Serum Lipids and Colorectal Adenoma among Male Self-Defence Officials in Northern Kyushu, Japan

Kono, Suminori; Ikeda, Norihiro; Yanai, Fumio; Yamamoto, Masaru; Shigematsu, Takao

doi:10.1093/ije/19.2.274

Cited by 33 publications

(27 citation statements)

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“…Our results were consistent with those of previous studies that reported a positive association between serum triglycerides and colorectal adenoma [5][6][7][8][9][10]. The association was confirmed by dose-dependent relationships between serum levels of triglycerides and the number of adenomas, which is associated with the risk of colorectal cancer [11].…”

Section: Discussionsupporting

confidence: 93%

“…Most epidemiologic studies [5][6][7][8][9][10] have consistently demonstrated that serum levels of triglycerides are associated with the risk of colorectal adenoma, a precursor lesion of colorectal cancer [11]. Recently, an animal study reported that an age-dependent hyperlipidemic state along with a suppressed lipoprotein lipase, which catalyzes hydrolysis of triglycerides, occurs in Apc-deficient mice [12].…”

Section: Introductionmentioning

confidence: 99%

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Serum triglycerides and colorectal adenoma in a case–control study among cancer screening examinees (Japan)

Otani¹,

Iwasaki²,

Ikeda³

et al. 2006

Cancer Causes Control

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Serum triglycerides and colorectal adenoma in a case–control study among cancer screening examinees (Japan)

Otani¹,

Iwasaki²,

Ikeda³

et al. 2006

Cancer Causes Control

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“…Nine studies were conducted in the USA (16,18,20,32,35,(37)(38)(39)(40) , one in Sweden (42) , five in Korea (6,9,10,22,27) , two in China (23,30) , eight in Japan (8,24,26,28,29,31,36,43) , one in Austria (41) and three in European countries (4,17,34) (Tables 1 and 2). Pooled analysis showed a significant association between serum TAG and CRN (n 29 studies; summary RR = 1·08; 95 % CI 1·05, 1·12, P < 0·00001; Fig.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Two studies were conducted in the USA (20,39) , one in Germany (19) , three in Korea (9,10,22) and three in Japan (28,29,36) ( Table 2). The results from nine studies showed that serum TC had a significant association with risk of CRA (RR = 1·04; 95 % CI 1·01, 1·09, P = 0·02) and there was no significant heterogeneity among these studies (Q = 5·26, P value for heterogeneity = 0·73, I 2 = 0 %; Table 3).…”

Section: Study Characteristicsmentioning

confidence: 99%

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The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis

Tian

Wang

et al. 2015

Public Health Nutr.

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Objective: There have been inconsistent results published regarding the relationship between dyslipidaemia and an increased risk of colorectal neoplasia (CRN), including colorectal adenoma (CRA) and colorectal cancer (CRC). We conducted a meta-analysis to explore the relationship between dyslipidaemia and CRN. Design: We identified studies by performing a literature search using PubMed, EMBASE and the Science Citation Index through October 2013. Setting: We analysed thirty-three independent studies reporting the association between CRN and at least one of the selected lipid components, including total cholesterol (TC), TAG, HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C). Subjects: CRN cases (n 21 809) were identified. Results: Overall, people with high levels of serum TAG (risk ratio (RR) = 1·08; 95 % CI 1·05, 1·12, P < 0·00001) and LDL-C (RR = 1·07; 95 % CI 1·00, 1·14, P = 0·04) presented an increased prevalence of CRN. Subgroup analyses revealed that high levels of serum TC (RR = 1·04; 95 % CI 1·01, 1·09, P = 0·02), TAG (RR = 1·06; 95 % CI 1·03, 1·10, P = 0·0009) and LDL-C (RR = 1·11; 95 % CI 1·04, 1·19, P = 0·003) increased the risk of CRA but not of CRC. No association between serum HDL-C and risk for CRN (including CRA and CRC) was observed. Conclusions: Both TAG and LDL-C were significantly associated with an increasing prevalence of CRN. High levels of serum TC, TAG and LDL-C were positively associated with CRA but not with CRC. No significant association was observed between levels of serum HDL-C and CRN. Keywords Serum lipids Colorectal adenomaColorectal cancer TAG Meta-analysis Colorectal cancer (CRC) is reported to be the fourth most commonly diagnosed cancer and is the second most common cause of cancer deaths in North America (1) . CRC is believed to arise from colorectal adenoma (CRA) through a sequence from adenoma to adenocarcinoma as a consequence of a limited set of molecular events that largely originate with a relatively benign adenoma that progresses to cancer (2) . Accumulated data indicate that metachronous lesions occur at a rate of 20 to 30 % per year in post-polypectomy patients. The propensity to develop CRA identifies a sizeable subgroup of the population at an enhanced risk for subsequent adenoma formation and colorectal carcinoma. This indicates that identifying risk factors associated with CRN is essential for the reduction of colorectal carcinoma.The positive association between obesity and CRA prevalence demonstrates an underlying dose-response relationship according to BMI (3) . Timely screening of obese patients for CRA is thus recommended. Dyslipidaemia is an important component of metabolic syndrome and is demonstrated to contribute to colorectal tumorigenesis through insulin resistance, oxidative stress and inflammatory † The first three authors contributed equally to this work.

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Comparison of some biochemical markers between early‐onset and late‐onset colorectal precancerous lesions: A single‐center retrospective study

Tang

Yang

et al. 2022

Clinical Laboratory Analysis

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Objective Given that the onset of diseases including colorectal cancer precursors is affecting younger individuals and that obesity is an important risk factor for early‐onset, we conducted a study to explore the biochemical profile of differences in serum between early‐onset patients and late‐onset colorectal precancerous lesions. Methods A total of 1447 patients, including 469 early‐onset patients and 978 late‐onset patients, were enrolled from the First Affiliated Hospital of Nanchang University (FAHNU), of which there were 311 sessile serrated adenoma/polyps (SSA/P) and 1136 normal adenomas. The distribution of the included categorical variables was compared via Pearson's chi‐squared test, whereas continuous variables were compared by using the nonparametric Kruskal–Wallis test and anova . Results Compared with late‐onset patients, the levels of total bilirubin and HDL‐C were lower ( p < 0.05), whereas triglyceride and uric acid levels were higher, in early‐onset patients. Interestingly, in the subgroup analysis, triglyceride and uric acid levels remained at higher levels, whereas HDL‐C remained at lower levels, in early‐onset patients than in late‐onset patients. Other characteristics, such as LDL‐C, drinking, γ‐GT, and the N/L ratio, were similar between the two groups. An additional analysis of the association of tumor size with markers showed that lower levels of HDL‐C and higher levels of uric acid were associated with increased tumor size ( p < 0.05). Conclusions Early‐onset CRC precursor cases exhibit higher levels of triglycerides and lower levels of HDL‐C than late‐onset cases. Additionally, levels of HDL‐C are negatively associated with tumor size, whereas uric acid was positively correlated with tumor size.

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Serum Lipids and Colorectal Adenoma among Male Self-Defence Officials in Northern Kyushu, Japan

Cited by 33 publications

References 0 publications

Serum triglycerides and colorectal adenoma in a case–control study among cancer screening examinees (Japan)

Serum triglycerides and colorectal adenoma in a case–control study among cancer screening examinees (Japan)

The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis

Comparison of some biochemical markers between early‐onset and late‐onset colorectal precancerous lesions: A single‐center retrospective study

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