Serum magnesium level in maintenance hemodialysis and cardiovascular calcification

Mansour, Howaida; Mohamed, Ragaa R.; Khaled, Manal F.; Khalil, Esraa M

doi:10.4103/sjamf.sjamf_14_18

Cited by 3 publications

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“…Other diseases such as volume expansion and diabetes could cause hypomagnesemia [5,6]. Numerous studies evaluated the hypomagnesemia in CKD, non-CKD, and ESRD patients and has been associated with increased cardiovascular mortality [7,8]. Hypomagnesemia has also been related to a rapid decrease rate of eGFR, however this has yet to be proven [9].…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Risk Factors and Impact of Proteinuria-Associated Hypomagnesemia in Chronic Kidney Disease Patients: A Cross Sectional Study

Jameel¹,

Farooq²,

Hashim³

et al. 2022

PJMHS

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Background and Aim: Chronic kidney disease (CKD) patients who have hypomagnesemia are at greater risk of mortality and progression. A limited amount of data is available on the prevalence of hypomagnesemia in kidney-related risk factors and chronic kidney disease patients. The present study aimed to assess the Proteinuria-associated hypomagnesemia in chronic renal disease patients: prevalence, risk factors, and effect. Patients and Method: This cross-sectional study was carried out on 128 chronic kidney disease patients in the Medicine Department of Shifa International Hospital, Rawalpindi from January 2022 to August 2022. Patients were categorized into two groups based on estimated glomerular filtration rate (eGFR) are as follows: group-I composed of Proteinuric and group-II non-proteinuric. Prior to study conduction, the ethical committee approved the protocol. Patients with prior history of ileostomy, malignancy, chronic diarrhea, colostomy, and using magnesium based medications were excluded. Detailed history, physical examination, and investigations such as serum total magnesium level (mg/dl), serum sodium level (mg/dl), serum creatinine (mg/dl), and total cholesterol and triglycerides (mg/dl) were recorded. Hypomagnesemia was defined as a serum magnesium level < 1.8 mg/dL. Results: Of the total 128 CKD patients, there were 66 (51.6%) male and 62 (48.4%) females. Group I and II had 64 patients each. The overall mean age of group-I and group-II was 48.82±12.52 and 48.21±10.64 years respectively. The prevalence of hypomagnesemia (<1.8 mg/dL) in the proteinuric group was 20 (31.3%). Diabetic patients are more susceptible to hypomagnesemia. The incidence of diabetic, hypertensive, and both diabetic and hypertensive was 12 (60%), 3 (15%), and 5 (25%) respectively among 20 hypomagnesemia. Hypomagnesemia patients had higher CRP (46 mg/L), UACR (2064 mg/g), lower serum potassium (56.4%), lower mean hemoglobin levels (10.2 g/dL), and lower serum sodium (34.9%) as compared to normomagnesemic patients 12 mg/L, 810 mg/g, 24.8%, 11.25 g/dL, and 8.6% respectively. Conclusion: The present study found that there is an independent association between hypomagnesemia and proteinuria in non-dialysis CKD patients. Anemia and hyperparathyroidism are risk factors for inflammation and anemia in CKD patients pre-dialysis. Dietary magnesium supplementation and hypomagnesemia correction may retard proteinuria and CKD progression in CKD patients. Keywords: Chronic kidney disease, Proteinuria-associated hypomagnesemia, Risk factors

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Section: Introductionmentioning

confidence: 99%

Prevalence, Risk Factors and Impact of Proteinuria-Associated Hypomagnesemia in Chronic Kidney Disease Patients: A Cross Sectional Study

Jameel¹,

Farooq²,

Hashim³

et al. 2022

PJMHS

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Evaluation of some blood minerals and its usefulness for follow-up and treatment hemodialysis patients

Attawi

Abdulwahid

2022

Materials Today: Proceedings

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Prevalence, risk factors and impact of proteinuria-associated hypomagnesemia in chronic kidney disease patients: cross-sectional study

et al. 2022

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Background Hypomagnesemia is a predictor of progression and mortality of chronic kidney disease (CKD) patients. However, limited data is available about the prevalence and kidney-related risk factors of hypomagnesemia in the CKD patients. We aimed to investigate the prevalence and risk factors of low serum magnesium level associated with proteinuria and its impact on CKD patients. This cross-sectional study enrolled 100 CKD patients with different stages according to estimated glomerular filtration rate (eGFR), divided into 2 groups (proteinuric and non-proteinuric) in the period from February 2020 to August 2020. Results The number of participants in this study was 100 subjects, 50 patients were proteinuric and 50 patients had no proteinuria. The study participants’ serum magnesium levels ranged from 1.2 to 2.7 mg/dL. Fourteen (28%) of proteinuric individuals had a serum magnesium level of less than 1.8 mg/dL. Hypomagnesemic patients had significantly higher urine albumin creatinine ratio (UACR) (2071 mg/g vs. 812 mg/g, P<0.001), significantly higher CRP (48 mg/L vs. 12 mg/L, P<0.001), and lower mean hemoglobin levels as well (10.4 g/dL vs. 10.91 g/dL, P= 0.044). Serum magnesium level showed negative correlation with UACR (r=−0.504, P<0.001), parathyroid hormone (r=−0.276, P=0.005), and CRP (r=−0.505, P<0.001). Conclusions Hypomagnesemia is a frequent electrolyte disorder in patients with CKD. Hypomagnesemia is independently associated with proteinuria. Hypomagnesemia is a risk factor of inflammation, anemia and hyperparathyroidism in pre-dialysis CKD population.

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Serum magnesium level in maintenance hemodialysis and cardiovascular calcification

Cited by 3 publications

References 0 publications

Prevalence, Risk Factors and Impact of Proteinuria-Associated Hypomagnesemia in Chronic Kidney Disease Patients: A Cross Sectional Study

Prevalence, Risk Factors and Impact of Proteinuria-Associated Hypomagnesemia in Chronic Kidney Disease Patients: A Cross Sectional Study

Evaluation of some blood minerals and its usefulness for follow-up and treatment hemodialysis patients

Prevalence, risk factors and impact of proteinuria-associated hypomagnesemia in chronic kidney disease patients: cross-sectional study

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