Serum lipid levels and suicidality among male patients with schizoaffective disorder

Cholesterol in coronary heart disease and psychiatric disorders: Same or opposite effects on morbidity risk?

“…Since in a multivariate analysis, self-harm was significantly correlated with levels of omega-3 fatty acids but not cholesterol levels, the authors concluded that cholesterol was acting as a marker or ''bystander'' for levels of omega-3 fatty acids and was not the primary underlying cause of self-harm among patients. Marčinko et al (2008) measured serum concentrations of TC, LDL-C, and HDL-C in 40 men with schizoaffective disorder and 20 matched controls. Based on the presence of suicide attempts, the clinical group was divided into two subgroups each including 20 participants.…”

Serum triglycerides, but not cholesterol or leptin, are decreased in suicide attempters with mood disorders

“…Many studies have searched for and proposed biological markers that might be linked to suicidal behavior and could be used as an additional tool for prevention and therapeutic actions (Arango et al, 2003;Asellus et al, 2010;De Luca et al, 2005;Lee and Kim, 2011;Marcinko et al, 2008;Pandey, 2013). Many peripheral markers have been investigated in persons vulnerable to suicide, including low serum cholesterol and its fractions (Atmaca et al, 2002;Chang et al, 2012;Coryell and Schlesser, 2007;Jee et al, 2011;Jokinen et al, 2010;Lee and Kim, 2003;Olie et al, 2011;Papadopoulou et al, 2013;Troisi, 2009).…”

Potential neurochemical links between cholesterol and suicidal behavior

“…Vuksan-Cusa et al, 2009) and cohort studies (e.g Boscarino et al, 2009). Among the few studies that differentiate the fractions of cholesterol, suicidal behavior and impulsivity have been associated with lower levels of low-density lipoprotein/cholesterol (Lee and Kim, 2003;Agargun et al, 2004;Garland et al, 2007;Marcinko et al, 2008), while low levels of high-density lipoprotein/cholesterol have been more strongly associated with depressive symptomatology (Troisi, 2009). The earliest mention of suicide in a clinical study designed to assess the influence of diet on cardiovascular disease risk probably occurred in the 1960s (Dayton and Pearce, 1969).…”

“…Case-control studies developed in clinical populations have often shown that individuals with past suicide attempts had lower levels of serum cholesterol, compared to patients without the same history (Guillem et al, 2002;Kim et al, 2002;Atmaca et al, 2003;Lee and Kim, 2003;Favaro et al, 2004;Kim and Myint, 2004;Fiedorowicz and Coryell, 2007;Marcinko et al, 2008); again the findings are not unanimous, with negative results regarding this association reported (Apter et al, 1999;Almeida-Montes et al, 2000;Huang and Wu, 2000;Roy et al, 2001;Deisenhammer et al, 2004;Huang, 2005;De Leon et al, 2011. It is important to mention, at this time, that the low cholesterol referred to throughout this text does not necessarily constitute hypocholesterolemia, which is defined as total cholesterol and low density protein/ cholesterol levels of below the 5th percentile of the general population, when adjusted for age, gender and race (Moutzouri et al, 2011).…”