Serum Lipid Abnormalities and Nonalcoholic Fatty Liver Disease in Adult Males

Peng, Keping; Mo, Zengnan; Tian, Guixiang

doi:10.1016/j.amjms.2017.01.002

Cited by 45 publications

(28 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Atherogenic dyslipidemia, characterized by plasma hypertriglyceridemia, increased small dense LDL particles, and decreased HDL-C levels, is variably present in patients with NAFLD [ [49] , [50] , [51] , [52] ]. The liver plays a central role in lipoprotein metabolism as it participates in the production and/or clearance of all classes of lipoprotein particles.…”

Section: Dyslipidemia: Linking Hepatic Lipid Metabolism and The Heartmentioning

confidence: 99%

See 1 more Smart Citation

Dysregulated lipid metabolism links NAFLD to cardiovascular disease

Deprince

Haas

Staels

2020

Molecular Metabolism

314

161

View full text Add to dashboard Cite

Background Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a global health problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD patients. NAFLD and CVD share several common risk factors including obesity, insulin resistance, and type 2 diabetes (T2D). Atherogenic dyslipidemia, characterized by plasma hypertriglyceridemia, increased small dense low-density lipoprotein (LDL) particles, and decreased high-density lipoprotein cholesterol (HDL-C) levels, is often observed in NAFLD patients. Scope of review In this review, we highlight recent epidemiological studies evaluating the link between NAFLD and CVD risk. We further focus on recent mechanistic insights into the links between NAFLD and altered lipoprotein metabolism. We also discuss current therapeutic strategies for NAFLD and their potential impact on NAFLD-associated CVD risk. Major conclusions Alterations in hepatic lipid and lipoprotein metabolism are major contributing factors to the increased CVD risk in NAFLD patients, and many promising NASH therapies in development also improve dyslipidemia in clinical trials.

show abstract

Section: Dyslipidemia: Linking Hepatic Lipid Metabolism and The Heartmentioning

confidence: 99%

“…NAFLD patients often display hypertriglyceridemia [ [49] , [50] , [51] , [52] ] and elevated remnant lipoprotein particle concentrations, which are indicative of delayed intravascular TG metabolism [ 63 ]. Both features increase cardiovascular risk.…”

Section: Dyslipidemia: Linking Hepatic Lipid Metabolism and The Heartmentioning

confidence: 99%

Dysregulated lipid metabolism links NAFLD to cardiovascular disease

Deprince

Haas

Staels

2020

Molecular Metabolism

314

161

View full text Add to dashboard Cite

show abstract

“…This was an important finding in our opinion. This is because NAFLD is characterized by atherogenic dyslipidemia, postprandial lipemia and high-density lipoprotein (HDL) dysfunction which are established risk factors for both cardiovascular and liver disease [47,48]. A possible mechanistic explanation for the observed antidyslipidemic affects is the AMP kinase inhibition described previously.…”

Section: Discussionmentioning

confidence: 97%

Hepatoprotective effects ofErythrina abyssinicaLam Ex Dc against Non Alcoholic Fatty Liver Disease in Sprague Dawley Rats

