Serum Lipid Profile and Its Association with Diabetes and Prediabetes in a Rural Bangladeshi Population

Bhowmik, Bishwajit; Siddiquee, Tasnima; Mujumder, Anindita; Afsana, Faria; Ahmed, Tareen; Mdala, Ibrahimu; Moreira, Nayla Cristina do Vale; Khan, Abul Kalam Azad; Hussain, Akhtar; Holmboe‐Ottesen, Gerd; Omsland, Tone Kristin

doi:10.3390/ijerph15091944

Cited by 129 publications

(109 citation statements)

References 56 publications

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“…In addition, these combined metabolic disorders like hypertension and hyperlipidemia may lead to cardio-cerebrovascular diseases and stroke, which may eventually lead to death (Sun et al, 2014). One study revealed that Total cholesterol (TC), raised triglycerides (TGs) and low HDL-cholesterol (HDL-c) were increased significantly in type-2 DM patients (Bhowmik et al, 2018). HDL-c showed an inverse association with body mass index (BMI); but LDL-c, TC and TGs were positively correlated with BMI (Omotoye et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of dyslipidemia and its correlation with anthropometric and blood pressure variables among type-2 diabetic patients

Wube¹,

Alemayehu²,

Hirigo³

2020

J. Diabetes Endocrinol.

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Co-morbidity of hypertension and dyslipidemia are found to be high in type-2 diabetes mellitus (DM) patients particularly with poor glycemic control. This study was aimed to assess the prevalence of dyslipidemia and its correlations with anthropometric and blood pressure variables among type-2 DM patients. The study was conducted on 314 type-2 DM patients at Hawassa University Comprehensive Specialized Hospital from February 28 to May 30, 2017. Socio-demographic and other data was collected using interview-directed structured questionnaire. In addition, serum biochemical parameters determined after overnight fasting and dyslipidemia was defined based on United State National Cholesterol Education program-III criteria. Statistical analysis such as Chi-square, student's t-test/ Mann-Whitney U test, and Pearson correlation coefficient were conducted using Statistical Package for Social Sciences (SPSS) Version 20. The result showed that two hundred eight six (91.1%) participants had a minimum of one lipid parameter abnormal, which is well suited for the diagnosis of dyslipidemia. The prevalence of low HDL-cholesterol, high LDL-cholesterol, triglycerides and TC (total cholesterol) were 60.8, 14.3, 70.4 and 32.8%, respectively. The mean values of TC, LDL-cholesterol and uric acid (UA) were significantly higher among patients with body max index (BMI) ≥25 kg/m 2 when compared to those with BMI <25 kg/m 2 (p<0.01 for all). In addition, TC and TG were significantly higher among patients with BP ≥130/85 mmHg when compared to those patients with BP <130/85 mmHg (p<0.001 for both parameters). Triglycerides was significantly correlated with BMI, UA and hypertension (r=0.326, 0.553 and 0.22), respectively. TC showed significant correlation with BMI, UA and fasting blood sugar (FBS) (r=0.326, 0.298 and 0.132), respectively. Moreover, LDL-cholesterol was significantly correlated with waist circumference, BMI and FBS (r=0.16, 0.189 and 0.173), respectively. In conclusion, dyslipidemia is significantly higher in diabetes patients and it correlated with BMI, WC, blood pressure and UA. Therefore, lipid profiles should be performed periodically through treatment follow-up and proper management of correlated factors is vital in order to limit risks of cardiovascular diseases.

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Section: Introductionmentioning

confidence: 99%

Prevalence of dyslipidemia and its correlation with anthropometric and blood pressure variables among type-2 diabetic patients

Wube¹,

Alemayehu²,

Hirigo³

2020

J. Diabetes Endocrinol.

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“…Multiple set of studies have been conducted to establish the importance of improving dyslipidemia in relation to diabetes [29,30] and so effects of metformin on the same [31]. Our data too, revealed the beneficial effects of metformin on serum cholesterol, TG and HDL but in the setting of PCOS.…”

Section: Discussionmentioning

confidence: 50%

Effectiveness of Probiotics, Metformin and Their Combination Therapy in Ameliorating Dyslipidemia Associated With PCOS

