Serum lithium levels and psychosocial function in patients with bipolar I disorder

Da, Solomon; Wr, Ristow; Mb, Keller; Jm, Kane; Aj, Gelenberg; Jf, Rosenbaum; Mg, Warshaw

doi:10.1176/ajp.153.10.1301

Cited by 55 publications

(6 citation statements)

References 18 publications

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“…It is known that patients with standard serum lithium levels have better psychosocial functioning than patients with low serum lithium levels. This effect is partly due to the prevention of episodes (34). In our study, the reason we did not find any relationships between serum drug levels and levels of functioning may be due to the small number of cases.…”

Section: Factors Affecting the Patients' Levels Of Functioningcontrasting

confidence: 48%

“…It has been shown that pharmacological treatment, especially using second-generation antipsychotic drugs, has an adverse effect on cognitive functions in patients with BD (33). It has been reported that lithium treatment increases the quality of life by preventing recurrence of episodes of the disorder (34). It has been reported that second generation antipsychotic drugs used in patients with BD in remission have negative effects on psychosocial functioning (28).…”

Section: Factors Affecting the Patients' Levels Of Functioningmentioning

confidence: 99%

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Evaluation of Functioning Levels and Associated Factors in Patients with Remission in Bipolar Disorder

Hacımusalar

Dogan²

2019

Archives of Neuropsychiatry

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Introduction: The course of bipolar disorder (BD) is characterized by relapse and remission periods. Although the symptoms show a significant and sometimes almost complete improvement during remission, the patients' functioning levels may be lower compared to the premorbid period. This study aimed to compare the functional levels between patients with BD during remission period and healthy controls and to evaluate the factors related to the functional status of the patients. Methods: In this cross-sectional study, functioning levels of the BD-I patients, who were in remission for three months or longer, were compared with those of the healthy controls. Young Mania Rating Scale and Hamilton Depression Rating Scale were used to determine remission status, and Bipolar Disorder Functioning Questionnaire (BDFQ) was used to determine the level of functioning. Results: The study included 165 BD-I patients during remission and 63 healthy controls. The BDFQ scores of the patients including intellectual functioning, sexual functioning, feeling of stigmatization, introversion, relationships with friends, participation in social activities, daily activities and hobbies, and taking initiative were found to be statistically significantly lower than those of the controls. When the functioning comparisons were carried out within the patients considering the drugs they were using, the functioning levels including domestic functioning and introversion domains were found to be significantly impaired in those who use at least one antipsychotic in addition to the mood stabilizers than in those who use only mood stabilizers. Conclusion: In BD, the impairments within multiple functioning domains are observed even during remission periods. Besides targeting remission through pharmacological treatment, psychosocial interventions for functioning are also important in the treatment of these patients.

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Section: Factors Affecting the Patients' Levels Of Functioningcontrasting

confidence: 48%

Section: Factors Affecting the Patients' Levels Of Functioningmentioning

confidence: 99%

Evaluation of Functioning Levels and Associated Factors in Patients with Remission in Bipolar Disorder

Hacımusalar

Dogan²

2019

Archives of Neuropsychiatry

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“…Demographic variables, such as older age [120], male sex [121, 122] and low socio-economic status [17, 18, 123], may also be considered as variables that influence the functioning of bipolar patients, although these results have yet to be sufficiently replicated. Other aspects could be environmental factors, such as social support [9, 31, 32] or life events [33].…”

Section: Resultsmentioning

confidence: 99%

“…Some drugs appear to show several advantages with respect to the probability of being employed or paid for work [36, 127, 128]. Moreover, patients receiving lithium doses that achieved therapeutic serum levels had better psychosocial functioning than those receiving doses that achieved low serum levels [123], so probably treatment adherence plays an important role for functioning.…”

Section: Resultsmentioning

confidence: 99%

Functioning and Disability in Bipolar Disorder: An Extensive Review

Sanchez-Moreno

Martínez-Àran

Tabarés‐Seisdedos

et al. 2009

Psychother Psychosom

366

282

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Background: Bipolar disorder has generally been regarded as having a better functional outcome than schizophrenia. However, studies have suggested low functioning in bipolar patients even when they are in clinical remission. Our aim was to determine the degree of functioning and disability in bipolar patients. Secondly, we reviewed factors potentially associated with the low functioning of bipolar patients. Method: The authors conducted an extensive Medline and Pubmed search of the published literature from 1980 up to December 2007, using a variety of search terms to find relevant articles. Bibliographies of retrieved papers were further analysed for publications of interest. Articles that reported clinically significant findings on functioning and disability, and research reports were reviewed in detail. Results: From these articles, we determined that bipolar disorder is associated with significant impairment in work, family and social life, beyond the acute phases of the illness. The aspects that appear to increase the risk of low functioning and disability in bipolar patients are mainly subsyndromal symptoms and neurocognitive impairment, among others. Conclusions: Suitable pharmacological and psychological interventions may improve the level of functioning and reduce the disability in bipolar patients. Potential targets to be considered for intervention should be residual symptoms, comorbid conditions and neurocognitive deficits. Further research is required to better identify the factors that best predict functioning in bipolar patients.

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“…Maintenance therapy reduces the frequency of manic episodes and diminishes the intensity of those episodes which may occur .Typical symptoms of mania include pressure of speech, motor hyperactivity, reduced need for sleep, flight of ideas, grandiosity, elation, poor judgment, aggressiveness, and possibly hostility. When given to a patient experiencing a manic episode, lithium may produce a normalization of symptomatology within 1 to 3 weeks [6] Spermatozoa were first described by Leeuwenhoek in the 17th century but it was not until 1928 that the sperm count was found to be associated with fertility potential [7]. The mammalian sperm cell consists of a head, a midpiece and a tail.…”

Section: Introductionmentioning

confidence: 99%

In vitro Effects of lithium on Human Sperm Motility

2015

International Institute of Chemical, Biological &Amp; Environmental Engineering June 5-6, 2015 Istanbul (Turkey)

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Lithium has a significant impact in reducing the symptoms of bipolar mania but in long periods of use with therapeutic doses can cause several disorders in various organs including the reproductive system. In this study on the sperm concentration and motility has been examined. Nowadays, infertility coming from incapability of male system, particularly from sperm disorder is very common. Some types of sperm disorders may result from the medications used by human. The main aim of this was to investigate the in vitro effects of lithium on human sperm motility. Different concentration of lithium was prepared and human semen samples were exposed to lithium solution and the sperm count and motility was examined using routine laboratory method. The results showed that lithium caused decreased motility of sperms with dose dependent pattern, i.e., the more concentarion of lithium applied, the more decrease in sperm motility occurred. In conclusion, lithium has a potential to impair sperm count and motility, so, this aspect of the drug should be considered in patients using lithium.

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Serum lithium levels and psychosocial function in patients with bipolar I disorder

Abstract: For patients with bipolar I disorder, standard serum lithium levels may enhance psychosocial functioning, above and beyond the effects of relapse prevention.

Cited by 55 publications

References 18 publications

Evaluation of Functioning Levels and Associated Factors in Patients with Remission in Bipolar Disorder

Evaluation of Functioning Levels and Associated Factors in Patients with Remission in Bipolar Disorder

Functioning and Disability in Bipolar Disorder: An Extensive Review

In vitro Effects of lithium on Human Sperm Motility

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