Serum lipid levels correlate to the progression of gastric cancer with neuroendocrine immunophenotypes: A multicenter retrospective study

Zou, Yi; Wu, Long; Yang, Yubin; Ding, Zonghui; Huang, Jiaming; Li, Peng; Zhu, Chunpeng; Yuan, Ying

doi:10.1016/j.tranon.2020.100925

Cited by 9 publications

(8 citation statements)

References 21 publications

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“…Contrary to previous study [22,23], serum lipid level was not an independent prognostic predictor of survival outcome in PanNENs. There were multiple reasons that lead to this conclusion.…”

Section: Discussioncontrasting

confidence: 99%

“…Multicenter research has discovered that obviously lower HDL and TC existed in the gastric cancer with neuroendocrine immunophenotypes group in comparison to normal population. Higher TG and HDL may reduce overall risk of developing gastric cancer with neuroendocrine carcinoma [22]. In digestive NENs, the survival rate of patients with high LDL levels was 4.738 times higher than that of patients with low LDL levels (95% CI:1.424-15.772, P = 0.019), but there is not evidently relevance on survival time [23].…”

Section: Discussionmentioning

confidence: 94%

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The characteristics of serum lipid spectrum in PanNENs and its correlation with clinicopathological features and prognosis

Zhan

Meng

Fan

et al. 2022

Preprint

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Background： The role of dyslipidemia in pancreatic neuroendocrine tumors (PanNENs) is unclear. The aim of this study is to analyze the characteristics of serum lipid spectrum in PanNENs, and the effect of the variation in lipid profile on the development of PanNENs clinicopathological features and prognosis. Methods All PanNENs patients between November 2012 and September 2020 in the authors' research center were identified from patient medical records and database. Clinicopathologic features, serum lipid level and overall survival results were retrospectively analyzed using statistical methods. Results： This retrospective cohort study displays that insulinoma patients exhibits increased serum HDL level compared to non-functional PanNENs (OR:2.522; 95% CI:1.096-5.803; P = 0.030). High levels HDL were negatively correlated with tumor diameter (OR 0.233; 95% CI: 0.069-0.790; P=0.019). However, there was no significant difference between PanNENs patients with hyperlipidemia and normal blood lipid level in tumor location, tumor diameter, pathological grade, and clinical stage. In the univariate and multivariate analyses, there is also no significant correlation between hyperlipidemia and overall survival. Conclusions： HDL was negatively correlated with the tumor size of PanNENs. Although the serum HDL level of insulinoma patients is higher than nonfunctional PanNENs, dyslipidemia may not be an independent predictor of survival outcome.

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“…Contrary to previous study [22,23], serum lipid level was not an independent prognostic predictor of survival outcome in PanNENs. There were multiple reasons that lead to this conclusion.…”

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 94%

The characteristics of serum lipid spectrum in PanNENs and its correlation with clinicopathological features and prognosis

Zhan

Meng

Fan

et al. 2022

Preprint

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“…Two studies showed that a population exposed to a higher level of total cholesterol (TC) would signi cantly increase the risk of GC incidence (Lim et al 2022; Kitahara et al 2011). Following evidence con rmed these preceding ndings and further found elevated low-density lipoprotein cholesterol (LDL-C) (Pih et al 2021;Zou et al 2021) and triglyceride (TG) (Li et al 2018) may also increase the incidence risk of GC. Furthermore, high-density lipoprotein cholesterol (HDL-C) was traditionally believed to be a protective factor for cardiovascular diseases, whereafter several prospective studies have shown that lower HDL-C would also increase the risk of GC (Li et al 2018;Lim et al 2022;Nam et al 2019).…”

Section: Introductionmentioning

confidence: 84%

Associations of serum lipid level with risk of gastric cancer: A longitudinal study over 8 years

