), transepidermal water loss (TEWL), and visual analogue scales for pruritus and sleep disturbance in patients receiving zinc supplementation (Group A) and others not receiving supplementation (Group B). At baseline, the mean zinc level was significantly reduced in AD patients (113.1 μg/g vs. 130.9 μg/g, p = 0.012). After 8 weeks of supplement, hair zinc level increased significantly in Group A (p < 0.001), and EASI scores, TEWL, and visual analogue scales for pruritus improved more in Group A than in Group B (p = 0.044, 0.015 and < 0.001, respectively). Thus, oral zinc supplementation may be effective in AD patients with low hair zinc levels.

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Section: Discussionmentioning

confidence: 93%

mentioning

confidence: 98%

Hair Zinc Levels and the Efficacy of Oral Zinc Supplementation in Patients with Atopic Dermatitis

Kim¹,

Yoo²,

Jeong³

et al. 2014

Acta Derm Venerol

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“…The release of potentially harmful free transit iron within the cells will clearly exacerbate the damaging effects of photoperoxidation and is likely to be of central importance to both reversible and degenerative/pathological events that follow exposure to solar UV radiation. The presence of excess iron has also been demonstrated in a variety of skin pathologies that involve inflammatory responses such as psoriasis (Molin and Wester, 1973) and atopic eczema (Weintraub et al, 1965;David et al, 1990).…”

mentioning

confidence: 97%

Ultraviolet A Radiation-Induced Immediate Iron Release Is a Key Modulator of the Activation of NF-κB in Human Skin Fibroblasts

Reelfs

Tyrrell

Pourzand

2004

Journal of Investigative Dermatology

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Ultraviolet A (UVA, 320-400 nm) radiation, an oxidizing component of sunlight, leads to an immediate increase in the labile iron in human skin fibroblasts. Exposure of skin fibroblasts to UVA radiation is also known to induce nuclear factor-kappaB (NF-kappaB) DNA-binding activity, although the underlying mechanism is unclear. We report here that in skin fibroblasts, the extent of NF-kappaB activation by UVA tightly correlates with the level of "UVA-induced" labile iron release as shown by both iron chelation and iron loading treatments. Furthermore, our data indicate that the slow kinetics of induction of NF-kappaB by UVA relative to other oxidants previously studied is due to a transient increase in permeability of nuclear membrane to proteins and occurs as a result of labile iron-mediated damage to nuclear membrane. Since in addition to iron chelators, lipid peroxidation inhibitors also decrease the UVA-mediated induction of NF-kappaB, we propose that the rapid release of labile iron by UVA might act as a catalyst to exacerbate the generation of lipid secondary messengers in skin cell membranes that are responsible for induction of NF-kappaB. This novel role for iron in amplifying NF-kappaB mobilization in response to UVA-induced oxidative stress aids understanding of its involvement in UV-induced skin inflammation.

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“…There are conflicting results in serum levels of zinc in patients with AD: some authors reported lower levels [5, 6] whereas others found no differences [7, 8]. Free zinc is predominantly inside the cells and required zinc can be provided by the plasma.…”

Section: Introductionmentioning

confidence: 99%

Erythrocyte zinc level in patients with atopic dermatitis and its relation to SCORAD index

Karabacak

Aydın

Kutlu

et al. 2016

pdia

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IntroductionAtopic dermatitis (AD) is a chronic, pruritic inflammatory disease, characterized by a relapsing-remitting course. The pathogenesis of atopic dermatitis is not completely understood, although the disorder appears to result from the complex interaction between immune abnormalities, genetic and environmental factors. Trace elements are essential for normal functioning of the immune system.AimTo determine zinc levels in serum and erythrocytes of patients with AD using an atomic absorption spectrometric technique and to investigate the relationship between those levels and disease activity.Material and methodsSixty-seven patients and 49 controls were enrolled into the study. The disease severity of AD patients was determined according to the Scoring Atopic Dermatitis (SCORAD) index. We measured zinc levels in serum and erythrocytes by the atomic absorption spectrophotometric technique.ResultsErythrocyte zinc levels were significantly lower in AD patients than in the control group (p < 0.001), whereas serum zinc levels did not differ between the groups (p = 0.148). In the AD patient group there was a negative correlation between the SCORAD score and erythrocyte zinc levels (r = –0.791; p < 0.001).ConclusionsThe negative relationship between disease severity and erythrocyte zinc levels might suggest an immunopathological link between AD progression and intracellular zinc metabolism.

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Serum levels of trace metals in children with atopic eczema

Cited by 40 publications

References 12 publications

Hair Zinc Levels and the Efficacy of Oral Zinc Supplementation in Patients with Atopic Dermatitis

Hair Zinc Levels and the Efficacy of Oral Zinc Supplementation in Patients with Atopic Dermatitis

Ultraviolet A Radiation-Induced Immediate Iron Release Is a Key Modulator of the Activation of NF-κB in Human Skin Fibroblasts

Erythrocyte zinc level in patients with atopic dermatitis and its relation to SCORAD index

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