Serum lipoproteins and cancer

Muntoni, Sandro; Atzori, Luigi; Mereu, Roberto; Satta, G.; Macis, Maria Doloretta; Congia, Mauro; Tedde, Andrea; Desogus, A

doi:10.1016/j.numecd.2008.06.002

Cited by 76 publications

(68 citation statements)

References 29 publications

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“…Various types of cancer affect the lipid metabolism in humans. [1][2][3] Hepatoma also induces an abnormal serum lipid metabolism in humans 4,5) and animals. 6) Rats subcutaneously implanted with an ascites hepatoma cell line of AH109A cells have shown hyperlipidemia [7][8][9][10][11][12][13][14] with a notable decrease in the high-density lipoprotein (HDL) fraction and an enormous increase in the fraction of very-low-density lipoprotein plus low-density lipoprotein (VLDL þ LDL) during growth of the hepatoma.…”

mentioning

confidence: 99%

Comparison of the Effects on Lipid Metabolism of Dietary Methionine and Cystine between Hepatoma-Bearing and Normal Rats

Kawasaki

Miura

Funabiki

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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confidence: 99%

Comparison of the Effects on Lipid Metabolism of Dietary Methionine and Cystine between Hepatoma-Bearing and Normal Rats

Kawasaki

Miura

Funabiki

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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“…Fatty acid oxidation was estimated using liver slices ( 30 ). Liver slices weighing 200 mg were placed in 2 mL of Krebs-Ringer phosphate buffer (pH ϭ 7.4) containing 37 kBq/ mol/assay of [1][2][3][4][5][6][7][8][9][10][11][12][13][14] C]palmitic acid (original specific radioactivity ϭ 310 MBq/mmol, NEN Research Products). Each tube was gassed with 100% O 2 , connected with a rubber tube (18 mm in inside diameter) to a counting vial which held circular filter paper (No.…”

Section: Animals and Dietsmentioning

confidence: 99%

“…Various cancers affect serum lipoprotein profiles in humans (1)(2)(3)(4). Hepatoma also induces an abnormal serum lipid metabolism in humans ( 5 ) and animals ( 6 ).…”

mentioning

confidence: 99%

Effects of Simultaneous Dietary Fish Oil Ingestion and Sulfur Amino Acid Supplementation on the Lipid Metabolism in Hepatoma-Bearing Rats with Hyperlipidemia

Kawasaki

Miura

Funabiki

et al. 2010

J Nutr Sci Vitaminol

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SummaryThe effects of simultaneous dietary fish oil ingestion and sulfur amino acid ( Lmethionine and L -cystine) supplementation on serum lipid concentrations and various parameters related to the lipid metabolism were studied in Donryu rats subcutaneously implanted with an ascites hepatoma cell line, AH109A. A diet containing 10% fish oil was found to reduce serum triglyceride, total cholesterol, (very-low-density lipoprotein plus lowdensity lipoprotein)-cholesterol, phospholipid and nonesterified fatty acid (NEFA) concentrations in these animals, and dietary supplementation of 1.2% L -methionine and L -cystine also suppressed these serum lipid concentrations. Hepatic fatty acid synthesis and the availability of serum NEFA were decreased, and epididymal adipose tissue lipoprotein lipase (LPL) activity was elevated by dietary fish oil, while LPL activity in various tissues and hepatic fatty acid oxidation were increased by dietary sulfur amino acids, resulting in a reduction in the serum triglyceride concentration by dietary fish oil and sulfur amino acids, respectively. Dietary fish oil suppressed the hepatoma-induced increase in cholesterogenesis in the host liver, and dietary methionine and cystine enhanced bile acid excretion into feces, which were the causes of the hypocholesterolemic effect. In these serum lipid concentrations, there were significant effects of fish oil ingestion and sulfur amino acid supplementation, but no significant interaction between these two factors was seen. These results indicate that dietary fish oil and sulfur amino acid, L -methionine and L -cystine, have hypolipidemic effects in cancer-related hyperlipidemia, and that the effects of these two factors on the decrease in these serum lipid concentrations are additive; these two factors may affect the lipid metabolism via different pathways and mechanisms. Key Words dietary fish oil, dietary sulfur amino acid, hepatoma, hyperlipidemia, rats Various cancers affect serum lipoprotein profiles in humans ( 1-4 ). Hepatoma also induces an abnormal serum lipid metabolism in humans ( 5 ) and animals ( 6 ). Rats subcutaneously implanted with an ascites hepatoma cell line of AH109A cells show hyperlipidemia ( 7 ) with a notable decrease in high-density lipoprotein (HDL) fraction and an enormous increase in the very-low-density lipoprotein plus low-density lipoprotein (VLDL ϩ LDL) fraction during growth of the hepatoma. AH109A-bearing rats thus provide an endogenously hyperlipidemic animal model that is quite distinct from the cholesterol-loaded animals widely used as an exogenously hyperlipidemic model.Dietary fish oil, which is rich in n -3 polyunsaturated fatty acids, is well known to suppress concentrations of serum lipids such as triglyceride, cholesterol, phospholipid and nonesterified fatty acid (NEFA) in normal rats ( 8 , 9 ), rats with cancer-related hyperlipidemia ( 10 ), non-insulin dependent diabetes mellitus mice ( 11 ), and hyperlipidemic patients ( 12 ). Dietary supplementation of amino acids and their derivatives have been ...

