Serum lipid profile in psoriatic patients: correlation between vascular adhesion protein 1 and lipoprotein (a)

Abstract

Psoriasis is a chronic inflammatory skin disease characterized by excessive cellular replication. Apolipoproteins are genetically determined molecule whose role has been implied in cardiovascular pathology. Vascular adhesion protein-1 (VAP-1) is an adhesion molecule with an enzymatic activity that partakes in the migration process of lymphocytes into sites of inflammation. Our purpose was to evaluate the plasma lipid profiles, apolipoproteins (A1, B) and Lp (a) and VAP-1 in order to compare the lipid profile in psoriatic patients with non-affected persons and correlation between VAP-1 and Lp (a). We determined serum concentrations of lipids, lipoproteins , apolipoproteins and VAP-1 in 90 patients with psoriasis and 90 age matched controls. Serum Lp (a), apo A1 and apo B were measured by immunoprecipitation assays, and the lipids and lipoproteins were measured by enzymatic methods.The VAP-1 were measured by ELISA method. The mean levels of total cholesterol, LDL, apo B and VAP-1 in patients with psoriasis were found to be significantly higher than those of healthy subjects (P<0.05. In psoriatic patients, elevation of VAP-1 correlated with elevation of Lp (a) (p = 0.025). This study shows that high serum lipid level and VAP-1, is significantly more common in psoriasis. This fact may be responsible for higher prevalence of cardiovascular accident in psoriatic patients.

Methylentetrahydrofolatereductase (rs1801133) polymorphism and psoriasis: contribution to oxidative stress, lipid peroxidation and correlation with vascular adhesion protein 1, preliminary report

“…Oxidative stress is also believed to have determinant role in the rate of disease development and progression complications in psoriatic patients . These results are in agreement with previous studies; VAP‐1, MDA and APOB levels and ratio APOB/APOA1 increase in psoriasis . Several reports suggest that persons with psoriasis have a proatherogenic lipoprotein profile, including hypertriglyceridemia, increased LDL‐C, very low density lipoprotein (VLDL) and decreased HDL‐C concentration .…”

“…Recently, Nemati et al . demonstrated that psoriasis patients had significantly higher serum level of VAP‐1 than those of controls groups.…”

Study of Lipid profile and Paraoxonase-1 Activity in Psoriatic patients

“…This is in accordance with Aldona et al [12] who also found increased level of total cholesterol in psoriatic patients as compared to control group. Nemati et al [13], Piskins et al [3], Javidi et al [14] and Aldhalimi et al [15] also support our results.…”

Artesunate–amodiaquine combination therapy in the absence of malarial parasite infection induces oxidative damage in female rats

“…It is widely accepted that alterations in the levels of lipid profile parameters such as TC, LDL‐c, HDL‐c and TG are primary risk factors of atherosclerosis . Indeed, studies have revealed that elevated LDL‐cholesterol and decreased HDL‐c concentrations increase the risk of coronary heart disease .…”