Zafar

Hassan

Ismail

et al. 2019

JPRI

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Background: Polycystic ovary syndrome (PCOS) is a heterogeneous metabolic disorder affecting women of the child-bearing age. Alteration in lipid profile is one of the troublesome features faced by PCOS patients that need to be treated. Aim: The purpose of this study was to compare the effects of Probiotics, Metformin and their Combination therapy on lipid profile in women suffering from PCOS. Study Design: Single-Centered Randomized Controlled Trial. Setting: Gynecological clinic of Karachi at Tertiary care Hospital from December 2018 to May 2019. Patients and Methods: Total 78 PCOS patients of age between 18 to 40 years were involved in this trial rendering to Rotterdam criteria. After taking written and informed consent they were randomly allocated to three groups and were received: Metformin 500 mg B.D (n = 26), Probiotic Capsule 180 mg B.D (n = 26) and Combination of Metformin 500 mg B.D / Probiotic Capsule 180 mg B.D for 12-weeks. Lipid profile was measured at baseline and after 12-weeks of intervention along with the body weight. In the end, pre versus post therapy and comparison of different group’s results were analyzed. Results: Metformin and Met/Pro Combination groups resulted in a significant reduction in Total Cholesterol (TC) as compared to Probiotic group. Fall in Low-Density Lipoprotein Cholesterol (LDL-C) levels were noteworthy after Probiotics and Met/Pro treatment. Serum TG concentrations were significantly reduced in all the groups. High-Density Lipoprotein Cholesterol (HDL-C) levels were slightly elevated after Probiotics treatment, which was not statistically significant but Metformin and Met/Pro group increases it to the significant value. No substantial change was found in the Very Low-Density Lipoprotein Cholesterol VLDL-C levels in any of the three groups. Conclusion: Overall, Probiotics treatment in PCOS women for 12 weeks exhibited noteworthy changes in TG, and LDL-C levels. Metformin markedly improve Cholesterol, TG and HDL-C. However, Met/Pro improved all the lipid changes to the significant value except for VLDL-C.

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“…In addition, high levels of TG in combination with low levels of HDL showed the highest association with T2DM and PD. The levels of high CHOL, high TG, and low HDL were more elevated among subjects with T2DM and PD (13).…”

Section: Resultsmentioning

confidence: 87%

“…For instance, a meta-analytic review demonstrated that lipid pro le disorders signi cantly associated with T2DM (12). A community based cross-sectional survey showed a strong association between serum lipid pro le with T2DM and PD (13).…”

Section: Introductionmentioning

confidence: 99%

Patterns of changes in serum lipid profile in prediabetic patients: Results from a 16-year prospective cohort study

Safari

Amini

Aminorroaya

et al. 2020

Preprint

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Background Lipids abnormality pervasively is associated with the risk of Type 2 diabetes mellitus. To the best of our knowledge, there is no study that examined the longitudinal changes in wide range of serum lipid profile in prediabetic subjects in association with the risk of Type 2 diabetes mellitus in future. This study aimed to identify the patterns of changes in lipids profile over time in prediabetic patients and classify these subjects in order to highlight the high risk people for future diabetes risk. Methods This prospective 16-year (2003–2019) cohort study was conducted among 1228 prediabetic subjects. The study subjects followed over time and changes in their lipid profile include Triglycerides, Cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol was evaluated. Latent Markov model was used for data analysis. Results Mean (standard deviation) age of subjects was 44.00 (6.86) years and 73.6% were female. Latent Markov model identified two latent states of subjects in terms of change in lipid profile: low tendency to progress diabetes/ high tendency to progress diabetes (74%/ 26%). Latent Markov model showed that the transition probability from “low tendency to progress diabetic” state to “high tendency to progress diabetic” state was lower than the transition probability from “high tendency to progress diabetic” state to “low tendency to progress diabetic” state. Conclusion In conclusion, abnormality of serum lipid profile remains a significant and growing problem in prediabetic subjects as high risk population. The reduction in the problem burden will require changes at the policy level as well as at the personal level.

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Serum Lipid Profile and Its Association with Diabetes and Prediabetes in a Rural Bangladeshi Population

Cited by 129 publications

References 56 publications

Prevalence of dyslipidemia and its correlation with anthropometric and blood pressure variables among type-2 diabetic patients

Prevalence of dyslipidemia and its correlation with anthropometric and blood pressure variables among type-2 diabetic patients

Effectiveness of Probiotics, Metformin and Their Combination Therapy in Ameliorating Dyslipidemia Associated With PCOS

Patterns of changes in serum lipid profile in prediabetic patients: Results from a 16-year prospective cohort study

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