Stankovic

et al. 2022

Preprint

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Purpose The association of lipid metabolism linked the risk of gastric cancer (GC) was widely debated. We aimed to explore the longitudinal associations between total cholesterol, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) with the incident risk of GC. Methods The serum lipids were quarterly stratified based on the distribution of GC-free populations. The Cox proportional hazard models and restricted cubic spline models were applied to estimate the hazard ratios (HRs) and dose-response association of GC under different sub-analyses. The interactions of serum lipids on GC incidence were tested by generalized additive models. Results After average 7.2±1.2 years follow-up, 248 primary GCincident cases were collected among 45,642 cancer-free baseline individuals.In total population, the hazard risks (HRs) with 95% confidence interval (CI) of TG (HR=1.53, 95% CI: 1.02-2.29) and LDL-C (HR=2.21, 95% CI: 1.51-3.24) were significantly increased when the Q4 stratum compared with Q1. While decreased HR was found in the Q4 stratum of HDL-C (HR=0.42, 95% CI: 0.26-0.67). Further sub-analyses testified these associations in males solely. The highest GC incident risk was plainly visible when both HDL-C and LDL-C were abnormal (HR=5.38, 95% CI: 3.43-8.45), followed by excess TG and hypo-HDL-C group (HR=2.75, 95% CI: 1.89-4.00) and excess TG and LDL-C group (HR=2.55, 95% CI: 1.78- 3.64) compared with normal lipid group. Conclusion Lipid metabolism abnormalities could be important risk factors for GC. Additionally, a combination of any abnormalities among TG, HDL-C, and LDL-C would interactively elevate the incidence risk of GC.

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“…According to the data on preoperative HDL-C or LDL-C levels, patients were divided into HDL-low (< 1.15 mmol/L) and HDL-normal (≥ 1.15 mmol/L and < 1.68 mmol/L) groups (due to the low proportion of GC with elevated HDL-C [ 27 ], those patients were not included in this study) or LDL-low (< 2.10 mmol/L), LDL-normal (≥ 2.10 mmol/L and < 3.10 mmol/L) and LDL-high (≥ 3.10 mmol/L) groups.…”

Section: Methodsmentioning

confidence: 99%

Adverse effects of low serum lipoprotein cholesterol on the immune microenvironment in gastric cancer: a case‒control study

Zou

Zhou

et al. 2022

Lipids Health Dis

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Background Cholesterol is crucial for tumor immune microenvironment (TIME) remodeling. Serum lipoprotein cholesterol is closely associated with gastric cancer (GC) progression, but whether it affects TIME remodeling is unknown. Methods GC patients with differential serum high-density lipoprotein (HDL) or low-density lipoprotein (LDL) cholesterol levels were collected. After balancing the baseline, immunohistochemical staining was performed on serial whole-tissue sections to detect B-cell and T-cell subsets, macrophages, and PD-L1. Features of tertiary lymphoid structures (TLSs) and the extra-TLS zone, including TLS distribution and maturation, immune cell density, and PD-L1 expression, were measured by annotating TLSs or regions of interest (ROIs) in the extra-TLS zone. Results A total of 9,192 TLSs and over 300 ROIs from 61 patients were measured. Compared to HDL-normal patients, HDL-low patients had a decreased secondary-TLS fraction or density but an elevated NK-cell density in the extra-TLS zone. Compared to LDL-normal patients, LDL-low patients had a higher ratio of PD-1 + T follicular helper cells to CD20 + B cells in TLSs, a higher ratio of PD-1 + T cells to CD8 + T cells and increased PD-1 + T-cell density in the extra-TLS zone. Different correlations were found in groups with differential HDL or LDL levels. Cell dynamics in the immune response were weaker in patients with low lipoprotein cholesterol. TLS parameters reached their peak earlier than those of the extra-TLS zone along with tumor progression. Conclusion Low serum lipoprotein cholesterol caused adverse effects on antitumor immunity in GC. Lipid management or immunometabolic drugs deserve more attention.

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Serum lipid levels correlate to the progression of gastric cancer with neuroendocrine immunophenotypes: A multicenter retrospective study

Abstract: Highlights The serum lipid patterns of GCNEI differed from those of pure gastric adenocarcinoma significantly. Serum lipid levels correlated to the progression of GCNEI. Serum lipid levels impacted the risk of the occurrence of GCNEI.

Cited by 9 publications

References 21 publications

The characteristics of serum lipid spectrum in PanNENs and its correlation with clinicopathological features and prognosis

The characteristics of serum lipid spectrum in PanNENs and its correlation with clinicopathological features and prognosis

Associations of serum lipid level with risk of gastric cancer: A longitudinal study over 8 years

Adverse effects of low serum lipoprotein cholesterol on the immune microenvironment in gastric cancer: a case‒control study

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