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“…Various types of cancers affect lipid metabolism (Barclay et al 1970;Muntoni et al 2009;Nydegger and Butler 1972;Qadir and Malik 2008). Previous studies have reported that Donryu rats subcutaneously implanted with AH109A hepatoma cells show hyperlipidemia (Irikura et al 1985) with high concentrations of serum triglyceride and nonesterified fatty acid (NEFA) as well as suppression of lipoprotein lipase (LPL) and elevation of hormone-sensitive lipase (HSL) activities in the epididymal adipose tissue during the growth of the hepatoma (Kawasaki et al 2004(Kawasaki et al , 2010.…”

Section: Introductionmentioning

confidence: 99%

Effects of sulfur amino acids, l-methionine, l-cystine and l-cysteine on lipoprotein lipase and hormone-sensitive lipase in differentiated mouse 3T3-L1 adipocytes

2010

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Rats subcutaneously implanted with AH109A hepatoma cells show hyperlipidemia with high concentrations of serum triglyceride and nonesterified fatty acid, suppression of lipoprotein lipase (LPL), and elevation of hormone-sensitive lipase (HSL) activities during the growth of the hepatoma. Supplementation of the diet with sulfur amino acids such as L-methionine (Met) and L-cystine (Cys) improved hyperlipidemia by restoring LPL and HSL activities. In the present study, we have attempted to examine the effects of sulfur amino acids on the activity and mRNA level of LPL and the activity of HSL using 3T3-L1 cells, which are known to differentiate to adipocytes. The adipocytes were incubated with various concentrations of Met, Cys or L-cysteine (CysH) in the absence or presence of tumor necrosis factor-a (TNF-a). LPL activity was suppressed by TNF-a. In the absence of TNF-a, Met, Cys and CysH did not change the LPL activity. In the presence of TNF-a, Met and Cys significantly increased the LPL activity, and Met also enhanced the LPL mRNA level. HSL activity was also suppressed by TNF-a. In the absence of TNF-a, Met enhanced the HSL activity. In the presence of TNF-a, Met, Cys and CysH suppressed the HSL activity. Sulfur amino acids such as Met, Cys and CysH affected the LPL activity, mRNA level, and HSL activity in 3T3-L1 adipocytes. Some of these effects of sulfur amino acids were different between LPL and HSL, between the absence and the presence of TNF-a, and between 3T3-L1 adipocytes and the adipose tissue from rats.

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Serum lipoproteins and cancer

Cited by 76 publications

References 29 publications

Comparison of the Effects on Lipid Metabolism of Dietary Methionine and Cystine between Hepatoma-Bearing and Normal Rats

Comparison of the Effects on Lipid Metabolism of Dietary Methionine and Cystine between Hepatoma-Bearing and Normal Rats

Effects of Simultaneous Dietary Fish Oil Ingestion and Sulfur Amino Acid Supplementation on the Lipid Metabolism in Hepatoma-Bearing Rats with Hyperlipidemia

Effects of sulfur amino acids, l-methionine, l-cystine and l-cysteine on lipoprotein lipase and hormone-sensitive lipase in differentiated mouse 3T3-L1 adipocytes

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