SERUM LIPIDS AND Lp-PLA2 ACTIVITY IN MULTIPLE SCLEROSIS

Doğan, Halef Okan

doi:10.5505/tjb.2014.27147

Cited by 1 publication

(2 citation statements)

References 20 publications

(28 reference statements)

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“…The mean plasma HDL-C and LDL-C levels of patients with MS were not statistically different from the values of the controls. Dogan (17) evaluated the effect of lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and serum lipids in patients with MS. Their findings revealed that the serum lipid concentrations and Lp-PLA2 activity had no significant effect on MS and its progression. There were no statistically significant differences between patients with MS and healthy controls in terms of Lp-PLA2 activity, TChol, TG, HDL-C, LDL-C, atherogenic index of plasma (AIP), non-HDL-C and TChol to HDL-C ratio.…”

Section: Summary Of Main Findingsmentioning

confidence: 99%

“…Despite the chronic inflammatory character of MS, it is still unclear if and how lipoprotein levels are altered in patients with MS, and whether changes in feeding habits and body composition influence disease progression. This topic has been investigated in many studies in the literature (10,11,12,13,14,15,16,17,18). Weinstock-Guttman et al (10) investigated the associations of serum lipid profile variables [triglycerides (TG), high and lowdensity lipoproteins (HDL, LDL), and total cholesterol (TChol)] with disability and magnetic resonance imaging measurements in MS.…”

Section: Introductionmentioning

confidence: 99%

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Determination of Lipid Profile and Anthropometric Measurements of Multiple Sclerosis Patients: A Controlled Descriptive Study

Akbay¹,

Karakullukçu²,

Mutlu³

et al. 2019

tnd

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Objective: Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system. Lipid profile and anthropometric measurements might differ for patients with MS and healthy people. This study aimed to compare the lipid profiles and anthropometric measurements of patients with MS and healthy participants. Materials and Methods: The study was designed as a controlled descriptive study, consisting of 392 people (196 patients in the MS-MS group, and 196 healthy volunteers in the control group) who presented to a state hospital in Turkey. Blood samples were collected and lipid profiles (total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglycerides) were analyzed. Body mass index (BMI), waist-to-hip and waist-to-height ratios were calculated, and the parameters were compared between the groups. The relationship between the parameters and the presence of MS was investigated. Results: The weights, heights, hip circumferences, waist-to-hip and waist-to-height ratios of the people differed statistically significantly between the groups (p<0.05). There were no statistically significant differences between the groups in terms of the considered lipid profiles. The difference between the BMI values of males in the control and MS groups was statistically significant (p=0.006). Conclusion: The obtained results indicate that anthropometric measurements of patients with MS differ significantly from healthy individuals, although no significant difference could be observed in terms of lipid profiles. Most of the findings of this study are consistent with the literature and suggest that the anthropometric changes in individuals should be followed regularly to prevent a possible MS risk.

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Section: Summary Of Main Findingsmentioning

confidence: 99%