Serum lipoprotein profile in Algerian patients with celiac disease

Médiène, S.; Hakem, S.; Bard, Jean‐Marie; Medjaoui, I.; Benhamamouch, Soraya; Lebel, P.; Fruchart, Jean Charles; Clavey, Véronique

doi:10.1016/0009-8981(95)06028-1

Cited by 12 publications

(9 citation statements)

References 17 publications

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“…In the current study, patients showed TC and LDL-C levels similar to controls. These findings are in disagreement with the decrease in both parameters previously reported for CD patients[5,51,52]. Patients evaluated in this study also presented lower HDL-C levels.…”

Section: Discussioncontrasting

confidence: 99%

Markers of inflammation and cardiovascular disease in recently diagnosed celiac disease patients

Tetzlaff¹,

Meroño²,

Menafra³

et al. 2017

WJC

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AIMTo evaluate novel risk factors and biomarkers of cardiovascular disease in celiac disease (CD) patients compared with healthy controls.METHODSTwenty adult patients with recent diagnosis of CD and 20 sex, age and body mass index-matched healthy controls were recruited during a period of 12 mo. Indicators of carbohydrate metabolism, hematological parameters and high sensitive C reactive protein were determined. Moreover, lipoprotein metabolism was also explored through evaluation of the lipid profile and the activity of cholesteryl ester transfer protein and lipoprotein associated phospholipase A2, which is also considered a specific marker of vascular inflammation. The protocol was approved by the Ethic Committee from School of Pharmacy and Biochemistry, University of Buenos Aires and from Buenos Aires Italian Hospital, Buenos Aires, Argentina.RESULTSRegarding the indicators of insulin resistance, CD patients showed higher plasma insulin levels [7.2 (5.0-11.3) mU/L vs 4.6 (2.6-6.7) mU/L, P < 0.05], increased Homeostasis Model Assessment-Insulin Resistance [1.45 (1.04-2.24) vs 1.00 (0.51-1.45), P < 0.05] and lower Quantitative Sensitive Check index [0.33 (0.28-0.40) vs 0.42 (0.34-0.65), P < 0.05] indexes. Folic acid concentration [5.4 (4.4-7.9) ng/mL vs 12.2 (8.0-14.2) ng/mL, P < 0.01] resulted to be lower and High-sensitivity C reactive protein levels higher (4.21 ± 6.47 mg/L vs 0.98 ± 1.13 mg/L, P < 0.01) in the patient group. With respect to the lipoprotein profile, CD patients showed lower high density lipoprotein-cholesterol (HDL-C) (45 ± 15 mg/dL vs 57 ± 17 mg/dL, P < 0.05) and apo A-I (130 ± 31 mg/dL vs 155 ± 29 mg/dL, P < 0.05) levels, as well as higher total cholesterol/HDL-C [4.19 (3.11-5.00) vs 3.52 (2.84-4.08), P < 0.05] and apo B/apo A-I (0.75 ± 0.25 vs 0.55 ± 0.16, P < 0.05) ratios in comparison with control subjects. No statistically significant differences were detected in lipoprotein-associated lipid transfer protein and enzymes.CONCLUSIONThe presence and interaction of the detected alterations in patients with CD, would constitute a risk factor for the development of atherosclerotic cardiovascular disease.

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Section: Discussioncontrasting

confidence: 99%

Markers of inflammation and cardiovascular disease in recently diagnosed celiac disease patients

Tetzlaff¹,

Meroño²,

Menafra³

et al. 2017

WJC

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“…Recent screening studies in general populations come almost exclusively from European countries and the USA [1][2][3][4][5][6][7]. On the basis of data from a series of clinically diagnosed CD, the scientific community has generally considered the disease to be frequent in the North African population [11][12][13][14][15]. In Africa, the only screening study in the general population involved a group of refugee children from Western Sahara and stated a prevalence averaging 1/18 [16].…”

Section: Discussionmentioning

confidence: 99%

“…The international scientific community generally considers that CD is frequent in North Africa, but few epidemiological data are available and this belief is based on a large series of CD, clinically diagnosed and reported in North Africa [11][12][13]. Besides, it has been reported that CD is common among children born to North African parents who have emigrated to France and Italy [14,15].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of celiac disease in Tunisia: mass-screening study in schoolchildren

Hariz¹,

Kallel-Sellami

Kallel³

et al. 2007

European Journal of Gastroenterology & Hepatology

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“…Against this background, Médiène et al[ 32 ], who compared 46 CD adult and pediatric patients and 155 control subjects, found that untreated CD patients had decreased cholesterol, phospholipid and apo-A-I levels and elevated triglycerides. However, they did not find a return towards normal lipid profile following GFD.…”

Section: Serum Lipidsmentioning

confidence: 99%

Cardiometabolic risk factors in children with celiac disease on a gluten-free diet

Anania¹,

Pacifico²,

Olivero³

et al. 2017

WJCP

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Celiac disease (CD) is an immune-mediated systemic condition evoked by gluten and related prolamines in genetically predisposed subjects. It is characterised by a variable combination of gluten-dependent clinical symptoms, CD-specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. The only therapy of CD consists of a life-long gluten free diet (GFD). Strict GFD adherence results in full clinical, serological and histological remission, avoiding long-term complications in CD patients. However, this diet is not without problems. Gluten free products have high levels of lipids, sugar and salt to improve food palatability and consistency, and subjects with CD show an excessive consumption of hypercaloric and hyperlipidic foods to compensate dietetic restriction. GFD may therefore have a negative impact on cardiometabolic risk factors such as obesity, serum lipid levels, insulin resistance, metabolic syndrome, and atherosclerosis. In adults, some studies have suggested that GFD have a beneficial effect on cardiovascular profile, whereas others have shown an atherogenic effect of GFD. In children, very few studies are available on the issue. Thus, the aim of the present narrative review was to analyze the current clinical evidence on the impact of GFD on cardiometabolic risk factors in children with CD.

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Serum lipoprotein profile in Algerian patients with celiac disease

Cited by 12 publications

References 17 publications

Markers of inflammation and cardiovascular disease in recently diagnosed celiac disease patients

Markers of inflammation and cardiovascular disease in recently diagnosed celiac disease patients

Prevalence of celiac disease in Tunisia: mass-screening study in schoolchildren

Cardiometabolic risk factors in children with celiac disease on a gluten-free diet

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