Serum Lipids in Celiac Children

Ciampolini, Mario; Bini, Stefania

doi:10.1097/00005176-199105000-00008

Cited by 17 publications

(12 citation statements)

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“…10 HDL has also been found to be low among celiac due to decreased Apo-A1 secretion. 31,32 However, in our study despite having predominantly gastrointestinal presentation and total villous atrophy at diagnosis, the mean total cholesterol level and mean HDL level was within normal range. This could possibly be explained by young age of our study population.…”

Section: Discussioncontrasting

confidence: 52%

“…HDL cholesterol is regarded as a potent anti-atherogenic mediator with anti-inflammatory, anti-oxidative and antithrombotic properties. 31 Estimated coronary heart disease risk for each 1mg/dl increase in HDL-C is 2% in men and 3% in women. 34,35 The present study shows that HDL-C levels were significantly increased among the cases after 6 months of GFD (p <0.001).…”

Section: Discussionmentioning

confidence: 99%

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Serum Lipid Profile in Newly Diagnosed Children with Celiac Disease and at Six Months of Treatment with GFD

Deswal¹,

Nabum²,

Dewan³

et al. 2020

IJCMR

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Introduction: Cardiovascular disease is one of the leading causes of death among adult celiacs. Increased risk is attributed to unfavourable cholesterol profile. Studies on lipid profile among celiacs have shown variable results. Effect of gluten free diet (GFD) on cardiovascular risk profile is further controversial. Knowledge among children can help in risk stratification and timely modification of diet if needed. Current study objective was to record the lipid profile among children with celiac and the impact of six months of gluten free diet on it. Material and methods: In this single arm pre and post interventional study, newly diagnosed symptomatic children 1-14 years with Tissue Transglutaminase (tTG) IgA antibody positive and biopsy proven (Marsh 3) celiac were enrolled. Sample size of 31 was calculated as per TC and HDL reference levels. Fasting Lipid profile was evaluated at baseline and at six months of GFD. Children with diabetes, hypothyroidism, nephrotic syndrome, congenital hyperlipidaemia and on drugs causing hyperlipidaemia were excluded. The data analysis was done using Statistical software R and Stata 15.0. Quantitative variables were compared using Paired T test/Wilcoxon test. Qualitative variables were correlated using Chi-Square test/ Fisher's exact test. Results: Median age of children was 8 years (5-10 years). Median age at onset of symptoms was 6 (3.15-8.75) years and median duration of illness prior to diagnosis was 12 (7.5-24) months. 83.87% presented with typical GI symptoms. Mean Total cholesterol (TC) was 131.8±39.7 mg/dl, mean HDL cholesterol was 41.2±12.6 mg/dl, mean Triglycerides was 92.0±35.5mg/dl and mean LDL was 75 ± 32.3 mg/dl at diagnosis. Average increase in HDL after GFD was 13 (4.9 to 21.3) mg/dl. TC/HDL ratio was decreased significantly after GFD {-0.5 (-0.9 to-0.03)}. Conclusion: Children with celiac have a normal lipid profile. GFD for six months increases HDL-C plasma concentration and lowers TC/HDL ratios.

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Serum Lipid Profile in Newly Diagnosed Children with Celiac Disease and at Six Months of Treatment with GFD

Deswal¹,

Nabum²,

Dewan³

et al. 2020

IJCMR

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“…A study in adult patients demonstrated a higher microvascular risk for patients with T1D and CD based on lipid parameters . In 1991, Ciampolini et al analyzed serum lipids in children with CD without T1D: They reported lower high‐density lipoprotein (HDL) cholesterol values in children with CD which increased after adhering to a gluten‐free diet, but also an increase of total cholesterol and low‐density lipoprotein (LDL) cholesterol in young children . Gopee et al reported a slower progression to albuminuria in patients with T1D plus CD compared with a cohort of patients with T1D only, possibly because of a gluten‐free diet.…”

mentioning

confidence: 99%

Vascular risk factors in children, adolescents, and young adults with type 1 diabetes complicated by celiac disease: results from the DPV initiative

et al. 2015

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“…On GFD the lipid profile reverted to normal as consequence of improvement of mucosal damage caused by gluten withdraw. Ciampolini et al[ 29 ] investigated the plasma lipid levels in CD children (45 under and 49 over 3 years of age, at diagnosis) on GFD, and in comparison with children affected by irritable bowel syndrome (IBS) matched for body size, gender, and age. They found that untreated CD children had significantly lower total and high density lipoprotein cholesterol (HDL-C) levels and significantly higher triglyceride concentrations than IBS controls in both age groups.…”

Section: Serum Lipidsmentioning

confidence: 99%

Cardiometabolic risk factors in children with celiac disease on a gluten-free diet

Anania¹,

Pacifico²,

Olivero³

et al. 2017

WJCP

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Celiac disease (CD) is an immune-mediated systemic condition evoked by gluten and related prolamines in genetically predisposed subjects. It is characterised by a variable combination of gluten-dependent clinical symptoms, CD-specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. The only therapy of CD consists of a life-long gluten free diet (GFD). Strict GFD adherence results in full clinical, serological and histological remission, avoiding long-term complications in CD patients. However, this diet is not without problems. Gluten free products have high levels of lipids, sugar and salt to improve food palatability and consistency, and subjects with CD show an excessive consumption of hypercaloric and hyperlipidic foods to compensate dietetic restriction. GFD may therefore have a negative impact on cardiometabolic risk factors such as obesity, serum lipid levels, insulin resistance, metabolic syndrome, and atherosclerosis. In adults, some studies have suggested that GFD have a beneficial effect on cardiovascular profile, whereas others have shown an atherogenic effect of GFD. In children, very few studies are available on the issue. Thus, the aim of the present narrative review was to analyze the current clinical evidence on the impact of GFD on cardiometabolic risk factors in children with CD.

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Serum Lipids in Celiac Children

Cited by 17 publications

References 0 publications

Serum Lipid Profile in Newly Diagnosed Children with Celiac Disease and at Six Months of Treatment with GFD

Serum Lipid Profile in Newly Diagnosed Children with Celiac Disease and at Six Months of Treatment with GFD

Vascular risk factors in children, adolescents, and young adults with type 1 diabetes complicated by celiac disease: results from the DPV initiative

Cardiometabolic risk factors in children with celiac disease on a gluten-free diet

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