Serum levels of vitamin A, selenium, and better dietary total antioxidant capacity are related to lower oxidative DNA damage: A cross-sectional study of individuals at cardiovascular risk

Lima-Reis, Sílvia Regina de; Silva, Thamires Aguiar; Costa, Letícia Sayuri Adama; Volp, Ana Carolina Pinheiro; Rios-Santos, Fabrício; Reis, Érica Melo; Bassi-Branco, Carmen Lucia

doi:10.1016/j.jnutbio.2022.109070

Cited by 4 publications

(2 citation statements)

References 47 publications

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“…In a large cross-sectional study, DTAC, measured by the FRAP method, was inversely associated with the hypertriglyceridemic waist phenotype and amputation due to arterial disease in people undergoing secondary care for CVDs [ 12 ]. In another cross-sectional study, high DTAC, measured by the FRAP method, had a protective effect against oxidative DNA damage in individuals at cardiovascular risk [ 51 ]. Findings from a meta-analysis of prospective cohort studies have shown that high DTAC was associated with a lower risk of mortality from all causes, cancer, and CVDs.…”

Section: Discussionmentioning

confidence: 99%

Dietary Total Antioxidant Capacity—A New Indicator of Healthy Diet Quality in Cardiovascular Diseases: A Polish Cross-Sectional Study

et al. 2022

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This study aimed to assess the relationship between the dietary total antioxidant capacity (DTAC) and the occurrence of cardiovascular diseases (CVDs), as well as healthy diet quality, in a representative sample (n = 5690) of the whole Polish adult population (WOBASZ II study). Daily food consumption was estimated by the single 24 h dietary recall method. Antioxidant vitamins (C, E, and β-carotene) and minerals (Zn, Fe, Mn, and Cu) from the diet and supplements were calculated using 5D Diet software, and dietary total polyphenol intake (DTPI) was determined using the Phenol-Explorer database and our database. Total diet quality was measured by the Healthy Diet Indicator (HDI) based on World Health Organization (WHO) recommendations for the prevention of CVD. DTAC was calculated using the data on food consumption and the antioxidant potential of foods measured by the FRAP (ferric ion reducing antioxidant potential) method. It was shown that higher DTAC was associated with a higher intake of polyphenols, antioxidant vitamins, and minerals. Moreover, a higher quartile of DTAC was associated with a reduced odds ratio for cardiovascular diseases in a Polish population, as well as with a higher HDI. Therefore, dietary recommendations for the prevention and therapy of CVDs should take into account a high DTAC. DTAC, measured by the FRAP method, can be considered an indicator of healthy diet quality.

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Section: Discussionmentioning

confidence: 99%

Dietary Total Antioxidant Capacity—A New Indicator of Healthy Diet Quality in Cardiovascular Diseases: A Polish Cross-Sectional Study

et al. 2022

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“…Therefore, the balance between the formation of ROS and their elimination by scavenging systems plays a key role in cell physiology. In this approach, both natural and synthetic antioxidants have received much attention from a pharmaceutical and food chemistry viewpoint due to their proven health-promoting effects [2][3][4][5] .…”

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confidence: 99%

New C8-substituted caffeine derivatives as promising antioxidants and cytoprotective agents in human erythrocytes

Sierakowska

Jasiewicz

Piosik

et al. 2023

Sci Rep

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New structurally diverse groups of C8-substituted caffeine derivatives were synthesized and evaluated for their chemical and biological properties. Mass spectrometry, FT-IR, and NMR characterizations of these derivatives were performed. The cytotoxic activity of the derivatives was estimated in vitro using human red blood cells (RBC) and in silico pharmacokinetic studies. The antioxidant capacity of the compounds was analyzed using a ferrous ion chelating activity assay. The ability of the derivatives to protect RBC from oxidative damage, including the oxidation of hemoglobin to methemoglobin, was assessed using a water-soluble 2,2′-azobis(2-methyl-propionamidine) dihydrochloride (AAPH) as a standard inducer of peroxyl radicals. The level of intracellular oxidative stress was assessed using the fluorescent redox probe 2′,7′-dichlorodihydrofluorescein diacetate (DCF-DA). The results indicate that all derivatives are biocompatible compounds with significant antioxidant and cytoprotective potential dependent on their chemical structure. In order to explain the antioxidant and cytoprotective activity of the derivatives, a mechanism of hydrogen atom transfer (HAT), radical adduct formation (RAF), or single electron transfer (SET), as well as the specific interactions of the derivatives with the lipid bilayer of RBC membrane, have been proposed. The results show that selected modifications of the caffeine molecule enhance its antioxidant properties, which expands our knowledge of the structure–activity relationship of caffeine-based cytoprotective compounds.

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Association between composite dietary antioxidant index and atherosclerosis cardiovascular disease in adults: A cross-sectional study

Lin,

Xie,

Lin

et al. 2024

Nutrition, Metabolism and Cardiovascular Diseases

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Serum levels of vitamin A, selenium, and better dietary total antioxidant capacity are related to lower oxidative DNA damage: A cross-sectional study of individuals at cardiovascular risk

Cited by 4 publications

References 47 publications

Dietary Total Antioxidant Capacity—A New Indicator of Healthy Diet Quality in Cardiovascular Diseases: A Polish Cross-Sectional Study

Dietary Total Antioxidant Capacity—A New Indicator of Healthy Diet Quality in Cardiovascular Diseases: A Polish Cross-Sectional Study

New C8-substituted caffeine derivatives as promising antioxidants and cytoprotective agents in human erythrocytes

Association between composite dietary antioxidant index and atherosclerosis cardiovascular disease in adults: A cross-sectional study

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