Serum levels of vitamin D, parathyroid hormone and calcium in relation to survival following breast cancer

Huss, Linnea; Butt, Salma; Borgquist, Signe; Almquist, Martin; Malm, Johan; Manjer, Jonas

doi:10.1007/s10552-014-0413-3

Cited by 26 publications

(26 citation statements)

References 52 publications

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“…In addition to a role in breast cancer incidence, pre-diagnostic calcium levels have additionally been reported to be associated with breast cancer mortality. Huss and colleagues [ 19 ] reported an inverse relation between pre-diagnostic levels of serum calcium and breast cancer mortality, with lower breast cancer-specific mortality in patients with serum calcium levels ≥2.44 mmol/L compared to those with lower levels of calcium (HR: 0.53, 95% CI: 0.30–0.92). However, this association was no longer seen in a sensitivity analysis excluding women diagnosed with breast cancer within two years from the date of baseline blood donation.…”

Section: Discussionmentioning

confidence: 99%

Serum Calcium and the Risk of Breast Cancer: Findings from the Swedish AMORIS Study and a Meta-Analysis of Prospective Studies

Wulaningsih

Sagoo

Hamza

et al. 2016

IJMS

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To investigate the association between serum calcium and risk of breast cancer using a large cohort and a systematic review with meta-analysis. From the Swedish Apolipoprotein Mortality Risk (AMORIS) Study we included 229,674 women who had baseline measurements of serum total calcium and albumin. Multivariable Cox regression was used to assess the association between total and albumin-corrected calcium and breast cancer risk. For the systematic review, an electronic search of MEDLINE and EMBASE databases was performed to identify other prospective cohorts assessing the relationship between serum calcium and breast cancer risk. We pooled the results of our AMORIS cohort with other eligible studies in a meta-analysis using a random effects model. I2 test was used to assess heterogeneity. In the AMORIS study, 10,863 women were diagnosed with breast cancer (mean follow-up: 19 years). We found an inverse association between total serum calcium and breast cancer when comparing the fourth quartile to the first quartile (HR: 0.94, 95% CI: 0.88–0.99, p value for trend 0.04) and similar results using albumin-corrected calcium. In the systematic review, we identified another two prospective cohorts evaluating pre-diagnostic serum total calcium and breast cancer. Combining these studies and our findings in AMORIS in a meta-analysis showed a protective effect of serum calcium against breast cancer, with a summary RR of 0.80 (95% CI: 0.66–0.97). No substantial heterogeneity was observed. Our findings in AMORIS and the meta-analysis support an inverse association between serum calcium and breast cancer risk, which warrants mechanistic investigations.

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Section: Discussionmentioning

confidence: 99%

Serum Calcium and the Risk of Breast Cancer: Findings from the Swedish AMORIS Study and a Meta-Analysis of Prospective Studies

Wulaningsih

Sagoo

Hamza

et al. 2016

IJMS

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“…PTH is secreted when calcium levels decrease. PTH stimulates release of calcium from bone into blood and synthesis of 1,25 dihydroxy vitamin D from its storage form 25hydroxy vitamin D.[ 36 , 37 ]…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status: A Different Story in the Very Young versus the Very Old Romanian Patients

