Serum levels of vitamin D and chronic periodontitis in patients with chronic kidney disease

Bastos, Jéssica do Amaral; Andrade, Luiz Carlos Ferreira de; Ferreira, Ana Paula; Barroso, Erica de Almeida; Daibert, Patrícia de Castro; Barreto, Patrícia Lima de Sá; Vilela, Eduardo Machado; Marcaccini, Andrea M.; Colugnati, Fernando Antônio Basile; Bastos, Marcus Gomes

doi:10.5935/01012800.20130004

Cited by 15 publications

(16 citation statements)

References 35 publications

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“…The interaction between molecular patterns of certain periodontopathic bacteria and TLR1/2 of innate oral immunocytes including monocytes/macrophages and keratinocytes may also induce the expression of VDR and the production of 1,25(OH) 2 D by these cells. In turn, the 1,25(OH) 2 D/VDR signalling induces the expression of genes encoding the antibacterial agents cathelicidin and β defencin [ 1 , 10 , 51 ] which may provide some protection against the development of bacterial plaque-induced chronic periodontitis [ 13 ].…”

Section: Periodontitismentioning

confidence: 99%

“…In progressive chronic periodontitis, dissemination of periodontopathic bacteria and of inflammatory mediators from the inflamed periodontal tissues is not uncommon. As a result, in a subset of genetically predisposed persons with upregulated immunoinflammatory responses, active chronic periodontitis can increase the risk of cardiovascular disease, stroke, inadequate glycaemic control in diabetes mellitus, and complications of pregnancy [ 1 , 4 ]. Indeed, it has been reported that after adjustment for confounding variables, compared to those with minimal periodontal disease, subjects with advanced periodontitis have a 25% increased risk of coronary heart disease [ 4 ].…”

Section: Periodontitismentioning

confidence: 99%

“…Chronic periodontitis is an inflammatory disease caused by dentogingival bacterial plaques and if left untreated, it causes progressive destruction of periodontal tissues, ultimately leading to tooth loss. In a subset of subjects with chronic periodontitis, there may be an increased risk of cardiovascular disease, diabetes mellitus, and complications of pregnancy [ 1 – 4 ]. Periodontitis affects up to 50% of the adult population [ 5 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Cross-sectional observational studies show that vitamin D deficiency may be associated with increased risk of chronic periodontitis [ 1 , 6 , 14 – 17 ], and that supplementation with vitamin D alone, or with vitamin D together with calcium may help to maintain periodontal health, may increase mineral density of the jaws, and may inhibit inflammatory alveolar bone resorption [ 15 , 18 – 21 ]. Furthermore, in subjects with adequate vitamin D, surgical treatment for chronic periodontitis appears to be more successful than in subjects with vitamin D deficiency [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D Deficiency as It Relates to Oral Immunity and Chronic Periodontitis

Khammissa

Ballyram

Jadwat

et al. 2018

International Journal of Dentistry

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The biologically active form of vitamin D, 1,25 dihydroxyvitamin D (1,25(OH)2D) and its receptor, the vitamin D receptor (VDR), play roles in maintaining oral immunity and the integrity of the periodontium. Results of observational cross-sectional clinical studies investigating the association between vitamin D serum level and the incidence and severity of chronic periodontitis indicate that, perhaps owing to the immunomodulatory, anti-inflammatory, and antibacterial properties of 1,25(OH)2 D/VDR signalling, a sufficient serum level of vitamin D is necessary for the maintenance of periodontal health. In cases of established chronic periodontitis, vitamin D supplementation is associated with reduction in the severity of periodontitis. As cross-sectional studies provide only weak evidence for any causal association and therefore are of questionable value, either longitudinal cohort studies, case controlled studies, or randomized control trials are needed to determine whether or not deficiency of vitamin D is a risk factor for chronic periodontitis, and whether or not vitamin D supplementation adjunctive to standard periodontal treatment is in any way beneficial. In this article, we discuss the relationship between vitamin D, oral immunity and periodontal disease and review the rationale for using vitamin D supplementation to help maintain periodontal health and as an adjunct to standard periodontal treatment.

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Section: Periodontitismentioning

confidence: 99%

Section: Periodontitismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Vitamin D Deficiency as It Relates to Oral Immunity and Chronic Periodontitis

Khammissa

Ballyram

Jadwat

et al. 2018

International Journal of Dentistry

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“…[ 21 ] Several recent reports demonstrate a significant association between periodontal health and the intake of Vitamin D. Evidence has demonstrated that Vitamin D might be beneficial for oral health, not only for its direct positive effect on bone health and mineral metabolism but also due to its indirect action as an anti-inflammatory agent. [ 22 23 24 ]…”

Section: Introductionmentioning

confidence: 99%

Correlation of vitamin D status and orthodontic-induced external apical root resorption

et al. 2017

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Background:Adequate Vitamin D is essential for dental and skeletal health in children and adult. The purpose of this study was to assess the correlation of serum Vitamin D level with external-induced apical root resorption (EARR) following fixed orthodontic treatment.Materials and Methods:In this cross-sectional study, the prevalence of Vitamin D deficiency (defined by25-hydroxyvitamin-D) was determined in 34 patients (23.5% male; age range 12–23 years; mean age 16.63 ± 2.84) treated with fixed orthodontic treatment. Root resorption of four maxillary incisors was measured using before and after periapical radiographs (136 measured teeth) by means of a design-to-purpose software to optimize data collection. Teeth with a maximum percentage of root resorption (%EARR) were indicated as representative root resorption for each patient. A multiple linear regression model and Pearson correlation coefficient were used to assess the association of Vitamin D status and observed EARR. P < 0.05 was considered statistically significant.Results:The Pearson coefficient between these two variables was determined about 0.15 (P = 0.38). Regression analysis revealed that Vitamin D status of the patients demonstrated no significant statistical correlation with EARR, after adjustment of confounding variables using linear regression model (P > 0.05).Conclusion:This study suggests that Vitamin D level is not among the clinical variables that are potential contributors for EARR. The prevalence of Vitamin D deficiency does not differ in patients with higher EARR. These data suggest the possibility that Vitamin D insufficiency may not contribute to the development of more apical root resorption although this remains to be confirmed by further longitudinal cohort studies.

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