Serum lipids during the first year following acute spinal cord injury

Apstein, Michael D.; George, Bill

doi:10.1016/s0026-0495(98)90044-0

Cited by 28 publications

(21 citation statements)

References 13 publications

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“…62,63 In acute SCI, lipid levels are generally depressed and normalize within the first year. 64 Consequently, previously mentioned alterations in vascular function in individuals with SCI do not seem to be due to elevations in plasma lipids. However, beyond the first year after injury, individuals with SCI tend to develop elevated low-density lipoprotein cholesterol and total cholesterol levels, and continue to maintain lowered HDL cholesterol levels compared with able-bodied populations.…”

Section: Lipid Disordersmentioning

confidence: 97%

Challenges, concerns and common problems: physiological consequences of spinal cord injury and microgravity

et al. 2010

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Introduction: Similarities between the clinical presentation of individuals living with spinal cord injury (SCI) and astronauts are remarkable, and may be of great interest to clinicians and scientists alike. Objectives: The primary purpose of this review is to outline the manner in which cardiovascular, musculoskeletal, renal, immune and sensory motor systems are affected by microgravity and SCI. Methods: A comprehensive review of the literature was conducted (using PubMed) to evaluate the hallmark symptoms seen after spaceflight and SCI. This literature was then examined critically to determine symptoms common to both populations. Results: Both SCI and prolonged microgravity exposure are associated with marked deteriorations in various physiological functions. Atrophy in muscle and bone, cardiovascular disturbances, and alterations in renal, immune and sensory motor systems are conditions commonly observed not only in individuals with SCI, but also in those who experience prolonged gravity unloading. Conclusion: The preponderance of data indicates that similar physiological changes occur in both SCI and prolonged space flight. These findings have important implications for future research in SCI and prolonged space flight.

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Section: Lipid Disordersmentioning

confidence: 97%

Challenges, concerns and common problems: physiological consequences of spinal cord injury and microgravity

et al. 2010

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“…However, comparable data were found in patients, since acute chronic SCI subjects were found also to display low LDL-triglyceride levels. 21 Results in acute SCI patients and early Tx mice suggest that LDL-triglyceride changes are unlikely to contribute to DVT formation soon after trauma. If changes in deep-vein size, as seen in Tx mice, were to be found also in patients, it would strongly suggest that deepvein enlargement is a leading factor in DVT formation after SCI.…”

Section: Deep-vein Size and Blood Lipid Profilementioning

confidence: 99%

Early adaptive changes in chronic paraplegic mice: a model to study rapid health degradation after spinal cord injury

2007

Spinal Cord

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Study design: Literature review. Objective: To describe quantitatively some of most important anatomic, systemic, and metabolic changes occurring soon (one month) after spinal cord trauma in mice. Setting: University Laval Medical Center. Results: Significant changes in weight, mechanical and contractile muscle properties, bone histomorphometry and biomechanics, deep-vein morphology, complete blood count, immune cell count, lipid metabolism and anabolic hormone levels were found occurring within 1 month in completely spinal cord transected (Th9/10) mice. Conclusion: These data reveal that many changes in mice and humans are comparable suggesting, in turn, that this model may be a valuable tool for neuroscientists to investigate the specific mechanisms associated with rapid health degradation post-SCI.

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“…Apstein et al [16] examined the changes in serum lipid concentrations of patients with SCI following accidents. They described that HDL-C is markedly depressed following acute SCI and gradually returns toward normal by 1 year, and postulated that 44% of the increase in HDL-C is due to an increase in physical activity and 56% to the SCI itself.…”

Section: Discussionmentioning

confidence: 99%

Lipid Profile of High Tetraplegia (Above C4) in Japan

Okada¹

2008

TOREHJ

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Abstaract: Objective: To investigate whether the risk profile for coronary heart disease (CHD) is more favorable in individuals with high tetraplegia (neurological lesion above C4) than in healthy controls. (Because inactivity has a negative effect on the lipid profile.) Design: Case-control study. Setting: This research was performed in the rehabilitation hospital for the spinal cord injured persons. Participants: 19 healthy male controls (age-, height-, and body weight-matched) and 62 individuals with high tetraplegia (mean age 45.0±17.35 years) with a mean time since injury of 16.9±23.88 months were assessed the information was obtained from the 22 tetraplegics who had returned home from our hospital (all the other 40 left to other hospital), and recorded data on lipid values for comparison. Interventions: Not applicable. Main outcome measures: Total plasma cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) concentrations were measured, and calculated the low-density lipoprotein cholesterol (LDL-C) concentration and the ratios of TC/HDL-C and LDL-C/HDL-C were calculated. Results: Significantly lower concentrations of TC, HDL-C and LDL-C were found in individuals with a SCI. However, no statistically significant difference was found between TC/HDL-C and LDL-C/HDL-C ratios of tetraplegic individuals and healthy controls. In individuals with high tetraplegia who were discharged home, HDL-C was still lower than normal control. Conclusions: Patients with high tetraplegia showed low HDL-C, but the TC/HDL-C and LDL-C/HDL-C ratios were normal.

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Serum lipids during the first year following acute spinal cord injury

Cited by 28 publications

References 13 publications

Challenges, concerns and common problems: physiological consequences of spinal cord injury and microgravity

Challenges, concerns and common problems: physiological consequences of spinal cord injury and microgravity

Early adaptive changes in chronic paraplegic mice: a model to study rapid health degradation after spinal cord injury

Lipid Profile of High Tetraplegia (Above C4) in Japan

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