Serum levels of YKL-40 increases in patients with acute myocardial infarction

Nøjgaard, Camilla; Høst, Nis; Christensen, Ib Jarle; Poulsen, Steen Hvitfeldt; Egstrup, Kenneth; Price, Paul A.; Johansen, Julia S.

doi:10.1097/mca.0b013e3282f40dd5

Cited by 88 publications

(67 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the same study, YKL-40 and UACR were independent markers of cardiovascular mortality with only weak intercorrelation and in accordance with the studies on low-grade albuminuria and risk of cardiovascular disease, YKL-40 and low-grade albuminuria synergistically predicted cardiovascular mortality. Other studies support this association between YKL-40 and cardiovascular morbidity and mortality, because YKL-40 levels are found to be associated with the presence and extent of coronary artery disease as assessed by coronary angiography (22), and, just recently, YKL-40 levels have been found to be elevated in patients with myocardial infarction (23).…”

Section: -Median Levels (Interquartile Range) Of Ykl-40 In the Three mentioning

confidence: 76%

YKL-40, a Marker of Inflammation and Endothelial Dysfunction, Is Elevated in Patients With Type 1 Diabetes and Increases With Levels of Albuminuria

et al. 2009

View full text Add to dashboard Cite

OBJECTIVE -The inflammation marker YKL-40 is elevated in patients with type 2 diabetes and is associated with atherosclerosis and increased cardiovascular mortality. In the present study, YKL-40 levels were examined in patients with type 1 diabetes with increasing levels of albuminuria, known to be associated with an increased risk of cardiovascular disease.RESEARCH DESIGN AND METHODS -A total of 149 patients with type 1 diabetes attending Steno Diabetes Center were examined: 58 had normoalbuminuria (urinary albumin excretion rate Ͻ30 mg/24 h), 46 had persistent microalbuminuria (urinary albumin excretion rate 30 -300 mg/24 h), and 45 had persistent macroalbuminuria/diabetic nephropathy (urinary albumin excretion rate Ͼ300 mg/24 h). The control group consisted of 55 healthy individuals. Groups were matched according to sex and duration of diabetes (Ͼ30 years).RESULTS -Median levels [interquartile range] of serum YKL-40 were significantly higher in normoalbuminuria versus control (37 [29 -52] vs. 53 [32-105] ng/ml, P Ͻ 0.01) and were increasing with increasing levels of albuminuria (microalbuminuria 74 [45-160] ng/ml and diabetic nephropathy 117 [68 -215] ng/ml; P Ͻ 0.001 for all comparisons). YKL-40 levels correlated with the urinary albumin-to-creatinine ratio in the total group of participants (r 2 ϭ 0.25, P Ͻ 0.001). Significant but weak intercorrelations of YKL-40 were found with age, diastolic blood pressure, A1C, and serum creatinine. After adjustment for significant covariates, albuminuria was significantly associated with YKL-40 levels (P Ͻ 0.001).CONCLUSIONS -YKL-40 levels are elevated in patients with type 1 diabetes with an independent association between increasing YKL-40 levels and increasing levels of albuminuria. The present study is the first to suggest a role of YKL-40 in the gradually progressing vascular complications in patients with type 1 diabetes.

show abstract

Section: -Median Levels (Interquartile Range) Of Ykl-40 In the Three mentioning

confidence: 76%

YKL-40, a Marker of Inflammation and Endothelial Dysfunction, Is Elevated in Patients With Type 1 Diabetes and Increases With Levels of Albuminuria

et al. 2009

View full text Add to dashboard Cite

show abstract

“…14,18,19 Recently, several clinical studies have described an association between increased YKL-40 levels, and several cardiovascular conditions, myocardial infarction, atrial fibrillation, and mortality. 10,20,21 PEX is a disorder of the extracellular matrix that is frequently related to severe chronic secondary open-angle glaucoma. 2 Extraocular deposition of pseudoexfoliation material has been localized to the connective tissues or septa traversing the organ tissue.…”

Section: Resultsmentioning

confidence: 99%

Serum YKL-40 levels as a novel marker of inflammation and endothelial dysfunction in patients with pseudoexfoliation syndrome

Türkyılmaz

Oner

Kırbaş

et al. 2013

Eye

View full text Add to dashboard Cite

Purpose To evaluate serum levels of YKL-40 in patients with pseudoexfoliation syndrome (PEX) in comparison with those of age-and sex-matched healthy subjects. Methods Forty patients with PEX (PEX group) and 40 age-and sex-matched control subjects (control group) were enrolled in the study. An enzyme immunoassay method using the commercially available test MicroVue YKL-40 was used to measure serum YKL-40 concentration. Systolic and diastolic blood pressures, serum levels of high sensitivity C-reactive protein (hsCRP), total cholesterol, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglycerides were also examined. Results The mean age was 54.4 ± 7.6 (ranging 41-65) years in each group. The mean serum YKL-40 level of the PEX group was significantly higher than that of the control group (Po0.001). In addition, the mean serum HsCRP, total cholesterol, LDL, and triglycerides levels were significantly higher, and mean serum HDL level was significantly lower in the PEX group than in the control group (all Po0.001, excluding both P ¼ 0.002 for triglycerides and HDL levels). Further, the mean systolic and diastolic blood pressures were significantly higher in the PEX group than in the control group (P 1 ¼ 0.001 and P 2 ¼ 0.01, respectively). Conclusion We have shown a relationship between PEX and elevated serum levels of YKL-40. We imply that a better understanding of the role of YKL-40 in the pathogenesis of endothelial dysfunction and atherosclerosis is necessary to develop new therapies for preventing or treating PEX. Further studies are warranted to clarify the clinical relevance of these findings.

show abstract

“…High in vivo expression of YKL-40 mRNA and protein is found by macrophages in tissues with inflammation such as arteriosclerotic plaques [15], inflamed synovial membranes [16], arthritic vessels of patients with giant cell arteritis [17], and peritumoral macrophages [18]. Plasma YKL-40 is significantly increased in patients with ST-elevation myocardial infarction (STEMI) and stable chronic coronary artery disease (CAD) [19][20][21]. Patients with persistent AF have higher plasma levels of YKL-40 than patients with SR, but significantly lower levels than patients with permanent AF [22].…”

Section: Introductionmentioning

confidence: 99%

Plasma YKL-40 is elevated in patients with recurrent atrial fibrillation after catheter ablation

et al. 2009

Self Cite

View full text Add to dashboard Cite

show abstract

Serum levels of YKL-40 increases in patients with acute myocardial infarction

Abstract: These results demonstrated that serum concentrations of YKL-40 are greatly increased in AMI patients with and without thrombolytic therapy.

Cited by 88 publications

References 57 publications

YKL-40, a Marker of Inflammation and Endothelial Dysfunction, Is Elevated in Patients With Type 1 Diabetes and Increases With Levels of Albuminuria

YKL-40, a Marker of Inflammation and Endothelial Dysfunction, Is Elevated in Patients With Type 1 Diabetes and Increases With Levels of Albuminuria

Serum YKL-40 levels as a novel marker of inflammation and endothelial dysfunction in patients with pseudoexfoliation syndrome

Plasma YKL-40 is elevated in patients with recurrent atrial fibrillation after catheter ablation

Contact Info

Product

Resources

About