Serum lipids modify periodontal infection ‐ C‐reactive protein association

Abstract

This study suggests that the relation of periodontal infection to the systemic inflammatory condition is more complicated than previously presumed. The findings of this study suggest that the possible systemic effect of periodontal infection is dependent on serum lipid composition.

Serum lipids modify periodontal infection – interleukin‐6 association

“…This corresponds to and confirms our earlier findings on the role of HDL and LDL in the association between the number of teeth with deepened periodontal pockets and CRP levels (Haro et al. ).…”

“…Regarding IL-6, the findings are in line with the results of a number of non-experimental and experimental studies where periodontitis and ligatureinduced periodontitis were reported to be associated with systemic inflammation. It should be noted that this finding is by no means unexpected, because IL-6 is known to trigger off CRP secretion in the liver and we have earlier reported a positive association between the number of teeth with deepened periodontal pockets and the CRP level of subjects using the same Health 2000 data (Haro et al 2012). In the stratified analyses, we observed that a systemic inflammatory response was somewhat stronger among those with an unfavourable lipid profile (i.e.…”

“…In line with these observations, we have earlier shown that the number of teeth with deepened (4 mm or deeper) periodontal pockets was associated with the serum CRP level among those with an unfavourable lipid composition, whereas such an association did not exist among those with a favourable lipid composition (Haro et al. ).…”

“…It should be noted that this finding is by no means unexpected, because IL‐6 is known to trigger off CRP secretion in the liver and we have earlier reported a positive association between the number of teeth with deepened periodontal pockets and the CRP level of subjects using the same Health 2000 data (Haro et al. ). In the stratified analyses, we observed that a systemic inflammatory response was somewhat stronger among those with an unfavourable lipid profile (i.e.…”

“…In terms of systemic effects, complete elimination of periodontitis by extractions was found to reduce the level of inflammatory markers more among non-smokers than among smokers (Taylor et al 2006) and non-surgical periodontal therapy was found to decrease the serum levels of TNF-a among obese subjects but not among normoweight subjects (Altay et al 2013). In line with these observations, we have earlier shown that the number of teeth with deepened (4 mm or deeper) periodontal pockets was associated with the serum CRP level among those with an unfavourable lipid composition, whereas such an association did not exist among those with a favourable lipid composition (Haro et al 2012).…”