Serum Lipid Values in Children with Beta Thalassemia Major

Arıca, Vefik

doi:10.4172/2161-0665.1000130

Cited by 12 publications

(17 citation statements)

References 15 publications

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“…neither low nor high. Results of present study correlate well with previous study [14][15][16][17][18][19] .…”

Section: Discussionsupporting

confidence: 93%

“…This alteration is likely due to diminished hepatic biosynthesis as of anemia and iron overload, while a reduced extra hepatic lipolytic activity could account for the rise in circulating TG [14] . Iron-loading and the effects of repeated blood transfusions induce a hepatic acute-phase response, which could determine an LDL-class shift towards protein-rich, denser particles [14,17] .…”

Section: Discussionmentioning

confidence: 99%

“…Thalassemic patients are also subjected to peroxidative tissue injury [11,12] . Variants of lipoproteins, cholesterol and triglyceride in thalassemic patients show marked oxidative modification due to free radical injury that could represent an event leading to pathogenesis [13] .…”

Section: Introductionmentioning

confidence: 99%

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Study of Serum Lipid Profile in Beta-Thalassemia Major Patients

Doshi¹,

Sutay²

2016

jmscr

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“…neither low nor high. Results of present study correlate well with previous study [14][15][16][17][18][19] .…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Study of Serum Lipid Profile in Beta-Thalassemia Major Patients

Doshi¹,

Sutay²

2016

jmscr

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“…[4] But Infections such as HBV, HCV, and HIV can be observed through frequent transfusions in children with Beta Thalassemia major (BTM). [5] Various endocrine, cardiac, and hepatic diseases may occur depending, on excessive iron-loading. Failure of pubertal growth, delay or absence of sexual development, amenorrhea, sexual dysfunction and infertility due to hypogonadism are well recognized disturbances of the hypothalamic -pituitary -gonadal axis in Beta Thalassemia patients.…”

Section: Section: Paediatricsmentioning

confidence: 99%

Growth And Puberty In Girls With B-Thalassemia Major And its Correlation With Chelation Therapy And Serum Ferritin Levels

Sutay¹,

Manjiri²,

Karlekar³

et al. 2017

Ann. Int. Med. Den.Res.

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Background: (1) To study FSH, LH and Estrogen levels and it's correlation with Serum Ferritin levels in Female Beta Thalassemia Major patients. (2) To study the correlation of these hormones and SMR with Serum Ferritin. (3) To compare these hormone levels and SMR of Patients with Controls. Study Design: It was a cross-sectional case control study done in a tertiary care centre in a large Metropolitan city over a period of 2 years. Methods: The study was approved by the Institutional ethical committee. The patients attending the Emergency, in-patient and outpatient Departments of Pediatrics Division of our institute were enrolled for the study as per the criteria given. It was a cross-sectional case control study done in patients who had already been diagnosed with beta thalassemia major (cases) and healthy girls (controls). The demographic data, ferritin levels, chelation therapy, SMR staging and hormonal essays of FSH, LH, estrogen and their correlation with blood transfusions and serum ferritin levels was studied. Also the hormone levels and SMR staging of patients with thalassemia major were compared with control group. Results: 56 girls having beta thalassemia major (cases) and 50 healthy girls not suffering from any ailments as (controls) per inclusion and exclusion criterion were enrolled in this study. Estimation of FSH in test and control subjects revealed that The difference was not significant in the age group of 8-12 years (P=0.323). The FSH values of cases >12 years were significantly lower than those of controls (P<0.001). Estimation of oestrogen and LH revealed that these values were significantly lower in Thalassemics as compared to non thalassemics in both age groups (P<0.001). 0% Cases and 26.3% Controls had attained Menarche in the age group of 8-12 years whereas 11.4% Cases and 93.3% Controls in the age group of >12 years had attained Menarche . In our study the mean age of attainment of menarche was 14.5 in thalassemics and 11.5 in non thalassemics. The differece was found to be very highly significant (P<0.001). The association of serum ferritin and FSH, LH and oestrogen levels revealed that a statistically significant association was found in between Sr ferritin and FSH (P=0.015) and oestrogen (0.008). While for LH the difference was insignificant (P=0.174). Association of FSH,LH and oestrogen with duration of chelation therapy showed that there was no significant difference in between FSH,LH and oestrogen levels with respect to duration of chelation therapy. Conclusion: Our study concluded that Delayed growth and Puberty is a common complication of beta thalassemia major. Regular chelation therapy reduces serum ferritin levels and improves FSH, LH and estrogen levels.

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“…Deficiency of zinc causes growth retardation, defective collagen synthesis, skeletal abnormalities, poor wound healing, impaired immune function, night blindness, sickle cell anemia and impaired protein synthesis (Gropper & Smith, ). Previous studies showed either lower (Arıca, Arıca, Özer, & Çevik, ; Keikhaei, Badavi, Pedram, Zandian, & Fakher Rahim, ; Mahyar et al, ) or higher concentrations of Zn in patients (Mehdizadeh, Zamani, & Tabatabaee, ), and also showed correlation with Cu (Bashir, ; Fukushima et al, ; Mahyar et al, ; Naji, ), which is an important constituent of hemoglobin. In this study, Cu levels were found to be higher in patients as compared with controls.…”

Section: Discussionmentioning

confidence: 97%

Quantitative assessment of metal dysregulation in β‐thalassemia patients in comparison with healthy controls by ICP‐MS and chemometric analyses

Farooq

Mazhar

Siddiqui

et al. 2018

Biomedical Chromatography

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β‐Thalassemia is one of the most common inherited disorders and is widely distributed throughout the world. Owing to severe deficiencies in red blood cell production, blood transfusion is required to correct anemia for normal growth and development but causes additional complications owing to iron overload. The aim of this study is to quantify the biometal dysregulations in β‐thalassemia patients as compared with healthy controls. A total of 17 elements were analyzed in serum samples of β‐thalassemia patients and healthy controls using ICP‐MS followed by chemometric analyses. Out of these analyzed elements, 14 showed a significant difference between healthy and disease groups at p < 0.05 and fold change >3. A PLS‐DA model revealed an excellent separation with 89.8% sensitivity and 97.2% specificity and the overall accuracy of the model was 92.2%. This metallomic study revealed that there is major difference in metallomic profiling of β‐thalassemia patients specifically in Co, Mn, Ni, V and Ba, whereas the fold changes in Co, Mn, V and Ba were found to be greater than that in Fe, providing evidence that, in addition to Fe, other metals are also altered significantly and therefore chelation therapy for other metals may also needed in β‐thalassemia patients.

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Serum Lipid Values in Children with Beta Thalassemia Major

Cited by 12 publications

References 15 publications

Study of Serum Lipid Profile in Beta-Thalassemia Major Patients

Study of Serum Lipid Profile in Beta-Thalassemia Major Patients

Growth And Puberty In Girls With B-Thalassemia Major And its Correlation With Chelation Therapy And Serum Ferritin Levels

Quantitative assessment of metal dysregulation in β‐thalassemia patients in comparison with healthy controls by ICP‐MS and chemometric analyses

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