Serum lipid levels were related to socio‐demographic characteristics in a German population‐based child cohort

Dathan-Stumpf, Anne; Vogel, Mandy; Rieger, Kristin; Thiery, Joachim; Hiemisch, Andreas; Kieß, Wieland

doi:10.1111/apa.13438

Cited by 19 publications

(12 citation statements)

References 19 publications

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“…The quantity of dietary cholesterol intake and serum lipid profiles may be affected by socio-economic factors [46, 47]. Our analysis provided such evidence that cholesterol/egg intakes and some serum cholesterol were not uniformly distributed across educational groups.…”

Section: Discussionmentioning

confidence: 72%

Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study

Zhang

Wang

et al. 2019

Mol Neurodegeneration

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Background: Previous studies regarding the cholesterol-cognition relationship in midlife have generated conflicting results. We thus investigated whether dietary and blood cholesterol were associated with cognitive decline. Methods: Participants were drawn from a large cohort study entitled the Effects and Mechanism Investigation of Cholesterol and Oxysterol on Alzheimer's disease (EMCOA) study. We included 2514 participants who completed a selection of comprehensive cognitive tests and were followed for an average of 2.3 years. Blood concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) were assessed and dietary intakes were investigated by food frequency questionnaire (FFQ) at baseline. Apolipoprotein E (APOE) was genotyped by Kompetitive Allele Specific PCR (KASP) sequencing. Non-highdensity lipoprotein cholesterol (Non-HDL-C) and LDL-C/HDL-C ratio were calculated. The longitudinal effects of dietary and blood cholesterol on risk of global cognitive decline (decrease in Montreal Cognitive Assessment (MoCA) > 2 points) were examined using Cox proportional hazards models. The nonlinear associations with global and domain-specific cognitive decline was evaluated with mixed effect linear models.Results: In Cox proportional hazards models, neither cholesterol nor egg intake was associated with a higher risk of accelerated global cognitive decline. In contrast, the higher serum concentrations of TC, LDL-C, non-HDL-C and LDL-C/HDL-C ratio were positively associated with accelerated global cognitive decline regardless of being evaluated continuously or categorically while higher HDL-C was positively associated with accelerated global cognitive decline only when being evaluated categorically (all P < 0.05). In mixed effect linear models, quadratic and longitudinal relations of dietary cholesterol and egg intakes to global cognition, processing speed and executive function were observed. Moreover, there were inverted U-shaped relations of HDL-C, with processing speed and executive function but U-shaped relations of HDL-C and LDL-C/HDL-C ratio with verbal memory. Adverse linear associations of higher LDL-C and LDL-C/HDL-C ratio with multiple cognitive comes were also revealed. Additionally adjusting for APOE genotype did not modify cholesterol-cognition associations. Dietary and serum cholesterol had variable associations with global and domain-specific cognitive decline across educational groups.Conclusion: Differential associations between dietary/serum cholesterol and cognitive decline across different domains of function were observed in a particular population of middle-aged and elderly Chinese. Interventions to improve cognitive reserve regarding dietary instruction and lipid management should be tailored according to specific target.(Continued on next page)

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Section: Discussionmentioning

confidence: 72%

Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study

Zhang

Wang

et al. 2019

Mol Neurodegeneration

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“…This study provides an openly available R package including convenient functions to transform measurement values into SDS values for ALT, AST, and GGT. Regarding limitations, others have already reported that the composition of the LIFE Child cohort differs from the general distribution in the city of Leipzig, especially regarding the social background of the participants . Children from socially disadvantaged families were under‐represented in the LIFE Child study, possibly because of a less‐pronounced health awareness .…”

Section: Discussionmentioning

confidence: 94%

“…Regarding limitations, others have already reported that the composition of the LIFE Child cohort differs from the general distribution in the city of Leipzig, especially regarding the social background of the participants. (38) Children from socially disadvantaged families were under-represented in the LIFE Child study, possibly because of a less-pronounced health awareness. (39) Because of the ethnic composition of the city of Leipzig and under-representation of nonwhites, this study does not describe the potential influence of ethnicity on transaminases.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

New pediatric percentiles of liver enzyme serum levels (alanine aminotransferase, aspartate aminotransferase, γ‐glutamyltransferase): Effects of age, sex, body mass index, and pubertal stage

Bussler¹,

Vogel²,

Pietzner³

et al. 2018

Hepatology

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105

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Current reference values of ALT, AST, and GGT serum levels were calculated for children between 11 months and 16.0 years, using modern analytical and statistical methods. This study extends the current knowledge about transaminases by revealing influences of age, sex, BMI, and puberty on serum concentrations of all three parameters and has for these parameters one of the largest sample sizes published so far. (Hepatology 2017).

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“…This suggested that the association between the only-child status and dyslipidemia may be partly dependent on these factors. It was suggested that triglycerides level was inversely associated with education and salary in some developed areas 34,35 . However, other studies found that individuals of lower socioeconomic status (SES) had lower levels of TC and LDL-C in developing areas 36,37 .…”

Section: Discussionmentioning

confidence: 99%

The differences of lipid profiles between only children and children with siblings: A national survey in China

Cai

Lin

et al. 2019

Sci Rep

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With the increasing number of the one-child family, it is important to investigate whether the only-child status is associated with dyslipidemia. Among a national sample of 65,347 Chinese children aged 6–17 years, 16,100 lipid profiles were available. Children’s height, weight, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured. In comparison to children with siblings, only children (OC) were more likely to be boys and live in urban areas. OC had less physical activity, less fried food intake, but more meat and dairy intakes. OC had significantly higher levels of TC (3.97 ± 0.78 vs. 3.89 ± 0.77) and LDL-C (2.12 ± 0.65 vs. 2.06 ± 0.64) in the overall group, and also in the subgroups of rural boys and girls. The prevalence of hyper-TC (5.48% vs. 4.43%) and hyper-LDL-C (3.97% vs. 2.96%) were significantly higher in OC than their counterparts. Furthermore, we found higher odds of hyper-LDL-C [1.43 (1.12, 1.83)] in OC after adjustments. In the subgroup analysis, only-child status was associated with increased risk of hyper-TC [1.86 (1.06, 3.26)] and hyper-LDL-C [2.65 (1.14, 6.16)] among rural boys, and hyper-LDL-C among rural girls [2.20 (1.14, 4.22)]. In conclusion, higher levels of TC and LDL-C were found in OC especially for rural children. Being an only-child was associated with increased risk of hyper-LDL-C.

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Serum lipid levels were related to socio‐demographic characteristics in a German population‐based child cohort

Abstract: Adolescents with higher family wealth and social status showed a lower cardiovascular risk profile, as measured by the concentrations of HDL cholesterol and triglycerides as well as ApoA1 and B.

Cited by 19 publications

References 19 publications

Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study

Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study

New pediatric percentiles of liver enzyme serum levels (alanine aminotransferase, aspartate aminotransferase, γ‐glutamyltransferase): Effects of age, sex, body mass index, and pubertal stage

The differences of lipid profiles between only children and children with siblings: A national survey in China

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