Serum lipid and lipoprotein profile in children with iron deficiency anemia

Ece, Aydın; Yigitoglulu, M Ramazan; Vurgun, Nureddin; Güven, Hasan; İşcan, Akın

doi:10.1046/j.1442-200x.1999.4121036.x

Cited by 8 publications

(10 citation statements)

References 14 publications

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“…A number of studies have suggested links between Fe deficiency anemia and altered lipid metabolism; however, these studies do not all find the same effects. For example, children with Fe deficiency anemia have either increased plasma cholesterol concentrations (44) or reduced plasma cholesterol concentrations (8). In animal studies, maternal dietary Fe restriction during gestation either increases plasma lipid concentrations in the offspring (40) or has no effect on plasma cholesterol concentrations in the adult offspring (29).…”

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Maternal dietary iron restriction modulates hepatic lipid metabolism in the fetuses

Zhang¹,

Lewis²,

Wang³

et al. 2005

American Journal of Physiology-Regulatory, Integrative and Comp

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(TG) concentrations in the fetuses, as well as decreased plasma TG levels in the adult offspring. To investigate how maternal Fe restriction was affecting fetal lipid metabolism, we investigated whether there were changes in liver lipid metabolism in the full-term fetuses. There was a ϳ27% (P Ͻ 0.05) increase in cholesterol but ϳ29% reduction (P ϭ 0.01) in TG concentrations in the liver of the Fe-restricted fetuses. Hepatic mRNA levels of cholesterol 7␣ hydroxylase and liver X receptor-␣ (LXR␣) were reduced by ϳ50% (P Ͻ 0.01) and ϳ34% (P Ͻ 0.01), respectively. As LXR␣ regulates expression of sterol response element binding protein-1c (SREBP-1c) expression, we measured SREBP-1c expression. There was an ϳ43% (P Ͻ 0.001) reduction in mRNA levels of SREBP-1c and its response genes, including acetyl-CoA carboxylase by ϳ35% (P ϭ 0.01), fatty acid synthase by ϳ18% (P ϭ 0.05), and diacylglycerol acyltransferase by ϳ19% (P ϭ 0.03). Furthermore, protein levels of CD36 were reduced by ϳ27% (P ϭ 0.02) in Fe-restricted fetuses. In conclusion, changes in liver cholesterol and TG concentrations in Fe-restricted fetuses may be coordinated through reduced expression of heme-containing cholesterol 7␣ hydroxylase and its regulator LXR␣, mainly via downregulation of expression of genes in bile acid synthesis and fatty acid synthesis pathways. cholesterol; cholesterol 7 alpha hydroxylase; liver X receptor-alpha; fetus ABNORMALITIES IN LIPID METABOLISM are associated with the metabolic syndrome, Type 2 diabetes and coronary heart disease (45). Plasma lipid profile may be affected by a change in development before birth, which has been referred to as the "fetal origins," "thrifty phenotype," or "fetal programming" hypothesis (3,16,17,30). This hypothesis is supported by data from epidemiological and animal studies. For example, people who had a small abdominal circumference at birth had raised serum concentrations of total cholesterol and low-density lipoprotein-cholesterol and apolipoprotein B in adulthood (2). People exposed to famine in early gestation had a more atherogenic lipid profile than did those who were not exposed to famine in utero (38). In animal studies, maternal dietary protein restriction during either (both) gestation or (and) lactation reduces total cholesterol and high-density lipoproteincholesterol in the rat offspring (31). Increased dietary cholesterol intake in the mother during gestation increases long-term progression of atherosclerosis in the rabbit offspring (33), and treatment of the mother with vitamin E or cholestyramine during gestation markedly reduces the progression of atherogenic lesions in the aorta of these offspring (33). In the rat, maternal calorie restriction causes hyperphagia, obesity, and hypertension in the rat offspring (48), and maternal dietary Fe restriction reduces offspring plasma triglyceride (TG) concentrations (29). Thus these data suggest that a change in maternal physiology may have a long-lasting effect on lipid metabolism in the offspring.Fe deficiency is a common nutritio...

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Maternal dietary iron restriction modulates hepatic lipid metabolism in the fetuses

Zhang¹,

Lewis²,

Wang³

et al. 2005

American Journal of Physiology-Regulatory, Integrative and Comp

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“…However a study on ID Korean girls (14-19 years) found reduced levels of TG in severe IDA while another study 9 on Turkish children with IDA found no effect on either TG or VLDL levels.…”

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“…However, Ece et al 9 in a study on IDA children reported reduced LDL levels, which returned to control levels after the iron therapy. Serum TC did not show any significant alteration in the IDA group while previous studies have reported variable results in relation to TC, with some studies reporting it as normal, 10,20 while others reporting low levels.…”

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confidence: 91%

“…3,5 Various studies, both in animals 6,7 and in humans 8,9 have linked IDA with altered blood lipid profile. Lewis and Iammarino 10 reported increased triglycerides (TG) and chylomicron levels in male Sprague-Dawley rats, made iron deficiency by dietary iron lack.…”

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confidence: 99%

“…Serum TC did not show any significant alteration in the IDA group while previous studies have reported variable results in relation to TC, with some studies reporting it as normal, 10,20 while others reporting low levels. 8,9 Various studies have been performed to define the related mechanisms underlying dyslipidemias in IDA. High TG levels have been explained on the basis of impaired carnitine biosynthesis together with increased T G synthesis and decreased TG degradation 8,10,21 in IDA while lower serum cholesterol has been related to be due to decreased hepatic synthesis 6 or dilutional effects of serum.…”

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confidence: 99%

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A study of correlation between iron deficiency anaemia and serum lipid profile in Indian adults in BRIMS, Bidar

Antappanavar¹,

Biradar²,

Patil³

et al. 2014

Int J Adv Med

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Late-life Cardiac Injury in Rats following Early Life Exposure to Lead: Reversal Effect of Nutrient Metal Mixture

Davuljigari

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2019

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Serum lipid and lipoprotein profile in children with iron deficiency anemia

Abstract: Patients with IDA are also deficient in macronutrients. The low atherogenic serum lipid profile of IDA is not a direct result of iron deficiency itself, but related to decreased energy and protein intakes.

Cited by 8 publications

References 14 publications

Maternal dietary iron restriction modulates hepatic lipid metabolism in the fetuses

Maternal dietary iron restriction modulates hepatic lipid metabolism in the fetuses

A study of correlation between iron deficiency anaemia and serum lipid profile in Indian adults in BRIMS, Bidar

Late-life Cardiac Injury in Rats following Early Life Exposure to Lead: Reversal Effect of Nutrient Metal Mixture

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