Serum lipid levels and the prevalence of hyperlipidaemia in malaysia

Chong, Y.H.; Khoo, K.L.

doi:10.1016/0009-8981(75)90346-0

Cited by 4 publications

(4 citation statements)

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“…These observations are consistent with the findings on the association of TC values with age in other studies. 10,17 Interestingly, TC values in females were markedly higher than in the males for each age category. This trend was apparent in all the age groups studied, and was consistent with a similar observation among 3600 subjects drawn from 14 rural ‘poverty kampungs’ in the states of Kelantan, Johore, Kedah and Perak during 1979–83.…”

Section: Resultsmentioning

confidence: 92%

“…As TC increases with age, it is clear that the risk classification used for adults is not appropriate for children and adolescents, an issue which has been raised previously. 10 Using the data in Table 2 and applying the same rationale as used for adults, it is recommended that the TC cut‐off value for ‘increased risk’ in children and adolescents be 5.17 mmol/L, which approximates the combined TC mean + 1SD for these age groups (children + adolescents).…”

Section: Resultsmentioning

confidence: 99%

“…Previous reports on TC values in Malaysian populations have been provided mainly by Chong and Khoo, 10 Chong, et al , 11 and Khoo et al 12 The early data of Chong and Khoo 10 was essentially ‘urban’, as was the data of Khoo et al 12 Chong et al ’s study, 11 conducted by the Institute for Medical Research (IMR) during 1979–83 in four states in the peninsula, represented rural data. However, the number of subjects measured for TC was small, as venipuncture was used in blood collection.…”

Section: Introductionmentioning

confidence: 99%

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Nutritional assessment of rural villages and estates in peninsular Malaysia: Total blood cholesterol values in children, adolescents and adults*

Wai

Lin

Siong

et al. 2000

Asia Pac J Clin Nutr

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The present study is unique in the Malaysian context on two counts; first, it employs for the first time a functional group approach (groups based on occupational or economic activity) in the assessment of community nutritional status. Second, the study provides on a nationwide-sampling basis, information on total blood cholesterol (TC) levels in rural children (7.0-12.9 years; n = 1921) and adolescents (13.0-17.9 years; n = 753) which were hitherto unavailable. Total blood cholesterol measurements were performed on 7184 subjects ranging from 7 to 75-years-old (males = 3151; females = 4033) from households in 69 rural villages and seven estates in peninsular Malaysia, which were based on selected multistage random sampling according to the household's involvement in the following economic activities: rice farming, rubber smallholding, coconut smallholding, fishing and employment in estates. In all functional groups, TC values increased with age and there was a distinct gender effect, namely females had higher TC values than males throughout the age spectrum analyzed. Mean TC levels for children and adolescents were in the range 3.85-4.37 mmol/L, rising markedly during adulthood to an overall mean of 4.91 ± 1.13 mmol/L for men and 5.17 ± 1.11 mmol/L for women. In adults (>= 18.0 years), there was marked disparity in mean TC values among the functional groups; males and females from rice households had the lowest mean TC values (4.58 and 4.99 mmol/L, respectively). Individuals at 'high risk' (TC > 6.20 mmol/L) averaged 16.0% in women and 11.6% in men, with women from the fishing, rubber and coconut households particularly affected (17.1-21.1%). When compared to earlier rural TC data reported for closely similar rural communities in the peninsula, the present findings suggest a 'hypercholesterolemic shift' approximating 0.39 mmol/L (15 mg/dL) in the adult population; however, this was not apparent in the children and adolescents from these rural communities.

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nutritional assessment of rural villages and estates in peninsular Malaysia: Total blood cholesterol values in children, adolescents and adults*

Wai

Lin

Siong

et al. 2000

Asia Pac J Clin Nutr

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“…12 Accordingly, it might be suggested that a high level of physical activity would prevent an agerelated increase of the plasma lipids. Whether lifelong physical activity of moderate intensity, in man, may reduce the increase of plasma lipids occurring with age 13 " 16 is not known. It appears, however, that a high level of spontaneous physical activity in rats does not prevent an age-related increase in plasma cholesterol and triglyceride concentration.…”

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confidence: 99%

Age-related changes in the concentration of plasma cholesterol and triglycerides in two groups of rats with inherited widely different levels of spontaneous physical activity.

Rasmussen¹,

Hłstmark²

1978

Circulation Research

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SUMMARY The plasma concentration of cholesterol and triglycerides was determined in two groups of rats with inherited widely different levels of spontaneous physical activity. Active as well as passive rats of each sex were divided into two subgroups, one with free access to wheel running activity {exercising group), and another for which admittance to the drum was closed (nonexercising group). Plasma concentrations of cholesterol and triglycerides were followed from the age of 3-8 months in females and 3 months to 1 year in males. A pronounced increase with age in the plasma concentration of these lipids was observed in the active male rats. In the passive male rats and in all females, there were no major changes in plasma levels of cholesterol and triglycerides. Corresponding groups of exercising and nonexercising rats had similar plasma levels of these components. The data for male rats show a positive association between the inherited tendency to perform spontaneously a high level of physical activity and an age-related increase in plasma lipids. However, running activity per se does not seem to have any influence on the level of plasma cholesterol and triglycerides in these rats.REPORTS ON the chronic effects of physical activity on plasma lipid concentration are conflicting. In man, Lopez-S et al.1 observed a minimal decrease in plasma cholesterol level following long-term physical training. Also Wood et al.2 reported a somewhat lower plasma cholesterol concentration in physically active men, 35-39 years of age, compared to that found in a control group of relatively inactive men. However, physically active men above this age did not have a significantly lower plasma cholesterol concentration than inactive controls. In the rat, Papadopoulos et al. 3 observed that plasma cholesterol decreased in response to exercise; however, others found no such effect. "7 Even an increased concentration of cholesterol in response to long-term exercise was observed by Herbert et al. 8 in old rats maintained on a high sucrose diet. A lowering effect of long-term physical activity on plasma triglyceride concentration appears to be a more consistent finding. It has been demonstrated in this laboratory, through selective breeding, that the level of spontaneous physical activity in rats is inheritable. In offspring of active parents, the level of spontaneous wheel-running activity is severalfold higher than that observed in offspring of passive parents. In an attempt to elucidate the effect of voluntary physical activity on the level of plasma lipids, we have determined the concentration of cholesterol and triglycer- Received July 7, 1977; accepted for publication December 13, 1977. ides in the plasma of two groups of selected female and male rats with widely differing levels of spontaneous wheel-running activity. The plasma lipid concentration was followed from the age of 3-8 months in females and from 3 months to 1 year in males, i.e., for about one-third to one-half of their normal life-span. The rats were kept individu...

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