et al. 2015

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BackgroundIn Romania (latitude 48°15’N to 43°40’N), vitamin D supplementation is common practice mostly in infants 0-1 year old. No published information is available regarding epidemiological data on vitamin D status in the Romanian population for a wide age range and geographical territory. In this context, we aimed to evaluate the seasonal and age variation of vitamin D status in a large Romanian population.Methods6631 individuals from across Romania had performed 7544 vitamin D assessments (2012-2014) in a chain of private laboratories. Vitamin D (25-hydroxyvitamin D2 and 25-hydroxyvitamin D3) was measured using High Performance Liquid Chromatography. Vitamin D levels were classified as severe deficiency<10ng/mL, deficiency 10-20ng/mL, insufficiency 21-29ng/mL, sufficiency≥30ng/mL and potentially harmful>100ng/ml.ResultsMale to female ratio was 1:2.9. Age ranged from 0 to 85 years. Mean vitamin D levels increased from April (26.3ng/ml) to September (35.6ng/ml) and decreased from October (33.5ng/ml) to March (24.4 ng/ml). Overall 40% had sufficient vitamin D, while the rest were insufficient 33%, deficient 22%, severely deficient 4% and 1% potentially harmful (of them 81% under 1 year old). Males compared to females showed higher percentages of sufficiency (47% vs. 38%). Children 0- 2 years presented the highest percentage of vitamin D sufficiency (77%). Lowest percentages (21%) of sufficiency were in people 80-84 years.ConclusionIn Romania, suboptimal vitamin D levels are common (59%), especially in older age, wintertime and in women. Vitamin D supplementation would be most warranted from January to April in the Romanian population. 25-hydroxyvitamin D levels>100ng/ml were relatively prevalent in children 0-1 year old (17.3%). This was attributed to supplementation errors and the fact that high-risk individuals were more likely to visit for medical check-up. Nonetheless, it stresses the need to increase awareness of the importance of preventing Vitamin D supplementation administration errors in the young.

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“…For example, higher prediagnostic vitamin D status was associated with significantly lower lung cancer mortality in the 2 Danish cohorts (Table 2) (73), but not with colorectal cancer mortality (73), and lung cancer mortality was not related to 25(OH)D in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (80). A U-shaped relationship was observed for prediagnostic 25(OH)D and breast cancer mortality in the Swedish Malmo cohort (81). On the basis of blood samples taken after diagnosis, a higher level of 25(OH)D was associated with a lower colorectal cancer mortality (82,83), ovarian cancer mortality (84), and Merkel cell carcinoma mortality (although not significant) (85).…”

Section: Or In the European Prospective Investigation Into Cancer Andmentioning

confidence: 99%

Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges

Mondul

Weinstein

Layne

et al. 2017

Epidemiologic Reviews

167

133

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There has been substantial enthusiasm recently regarding the potential role of vitamin D in the primary and secondary prevention of cancer. Laboratory studies demonstrate a range of anticarcinogenic effects for vitamin D compounds, but human studies have yielded little consistent evidence supporting a protective association. Higher circulating levels of vitamin D (i.e., 25-hydroxyvitamin D or 25(OH)D) appear to be associated with reduced risk of colorectal and bladder malignancies, but higher risk of prostate and possibly pancreatic cancers, with no clear association for most other organ sites examined. Despite there being no official institutional recommendations regarding the use of vitamin D supplements for cancer prevention, screenings for vitamin D deficiency and vitamin D supplement use have increased substantially over the past decade. These widespread practices demonstrate that population sociobehavioral changes are often adopted before scientifically well-informed policies and recommendations are available. This review critically examines the currently available epidemiologic literature regarding the associations between circulating 25(OH)D, vitamin D supplementation, and vitamin D-related genetic variation and cancer risk and mortality, with a particular emphasis on prospective studies. We identify several important gaps in our scientific knowledge that should be addressed in order to provide sufficient reproducible data to inform evidence-based recommendations related to optimal 25(OH)D concentrations (and any role for vitamin D supplementation) for the primary and secondary prevention of cancer. With few exceptions, such recommendations cannot be made at this time.

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Serum levels of vitamin D, parathyroid hormone and calcium in relation to survival following breast cancer

Cited by 26 publications

References 52 publications

Serum Calcium and the Risk of Breast Cancer: Findings from the Swedish AMORIS Study and a Meta-Analysis of Prospective Studies

Serum Calcium and the Risk of Breast Cancer: Findings from the Swedish AMORIS Study and a Meta-Analysis of Prospective Studies

Vitamin D Status: A Different Story in the Very Young versus the Very Old Romanian Patients

Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges

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