Serum lipid levels in iron deficiency anemia and effects of various treatments.

Studies were carried out to determine the effect of additive iron-glycine chelate on the production performance, slaughter yield, mineral deposition in the liver and the metabolic blood panel in broiler chickens. A total of 250 one-day-old Ross 308 chicks were allotted into five groups with five replicates of 10 birds each. Diets were supplemented with the organic form iron (Fe-Gly at the rate of 25%, 50% or 100% of the total requirements of the elements) and inorganic Fe (FeSO4 at the rate of 50% or 100%). In the experiment, iron was added to the premix (containing no Fe) in an amount of 40 or 20 mg per kg of basal diet, in groups I and II, in the form of FeSO4 , and in an amount of 40, 20 or 10 mg per kg of basal diet, in groups III, IV and V, in the form of Fe-Gly. The study covering the period from the first to the 42nd day of breeding revealed that the production performance and slaughter yield were not dependent on the form and amount of added Fe. In the experimental groups with the addition of Fe-Gly of 20 or 10 mg/kg, there were no deaths of chickens during the whole fattening period. As a result, introducing an organic form of iron covering 50% and 25% of the birds' requirement increased the effectiveness of chicken fattening (European Efficiency Index) (p < 0.01). An organic Fe compound (40, 20 or 10 mg/kg) added to mixtures contributed to significant changes in the level of biochemical and haematological indicators in blood. The study demonstrated that an addition of Fe-Gly to mixtures for broilers can be fully effective in terms of production and health performance even if the suggested requirement for this element is 50% or 25% covered.

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“…The findings of Ohira et al. () and Cunnane and McAdoo () were similar. On the other hand, Guthrie et al.…”

Section: Discussionsupporting

confidence: 65%

“…Bristow-Craig et al (1994) demonstrated that higher levels of iron in a diet increased cholesterol in the plasma of rats. The findings of Ohira et al (1980) and Cunnane and McAdoo (1987) were similar. On the other hand, Guthrie et al (1974) and Amine et al (1976) observed hyperlipidemia in rats and chickens fed on diets deficient in iron.…”

Section: Discussionsupporting

confidence: 53%

Effects of iron–glycine chelate on growth, carcass characteristic, liver mineral concentrations and haematological and biochemical blood parameters in broilers

Kwiecień

Samolińska

Bujanowicz-Haraś

2015

Animal Physiology Nutrition

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“…Our data do not agree with numerous other publications which report an association between iron deficiency anemia and hyperlipidemia [1][2][3][4][5][6][7]. Differences in type and levels of dietary fat, fiber content, and levels of vitamins and minerals could affect degree of anemia and hyperlipidemia [33].…”

Section: Discussioncontrasting

confidence: 99%

“…Severe iron deficiency anemia produced by either dietary means or by acute hemolysis is associated with marked lipemia in both animal models [1][2][3] and humans [4][5][6][7]. The mechanisms involved in the etiology of hyperlipidemia in iron-deficiency anemia are not understood fully.…”

Section: Introductionmentioning

confidence: 99%

Anemia is associated with hypercholesterolemia in rats only when liver iron is elevated

Fields

Lewis

2001

J. Trace Elem. Exp. Med.

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The objective of this study was designed to answer the question whether anemia per se is a potential inducer of hyperlipidemia. For this purpose, two types of anemia were induced; copper‐deficiency and iron‐deficiency anemia. Seventy‐two weanling male Sprague–Dawley rats were assigned randomly to 12 dietary groups differing in the levels of copper, iron, and the types of dietary carbohydrates. The rats were fed either a copper‐deficient (0.6 μg Cu/g) or adequate (6.0 μg Cu/g) diets containing either low (5), adequate (50), or high (500) μg Fe/g The diets also contained fructose or starch as the sole source of dietary carbohydrate. All iron‐deficient rats became anemic. Copper‐deficient rats developed anemia only when they consumed the diet containing fructose and when they consumed the high levels of dietary iron. Anemia, per se, was not associated with elevated levels of blood cholesterol or triglycerides unless the diet consumed was deficient in copper and was either high in iron or contained fructose. The most severe hypercholesterolemia developed in rats fed the copper‐deficient diet, which contained high levels of iron. These rats also exhibited high levels of liver iron. The highest degree of hypertriglyceridemia developed in copper‐deficient rats fed the fructose‐based diet. Data show that anemia per se was not associated with hypercholesterolemia. Similarly, excess liver iron by itself was not accompanied with hypercholesterolemia. The combination of anemia with excess liver iron was instrumental in raising blood cholesterol. J. Trace Elem. Exp. Med. 14:81–87, 2001. Published 2001 Wiley‐Liss, Inc.

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“…These results are consistent with the reports of investigators , demonstrating that dietary iron supplementation Licensed Under Creative Commons Attribution CC BY increases plasma lipids in iron deficient girls and in rats. Ohira et al [35] found that total cholesterol concentrations were elevated following an increase in haemoglobin levels by transfusion and iron treatment. They also reported that the concentration of red blood cells might affect cholesterol synthesis or its mobilization from tissue to plasma.…”

Section: Discussionmentioning

confidence: 99%

Effect of Iron Supplementation on Plasma Lipid Levels in Pregnant Anemic Women

2016

IJSR

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Serum lipid levels in iron deficiency anemia and effects of various treatments.

Cited by 13 publications

References 13 publications

Effects of iron–glycine chelate on growth, carcass characteristic, liver mineral concentrations and haematological and biochemical blood parameters in broilers

Effects of iron–glycine chelate on growth, carcass characteristic, liver mineral concentrations and haematological and biochemical blood parameters in broilers

Anemia is associated with hypercholesterolemia in rats only when liver iron is elevated

Effect of Iron Supplementation on Plasma Lipid Levels in Pregnant Anemic Women

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