Serum lutein concentrations in healthy term infants fed human milk or infant formula with lutein

Bettler, Jodi; Zimmer, Jacques; Neuringer, Martha; DeRusso, Patricia A.

doi:10.1007/s00394-009-0047-5

Cited by 93 publications

(91 citation statements)

References 24 publications

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“…In comparison, mean plasma lycopene in term (Figure 1). These results confirm a recent observation 20 that lutein content in formula needs to be Bfour times greater than in HM lutein content in order to achieve similar plasma lutein levels. There were no differences between the two study groups in growth.…”

Section: Resultssupporting

confidence: 91%

“…31 Recently, it has been suggested that carotenoid fortification of term infant formula at the high end of the range of HM content might maximize functional effects without posing safety risk. 20,32 Our findings demonstrate safety and potential health benefits in a large group of preterm and extremely preterm neonates. This is the first randomized, controlled, double-blind, parallel, multicenter study to assess the effect of feeding a carotenoidsupplemented diet to preterm infants.…”

Section: Discussionmentioning

confidence: 62%

“…Plasma carotenoid concentrations significantly decline in formula-fed infants immediately following birth compared with their breast-fed counterparts. [17][18][19] Recently, several small studies have approached issues of carotenoid bioavailability 20,21 and putative anti-oxidant effects 16 in preterm newborns. We report the first comprehensive, randomized controlled trial designed to assess feasibility and potential benefits of supplementing preterm infant formulas with the carotenoids lutein, lycopene and b-carotene.…”

Section: Introductionmentioning

confidence: 99%

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Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants

et al. 2011

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Objective: Dietary carotenoids (lutein, lycopene and b-carotene) may be important in preventing or ameliorating prematurity complications. Little is known about carotenoid status or effects of supplementation.Study Design: This randomized controlled multicenter trial compared plasma carotenoid levels among preterm infants (n ¼ 203, <33 weeks gestational age) fed diets with and without added lutein, lycopene and b-carotene with human milk (HM)-fed term infants. We assessed safety and health.Result: Plasma carotenoid levels were higher in the supplemented group at all time points (P<0.0001) and were similar to those of term HM-fed infants. Supplemented infants had lower plasma C-reactive protein (P<0.001). Plasma lutein levels correlated with the full field electroretinogram-saturated response amplitude in rod photoreceptors (r ¼ 0.361, P ¼ 0.05). The supplemented group also showed greater rod photoreceptor sensitivity (least squares means 6.1 vs 4.1; P<0.05). Conclusion:Carotenoid supplementation for preterm infants raises plasma concentrations to those observed in HM-fed term infants. Carotenoid supplementation may decrease inflammation. Our results point to protective effects of lutein on preterm retina health and maturation.

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Section: Resultssupporting

confidence: 91%

Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

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Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants

et al. 2011

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“…The most important ones are β-carotene and lycopene. Lutein concentrations in human milk range from approximately 3-237 mg/L (Bettler et al, 2010;Canfield et al, 2003;Jewell et al, 2004;Tacken et al, 2009). Taken together lutein and zeaxanthin account for 28% of total (Song et al, 2012 In colostrum the carotenoid pattern resembled those of plasma and the low-density lipoprotein fraction.…”

Section: The Role Of Lutein On Infant Nutritionmentioning

confidence: 99%

Why lutein is important for the eye and the brain

Ramírez

2015

OCL

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-Lutein and zeaxanthin are carotenoids that accumulate in the macula. The macula is a yellow spot near the center of the retina that is responsible of high resolution vision. Macular pigment acts as a natural blue light filter and protects the eye from damage. Macular pigment optical density (MPOD) increases with lutein administration and is related to visual function and to the prevention of age-related macular degeneration. MOPD can be measured noninvasively and has been related to better cognitive performance. Moreover, compositional analyses of centenarian brains have shown that lutein is the main carotenoid in the brain although not in plasma, indicating a preferential accumulation in neural tissues, and that carotenoids status is correlated with some functional outcomes. Carotenoids are present in human milk with higher concentration in colostrum than in transitional and mature milk. Formula fed-infants have less plasma lutein concentration than breast fed infants. Analyses of brain from infants who died during the first year of life showed that lutein is also the predominant carotenoid of brain. Studies in non-human primates revealed that carotenoids are determinant in the formation of the retinal epithelia. In vitro studies showed that lutein stimulates the differentiation of human stem cells to neural progenitor cells. All this findings together, mostly the presence of lutein in breast milk, plasma concentration in breast-fed infants vs. formula fed infants, preferential accumulation in the brain and evidences of influence on the retina and the functionality of the brain signal the importance of the role of lutein and zeaxanthin on visual maturation and brain development.Keywords: Lutein / zeaxanthin / brain / infant / nutrition Résumé -Importance de la lutéine pour l'oeil et le cerveau. La lutéine et la zéaxanthine sont des caroténoïdes qui s'accumulent dans la macula. La macula est une tache jaune, située près du centre de la rétine, qui est responsable de la vision fine. Le pigment maculaire agit comme un filtre naturel de la lumière bleue nocive et protège l'oeil contre d'éventuels dommages. La densité optique du pigment maculaire (ou MPOD, acronyme de Macular pigment optical density) augmente avec l'administration de lutéine et est liée à la qualité de la fonction visuelle et à la prévention de la dégénérescence maculaire liée à l'âge. La MOPD peut être mesurée de manière non invasive et a été associée à de meilleures performances cognitives. En outre, les analyses de composition de cerveaux de centenaires ont montré que la lutéine est le caroténoïde principal du cerveau mais pas du plasma, ce qui indique une accumulation préférentielle dans les tissus neuronaux et que le statut en caroténoïdes est corrélé avec quelques données fonctionnelles. Les caroténoïdes sont présents dans le lait maternel avec une concentration plus élevée dans le colostrum que dans lait de transition ou mature. Les enfants nourris avec des formules infantiles (végétales) présentent des diminutions de concentrations...

