Serum <i>Helicobacter Pylori</i> IgG Titers are Predictive of <i>H. pylori</i> Infection Status

Abstract

: The aim of the present study was to test the hypothesis that a novel serum Helicobacter pylori IgG kit derived from Japanese H. pylori strains, namely the Sphere Light H. pylori IgG J kit SL-HP J , would enable discrimination of H. pylori infection status. In total, 273 patients were enrolled in the study and underwent endoscopic examination at Inui Clinic of Internal Medicine. Serum H. pylori IgG titers were measured using the SL-HP J kit. Current H. pylori infection was de ned as positivity in at least one H. pylori test rapid urease test, urease breath test, monoclonal stool antigen test, or histology , excluding serology. Naïve H. pylori infection was de ned as negativity in all H. pylori tests and chronic atrophic gastritis CAG , as determined by endoscopy. Previous H. pylori infection was de ned as negativity for all H. pylori tests despite the presence of CAG. After testing, 134 patients were deemed to be naïve to H. pylori infection, 83 patients were diagnosed with current H. pylori infection, and the remaining 56 patients were diagnosed with previous H. pylori infection. Median quartile deviation titers in patients with naïve, previous, and current H. pylori infection were 0.8 0.4, 2.1 2.3, and 24.8 22.7 U / ml, respectively. The receiver operating characteristic ROC curve for naïve and previous H. pylori infection to classify naïve H. pylori infection showed an area under the curve AUC of 0.910, with 83 sensitivity and 82 speci city for a cut-off level of 1.6 U / ml ; the ROC curve for previous and current H. pylori infection to classify current H. pylori infection had an AUC of 0.969, with 96 sensitivity and 88 speci city for a cut-off level of ≥ 3.3 U / ml. The present study shows that serum H. pylori IgG titers may be used to determine H. pylori infection status.

Pepsinogen and Serum IgG Detection Is a Valuable Diagnostic Method for Helicobacter pylori Infection in a Low-Prevalence Country: A Report from Sri Lanka

“…Among serology-positive subjects, H. pylori in four subjects could not be detected by histology and culture, but histological examination showed moderate atrophy and metaplasia. This may indicate past infections [39]. A previous study reported that in patients with a high titer of anti-H. pylori IgG, 17.5% of them were previously infected, and the infection had been eradicated [40].…”