Yenesew

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Non-alcoholic fatty liver disease (NFLD) is the hepatic manifestation of the metabolic syndrome recognized as the most prevalent chronic liver disease across all age groups. NFLD is strongly associated with obesity, insulin resistance, hypertension and dyslipidemia. Extensive research efforts are geared, through pharmacological approach, towards preventing or reversing this. Erythrina abyssinica Lam ex DC is an indigenous tree used widely used in traditional medicine, including for the treatment of liver related diseases, and has been shown to possess hypoglycemic, anti-oxidant, antimicrobial and anti-plasmodia effects. The present study is aimed at establishing the effects of E. abyssinica on the development of Non-alcoholic fatty liver disease induced by a high-fat and high-sugar diet in rats, in-vivo model. (40) were randomly divided into five groups: positive control (pioglitazone), Negative control (high fat/high sugar diet), low test dose (200 mg/kg), high test dose (400 mg/kg) and normal group (standard chow pellets and fresh water). Methods: Forty ratsThe inhibitory effect of the stem bark extract of E. abyssinica on the development of NAFLD was evaluated by chronic administration the herb extracts to rats on a high-fat/high-sugar diet.Biochemical indices of hepatic function including serum lipid profile, serum aspartate transaminase and alanine transaminase levels were then determined. Histological analysis of liver samples was carried out to quantify the degree of steato-hepatitis. Liver weights were taken and used to determine the hepatic index. The data was analyzed using one-way ANOVA, and Tukey's post-hoc tests were done in cases of significance. Histology data was analyzed using Kruskal-Wallis and Dunn's post-hoc test was done in cases of significance. Significance was set at p<0.05. Results:The freeze dried extract of E. abyssinica had significant effects on fasting blood glucose [5.43 ± 0.17 (HF/HSD) vs 3.8 ± 0.15 (E 400 mg/kg) vs 4.54 ± 0.09 (E 200 mg/kg) vs. 4.16 ± 0.13 (PIOG) vs. 2.91 ± 0.16 (normal control): P value < 0.0001], and insulin sensitivity [329.4 ± 13.48 mmol/L · min (HF/HSD) vs. 189.8 ± 12.11 mmol/L · min (E 400 mg/kg) vs. 233.8 ± 6.55 mmol/L · min (E 200 mg/kg) vs. 211.1 ± 7.35 mmol/L · min (PIOG) vs. 142.9 ± 11.94 mmol/L · min: P value < 0.0001],The extract had significant effects on hepatic indices including, hepatic triglycerides (P value < 0.0001), liver weights (P value < 0.0001), liver weight-body weight ratio (P value < 0.0001), serum ALT levels (P value < 0.0001), serum AST (P value < 0.0017), serum total cholesterol (P value < 0.0001), serum triglycerides (P value < 0.0001), and serum LDL-cholesterol (P value < 0.0001). The extracts however showed no significant effects on HDL-cholesterol (P value = 0.4759).Histological analysis showed that the extract appears to possess protective effects against steatosis, inflammation and hepatic ballooning, with the high dose (400mg/kg) being more hepatoprotective. Conclusion:The freeze dried stem bark extract of Eryth...

show abstract

“…In addition to the mechanisms mentioned above, the expression of genes involved in lipid metabolism is regulated by affecting the methylation modification of adipose DNA to reduce the content of TG and TC, and thus liver damage caused by NAFLD is effectively alleviated [30]. Recent research has indicated that compared with non-NAFLD population, the levels of TC in NAFLD patients increase evidently [31,32]. Moreover, as NAFLD aggravated, the content of TC is evidently increased [33].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of miR-499-5p expression improves nonalcoholic fatty liver disease

Liu

Wang

Chen

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Nonalcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver diseases. However, the pathogenesis of NAFLD is largely unknown. Here, we investigated the specific role of miR-499-5p in NAFLD. Method: Free fatty acid (FFA) was used to induce HL-7702 cell line to establish a NAFLD cell model, and animal models of NAFLD were constructed by feeding C57BL/6 mice with high fat diet (HFD). Expression levels of miR-499-5p in the HL-7702 cells and C57BL/6 mice were determined by RT-qPCR. In addition, functional experiments were carried out through transfecting miR-499-5p inhibitor into NAFLD cells, and injecting NAFLD mice with a lentiviral vector with knock down the miR-499-5p . Furthermore, the effects of miR-499-5p inhibition on lipidation and inflammation were investigated by oil red O staining, HE staining, and biochemical analysis. Results: Compared with normal controls, the expression of miR-499-5p was significantly up-regulated in NAFLD cells and tissues in mouse (P < 0.05). After NAFLD cells transfected by miR-499-5p inhibitor, the expression of miR-499-5p was inhibited, the lipid deposition and content of TG were reduced, and the lipidation was improved (P < 0.05). Simultaneously, after NAFLD mice were injected with knocked down the miR-499-5p lentiviral vector, the degree of lipid droplet deposition and content of TG were also reduced. Besides, it also decreased the levels of TC and AST in serum, and improved hepatic lipid metabolism (P < 0.05). Conclusion: Inhibition of miR-499-5p expression improved NAFLD in mice, which provided a new direction for the treatment of NAFLD.

show abstract

Serum Lipid Abnormalities and Nonalcoholic Fatty Liver Disease in Adult Males

Cited by 45 publications

References 21 publications

Dysregulated lipid metabolism links NAFLD to cardiovascular disease

Dysregulated lipid metabolism links NAFLD to cardiovascular disease

Hepatoprotective effects ofErythrina abyssinicaLam Ex Dc against Non Alcoholic Fatty Liver Disease in Sprague Dawley Rats

Inhibition of miR-499-5p expression improves nonalcoholic fatty liver disease

Contact Info

Product

Resources

About