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“…As inúmeras vantagens do aleitamento materno são conhecidas e apontadas na literatura atual [1][2][3][4][5] . Os nutrientes contidos no leite humano são especialmente adequados ao metabolismo da criança, nos seus aspectos quantitativo e qualitativo 6 .…”

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Fatores Associados ao Desmame Precoce em Mães Assistidas por Serviços de Puericultura de Florianópolis/SC

Giuliani¹

2012

Pesqui. bras. odontopediatria clín. integr.

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Objetivo: identificar a prevalência do desmame precoce (aleitamento materno exclusivo <6 meses) entre mães de crianças de seis a 12 meses de idade, em acompanhamento de puericultura no Hospital Universitário da Universidade Federal de Santa Catarina (HU -UFSC) e na Unidade de Saúde do Saco Grande II (USSGII) em Florianópolis/SC e verificar sua associação com variáveis maternas e do lactente. Método: estudo transversal de características descritivas e analíticas, realizado a partir de entrevistas aplicadas a 200 mães que realizaram consultas de puericultura nestas duas unidades de serviço público de saúde de Florianópolis, entre janeiro e abril de 2005. Utilizou-se o teste exato de Fisher ou qui-quadrado para análise univariada, e as variáveis que apresentaram p<0,20 foram incluídas num modelo de regressão logística múltipla para testar a independência entre elas, considerando estatisticamente significativo um valor de p≤0,05. Resultados: o aleitamento materno (AM) foi realizado por 196 (98%) mulheres e o desmame foi precoce em 160 (81,6%) delas. As variáveis: mãe ter até 26 anos de idade (OR: 2,9; 95% IC: 1,2-6,9; p=0,015), realizar pré-natal na USSG II (OR: 3,3; 95% IC: 1,1-9,5; p=0,029), o bebê não mamar no peito na primeira hora de vida (OR: 3,6; 95% IC: 1,4-9,5; p=0,008) bem como, o trabalho materno nos primeiros seis meses após o parto (OR: 6,0; 95% IC: 2,3-15,8; p<0,001), mostraram-se associadas ao início do desmame precoce independentemente das outras variáveis estudadas. Conclusão: a taxa de amamentação exclusiva na amostra estudada está aquém do preconizado pela Organização Mundial da Saúde. Houve associação, independentemente de outras variáveis, entre o desmame precoce com trabalho e idade maternos, local de pré-natal e tempo decorrido para a primeira mamada. Aleitamento materno; Desmame; Determinantes epidemiológicos; Puericultura.Objective: To identify the prevalence of the early weaning (exclusive breast-feeding <6months), in mothers of children aged 6 to 12 months of age, in monitoring of child care at Hospital Universitário da Universidade Federal de Santa Catarina (HU-UFSC) and the Unidade de Saúde do Saco Grande II (USSGII) in the city of Florianopolis/SC and to determined its association with maternal and infant variables. Method: The transversal study of descriptive and analytical characteristics was conducted through interviews guided by a questionnaire answered by 200 mothers who had routine visits in these two units of public health in Florianopolis, between january and april 2005. We used Fisher's exact test or chi-square test for univariate analysis and variables with p<0.20 were included in a multiple logistic regression model to test the independence between them, considering statistically significant p value ≤0.05. Results: The breastfeeding (BF) was accomplished by 98% of women and the weaning was early in 81.6% of cases. The variables, mother has until 26 years of age (OR: 2,9; 95% IC: 1,2-6,9; p=0,015), conduct antenatal in USSG II (OR: 3,3; 95% IC: 1,1-9,5; p=0,029), the baby not ...

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Serum lutein concentrations in healthy term infants fed human milk or infant formula with lutein

Cited by 93 publications

References 24 publications

Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants

Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants

Why lutein is important for the eye and the brain

Fatores Associados ao Desmame Precoce em Mães Assistidas por Serviços de Puericultura de Florianópolis/SC

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