Serum Lysozyme in Inflammatory Bowel Disease

Nugent, F. Warren; Mallari, Raymundo; George, Harvey; Ridley, Nancy

doi:10.1016/s0016-5085(76)80300-9

Cited by 11 publications

(4 citation statements)

References 15 publications

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“…More recently, gastroenterology has been added to this list with a report in which increased SLA was described in Crohn's disease and contrasted with normal activity in patients with ulcerative colitis (Falchuk et al, 1975). In subsequent studies, however, the absolute distinction of Crohn's disease patients from normal subjects and from those with ulcerative colitis has not been confirmed (Dronfield and Langman, 1975;Peeters et al, 1976;Nugent et al, 1976;Mallas et al, 1976).…”

mentioning

confidence: 99%

Complex nature of serum lysozyme activity: evidence of thermolability in inflammatory bowel disease.

Ward¹,

Mitchell²,

Eastwood³

1978

J Clin Pathol

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confidence: 99%

Complex nature of serum lysozyme activity: evidence of thermolability in inflammatory bowel disease.

Ward¹,

Mitchell²,

Eastwood³

1978

J Clin Pathol

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“…The serum proteins that have been suggested to be of diagnostic value in patients with Crohns disease and ulcerative colitis are haptoglobin and (XI-AG (22) and lysozyme (23). Other investigators, however, have not confirmed these results (9,24,25).…”

Section: Discussionmentioning

confidence: 97%

Acute Phase Proteins in Chronic Inflammatory Bowel Disease in Childhood

Campbell,

Walker‐Smith,

Hindocha

et al. 1982

J. pediatr. gastroenterol. nutr.

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The serum levels of five acute phase proteins (APP) were measured in 18 children with Crohn's Disease (CD) or ulcerative colitis (UC) and in two control groups. The levels of C‐reactive protein, α1‐acid glycoprotein, α1‐antitrypsin, C9, and Factor B were significantly raised in patients with CD and UC with good separation from controls, but they were not entirely reliable used as screening tests unless used in combination. The levels of APP were monitored for periods varying from 18 to 28 months in each patient and found to reflect the disease activity in both CD and UC. On seven occasions the APP levels did not match the clinically assessed disease activity, but when the serum levels were related to outcome of the disease. C‐reactive protein was found to be elevated—whether or not there were symptoms of the disease—in all patients who later had a relapse, while normal values were found in those who had a long remission. These results suggest that the estimation of C‐reactive protein is of prognostic value and that its measurement is particularly useful in children with mild symptoms in whom disease activity and prognosis are difficult to assess.

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“…Recently, slightly raised serum levels were reported in inflammatory bowel disease, and it was suggested that this may be of help in discriminating Crohn's disease from other forms (Falchuk et al, 1975). However, the latter finding has not been confirmed by subsequent workers (Dronfield and Langman, 1975;Mallas et al, 1976;Nugent et al, 1976;Peeters et al, 1976).…”

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confidence: 98%