Serum lipid profile in alcoholic cirrhosis: A study in a teaching hospital of north-eastern India

Phukan, Jyoti Prakash; Sinha, Anuradha; Deka, Jatindra

doi:10.4103/0300-1652.108886

Cited by 15 publications

(12 citation statements)

References 31 publications

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“…The age differences between each demographic region are likely due to the care setting from which data were collected (population vs hospital-based), age structure of the population itself, and patterns of alcohol consumption. In fact, there were no differences in the mean age of hospitalized ALD patients in each geographic location 48–50 .…”

Section: Factors Associated With Aldmentioning

confidence: 86%

Alcoholic Liver Disease in Asia, Europe, and North America

2016

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Alcoholic liver diseases (ALD) comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from steatosis to more severe signs and symptoms of liver disease associated with inflammation, such as those observed in patients with alcoholic hepatitis or cirrhosis. Although the relationship between alcohol consumption and liver disease is well established, severe alcohol-related morbidities develop in only a minority of people who consume alcohol in excess. Inter-individual differences in susceptibility to the toxic effects of alcohol have been extensively studied—they include pattern of alcohol consumption, sex, environmental factors (such as diet), and genetic factors, which vary widely among different parts of the world. ALD is becoming more common in many parts of Asia but is decreasing in Western Europe. Treatment approaches, including availability of medications, models of care, and approach to transplantation, differ among regions.

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Section: Factors Associated With Aldmentioning

confidence: 86%

Alcoholic Liver Disease in Asia, Europe, and North America

2016

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“…Imbalance in serum lipoprotein can be due to cirrhosis of the liver, where cholesterol of low-density lipoprotein (LDL) variant and high-density lipoprotein (HDL) variant are reduced [ 5 ]. Dyslipidemia reported in patients of CLD is remarkable in contrast with other causes of secondary dyslipidemia as the composition, appearance, serum levels, and mobility of lipoproteins is disturbed [ 3 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Pattern of Dyslipidemia in Chronic Liver Disease Patients

Farooque¹,

Lohano²,

Dahri³

et al. 2021

Cureus

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A substantial proportion of patients with chronic liver disease had hyperlipidemia which varied with the severity of disease on Child-Pugh classification. Routine monitoring of the lipid profile of such patients is necessary for timely identification and management of dyslipidemia to improve the outcome of such patients. It also suggests an important role of lipid profile in the risk stratification and treatment of chronic liver disease patients and warrants further studies in this regard.

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“…Similarly, some studies showed a decrease in triglyceride in cirrhosis[ 36 ]. Liver biosynthesis is reduced with the progression of cirrhosis[ 37 ]. Although there were mixed findings of the relationship between cholesterol values and cirrhosis, our findings are compatible with the abovementioned relationship.…”

Section: Discussionmentioning

confidence: 99%

Cannabis use history is associated with increased prevalence of ascites among patients with nonalcoholic fatty liver disease: A nationwide analysis

Choi

Weiss

Nasir

et al. 2020

WJH

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BACKGROUND Recent studies have revealed the endocannabinoid system as a potential therapeutic target in the management of nonalcoholic fatty liver disease (NAFLD). Cannabis use is associated with reduced risk for NAFLD, we hypothesized that cannabis use would be associated with less liver-related clinical complications in patients with NAFLD. AIM To assess the effects of cannabis use on liver-related clinical outcomes in hospitalized patients with NAFLD. METHODS We performed a retrospective matched cohort study based on querying the 2014 National Inpatient Sample (NIS) for hospitalizations of adults with a diagnosis of NAFLD. The NIS database is publicly available and the largest all-payer inpatient database in the United States. The patients with cannabis use were selected as cases and those without cannabis were selected as controls. Case-control matching at a ratio of one case to two controls was performed based on sex, age, race, and comorbidities. The liver-related outcomes such as portal hypertension, ascites, varices and variceal bleeding, and cirrhosis were compared between the groups. RESULTS A total of 49911 weighed hospitalizations with a diagnosis of NAFLD were identified. Of these, 3820 cases were selected as the cannabis group, and 7625 non-cannabis cases were matched as controls. Patients with cannabis use had a higher prevalence of ascites (4.5% vs 3.6%), with and without cannabis use, P = 0.03. The prevalence of portal hypertension (2.1% vs 2.2%), varices and variceal bleeding (1.3% vs 1.7%), and cirrhosis (3.7% vs 3.6%) was not different between the groups, with and without cannabis use, all P > 0.05. Hyperlipidemia, race/ethnicity other than White, Black, Asian, Pacific Islander or Native American, and higher comorbidity score were independent risk factors for ascites in the cannabis group. Among non-cannabis users, obesity and hyperlipidemia were independent protective factors against ascites while older age, Native American and higher comorbidity index were independent risk factors for ascites. CONCLUSION Cannabis was associated with higher rates of ascites, but there was no statistical difference in the prevalence of portal hypertension, varices and variceal bleeding, and cirrhosis.

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Serum lipid profile in alcoholic cirrhosis: A study in a teaching hospital of north-eastern India

Cited by 15 publications

References 31 publications

Alcoholic Liver Disease in Asia, Europe, and North America

Alcoholic Liver Disease in Asia, Europe, and North America

The Pattern of Dyslipidemia in Chronic Liver Disease Patients

Cannabis use history is associated with increased prevalence of ascites among patients with nonalcoholic fatty liver disease: A nationwide analysis

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