Serum luteinising hormone, testosterone and total cholesterol levels, libido and testicular histomorphology of male West African Dwarf goats orally or subcutaneously treated with monosodium l-glutamate

Ochiogu, Izuchukwu S.; Ogwu, D.; Uchendu, C. N.; Okoye, Chidozie Nwabuisi; Ihedioha, John Ikechukwu; Mbegbu, Edmund Chidiebere

doi:10.17221/8177-vetmed

Cited by 8 publications

(11 citation statements)

References 19 publications

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“…The absence of any obvious testicular histological lesions in all the groups in this study is in agreement with the reports of Igwebuike et al (2011) and Ochiogu et al (2015a) in rats, and Ochiogu et al (2015b) in goats. They used doses similar to the ones used in this study and they opined that MSG treatment may have impacted on testosterone production through its disruption of the hypothalamic-pituitary-testis regulatory axis, and not through any direct effect on testicular structure.…”

Section: Discussionsupporting

confidence: 93%

“…The significant lowering of the serum total cholesterol by MSG administration on Day 28 in this present study is corroborated by the reports of Bazzano et al (1970), Ochiogu et al (2015a) and Ochiogu et al (2015b) on studies with gerbils, rats and goats, respectively. However, it is not clear what effect this lowering of serum cholesterol exerted on testosterone concentrations in this study, as it is known that cholesterol is a precursor for testosterone biosynthesis (Hinshelwood 1998).…”

Section: Discussionsupporting

confidence: 92%

“…This lowering effect on the LH concentration could be attributed to the reported lesions MSG produces in the arcuate nucleus of the hypothalamus which secretes gonadotrophin-releasing hormone (GnRH) (Tafelski and Lamperti 1997;Ochiogu et al 2015a). The GnRH controls the biosynthesis and secretion of LH by the anterior pituitary (Norris 1997;Ochiogu et al 2015a;Ochiogu et al 2015b).…”

Section: Discussionmentioning

confidence: 99%

“…It is manufactured and marketed as a flavouring agent under various trade names such as Ac'cent ® , Aji-No-Moto ® , Vestin ® , Vedan ® and A-one ® . There are anecdotal reports that MSG is used to 'knock out' libido in male goats (Igwebuike et al 2011;Ochiogu et al 2014;Ochiogu et al 2015a; doi: 10.17221/8765-VETMED Ochiogu et al 2015b). Olney (1993) also reported the use of MSG as a bleaching agent in Nigeria.…”

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confidence: 99%

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The effects of monosodium l-glutamate administration on the reproduction and serum biochemistry of adult male rabbits

Okoye¹,

Ochiogu²,

Onah³

2016

Vet. Med. - Czech

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ABSTRACT:In this study the effects of monosodium l-glutamate (MSG) administration on the reproductive parameters and serum biochemistry of male rabbits were investigated. Sixteen mature male New Zealand mixed-breed of rabbits (Oryctolagus species) weighing 1.1-1.65 kg were used for this study. They were randomised into four groups of four rabbits each. Group A which served as the untreated control, received only distilled water while Groups B, C and D which were the treated groups, received 0.25 g/kg, 0.5 g/kg and 1 g/kg body weight of MSG from a 40% MSG stock solution. The MSG was administered to the rabbits by oral gavage every forty-eight hours for a period of eight weeks. Serum levels of luteinising hormone (LH), testosterone, total cholesterol and total protein, and activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were evaluated on Days 14, 28 and 56 of MSG administration. Results showed that when compared to the untreated group (Group A), on Day 56 of MSG administration the mean serum levels of both LH and testosterone were significantly (P < 0.05) lower in Group D that received 1 g/kg body weight MSG, while the serum cholesterol levels of Group C rabbits that received 0.5 g/kg body weight MSG was significantly (P < 0.05) lower on Day 28 of MSG administration. The mean serum ALT activity of Groups B and C rabbits were significantly (P < 0.05) lower on Day 56 of MSG administration, while the mean serum AST activity of the Group D rabbits was significantly (P < 0.05) higher on Day 14 of MSG administration. There were no significant (P > 0.05) variations in the mean serum total protein between the groups. Testicular histomorphology revealed that MSG administration did not affect the testes of the rabbits as there was no obvious testicular histopathology. It was concluded that administration of MSG to male rabbits significantly lowered serum LH, testosterone and cholesterol levels and serum ALT activity without affecting testicular histomorphology.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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The effects of monosodium l-glutamate administration on the reproduction and serum biochemistry of adult male rabbits

Okoye¹,

Ochiogu²,

Onah³

2016

Vet. Med. - Czech

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“…Therefore, the decreased level of serum TST recorded may be attributed to the low LH levels. Our findings are corroborated by the studies of Bazzano et al [42] and Ochiogu et al [43] who reported low serum TCHOL, LH and TST following monosodium L-glutamate administration in humans and West African Dwarf goats respectively. Also, Manjunath et al [44] reported low TST and LH levels in streptozotocin-induced diabetic rats.…”

Section: Discussionsupporting

confidence: 92%

Effect of edible camphor administrations on levels of steroid and thyroid hormones in male wistar rats

Somade¹,

Ugbaja²,

Adebayo³

2017

Am J Res Med Sci

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Background: Edible camphor (EC) is one of the ingredients in the preparation of local infusion for the management and treatment of pile, back pain, and erectile dysfunction, which are practices commonly in the south-western part of Nigeria. Conversely, 2 and 4 g/kg EC significantly increased the serum level of FT3 but was significantly reduced by 6 g/kg EC, and finally, EC administrations did not have any significant effect on serum PSA. Methods: Thirty rats were used for the study, and were divided into six groups of five rats each. Group I animals served as normal control, group II animals served as vehicle control and were orally administered 6 mL/kg corn oil, while groups III, IV, V, and VI animals were orally administered 1, 2, 4, and 6 g/kg EC for seven days. Results: Following EC administrations, there was significant (p < 0.05) decrease in serum total cholesterol (TCHOL) by 4 and 6 g/kg body weight EC. Furthermore, luteinizing hormone (LH), testosterone (TST), and thyroid stimulating hormone (TSH) levels were significantly reduced by the various doses. Conversely, 2 and 4 g/kg EC significantly increased the serum level of free triiodothyronine (fT3), but was significantly reduced by 6 g/kg EC, and lastly, EC administrations did not have any significant effect on serum prostate specific antigen (PSA). Conclusion:We therefore concluded that the use of EC should be with caution, and may contribute to thyroid and hormonal disruption in rats. ARTICLE HISTORY

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Thyroid and reproductive hormones disruption as well as kallikrein-3 level in dimethyl nitrosamine-induced toxicity: Effects of ascorbate treatment in male wistar rats

et al. 2016

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Information on dimethyl nitrosamine (DMN)-induced toxicity on endocrine functions is still scanty. This study therefore investigated the outcomes of DMN-induced toxicity on endocrine (thyroid and reproductive) functions, as well as kallikrein-3 level, and effects of ascorbate treatments in male wistar rats. Thirty animals divided into six groups of five rats each were used. Group I animals were the normal control, group II animals served as vehicle control and were administered a single intraperitoneal dose of normal saline, groups III and IV were intraperitoneally injected with a single dose of 30 mg/kg DMN for 48 h, but group IV animals were post-treated orally with 5.71 mg/kg body weight (400 mg/70 kg) ascorbate for seven days, group V animals were pre-treated with same dose of ascorbate orally for seven days before intraperitoneal injection of DMN, while group VI animals were orally administered ascorbate only for seven days. Compared with control, DMN administration resulted in significant decrease (p < 0.05) in serum total cholesterol, testosterone (TST), luteinizing hormone (LH), free triiodothyronine (fT3), and kallikrein III (KLK-3) levels, as well as non-significant increase in serum thyroid stimulating hormone (TSH) level. Pre-treatment with ascorbate significantly increase LH and KLK-3 levels, while post-treatment significantly increase fT3 level. Also, pre-treatment with ascorbate significantly reduced TSH level, while there was no significant difference in TST level following ascorbate treatments. From our findings and to some extent, ascorbate demonstrates ameliorative effects against DMN-induced hormonal disruption in male wistar rats, and this may be attributed to its antioxidant property.

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Serum luteinising hormone, testosterone and total cholesterol levels, libido and testicular histomorphology of male West African Dwarf goats orally or subcutaneously treated with monosodium l-glutamate

Cited by 8 publications

References 19 publications

The effects of monosodium l-glutamate administration on the reproduction and serum biochemistry of adult male rabbits

The effects of monosodium l-glutamate administration on the reproduction and serum biochemistry of adult male rabbits

Effect of edible camphor administrations on levels of steroid and thyroid hormones in male wistar rats

Thyroid and reproductive hormones disruption as well as kallikrein-3 level in dimethyl nitrosamine-induced toxicity: Effects of ascorbate treatment in male wistar rats

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