Serum Magnesium Levels in Acute Myocardial Infarction

Akila, A.; Anandaraj, J.; Karthikeyan, Srinivasan

doi:10.9790/0853-1605033540

Cited by 7 publications

(14 citation statements)

References 33 publications

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“…Akila et, al. 21 showed smoking, DM, HTN, CVD, Obesity, Dyslipidaemia are risk factors for cardiovascular disease whereas our study shown the similar result which supports our study. In another study conducted by Jaffrey, et al 20 showed similar risk factors HTN.…”

Section: Discussionsupporting

confidence: 91%

“…Whereas Nasim B, et al 8 , showed mean serum magnesium was 1.7-2.5 meq/ L(0.85-1.25 mmol/L) on the other hand Chowdhury, et al 18 showed it was 0.7±0.13 mmol/L. In different study conducted by Akila et al 21 and it was found serum magnesium level in hypomagnesemia group was 1.65±0.26 mg/dl(0.82±0.16 mmol/dl).…”

Section: Discussionmentioning

confidence: 93%

“…Sex incidence was also higher in Male than female. In different study conducted by Akila, et al 21 showed that male are predominance to hypomagnesemia than female and it male female ratio was 5.25:1. which supports our study.…”

Section: Discussionmentioning

confidence: 95%

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Association of low Serum Magnesium level with occurrence of Ventricular Arrhythmia in patients with Acute Myocardial Infarction

Uddin¹,

Chowdhury²,

Ahmed³

et al. 2020

Bangladesh Heart J

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Background: Acute Myocardial Infarction is the leading cause of morbidity and mortality throughout the world. Its prevalence among developing countries has increased significantly over the past two decades. Acute myocardial infarction is associated with electrolyte imbalance most commonly hypomagnesemia and hypokalaemia. Both are associated with ventricular arrhythmia which can lead to increase hospital mortality and morbidity. Objectives: To find out association of hypomagnesemia with ventricular arrhythmia in patients with acute myocardial infarction. Methods: Patients with acute myocardial infarction admitted in the department of Cardiology, DMCH, within the study period and who fulfilled the inclusion and exclusion criteria were taken as study sample. Informed consent was taken from all patients and then the patients were evaluated by detailed history, clinical examination and relevant investigations. Serum magnesium level was measured after admission. The sample population was Grouped into Group A(Acute myocardial infarction with normal serum magnesium) and Group B(Acute myocardial infarction with hypomagnesemia). Patients were followed up regularly till discharge or death for evidence of ventricular arrhythmia. Then the obtained data was analysed with SPSS 22.0. Results: Among 110 patients of Acute MI, 44 patients were in Group A who had plasma magnesium level e”0.7 mmol/ l and 66 patients were in Group B who had plasma magnesium level <0.7 mmol/l. Incidence of hypoagnesemia was 60% and more common in male. Male vs female percentage of hypomagnesemia were 61% vs 39%. Mean age was 54.16±11.72 yrs vs 57.52±10.59 yrs in group A vs group B. On admission serum magnesium level was 0.9218 vs 0.523 mmol/L( group A vs group B). The study showed that group B patients were more haemodynamically unstable and mean SBP and DBP were found 89.39±19.93 and 60.67±11.56 mm-Hg respectively. Troponin I was markedly increased in group B than A (i.e 4.7±1.79 vs 14.6±4.3 vs ng/ml). Adverse cardiac events such as cardiogenic shock (group A vs group B = 11.36% vs 28.27%) and ventricular arrhythmias(group A vs group B = 34% vs 72.73%) were also higher in group B than group A. Mean hospital stay for group B patient was higher than group A(6.78±0.85 vs 5.31±0.35 days). The study result showed that ventricular arrhythmia is negatively correlated with serum magnesium and the correlation coefficient was - 0.541. It also showed that serum Magnesium is positively correlated with Potassium(r= 0.831, p<0.01) and Calcium(r= 0.902, p<0.001). Multiple logistic regression analysis showed that hypomagnesemia is an independent risk factor for ventricular arrhythmia. Conclusions: This study showed that in patients with acute myocardial infarction, hypomagnesemia is common and it is significantly associated with ventricular arrhythmia. So the presence of hypomagnesemia should alert the physicians to adopt corrective measures as it increases both mortality and morbidity. Bangladesh Heart Journal 2020; 35(1) : 39-46

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 93%

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Association of low Serum Magnesium level with occurrence of Ventricular Arrhythmia in patients with Acute Myocardial Infarction

Uddin¹,

Chowdhury²,

Ahmed³

et al. 2020

Bangladesh Heart J

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“…Thus, significant difference was found in mean values between case and control groups. Some previous studies showed similar significant decrease in serum magnesium level of MI patient when compared with the corresponding control and it was clear that magnesium level of the MI groups was significantly lower than that of control groups 7,9,[12][13][14] .…”

Section: Resultsmentioning

confidence: 80%

Serum Magnesium in Acute Myocardial Infarction: Observation from Bangladeshi Patients

Quader

Rahman

Sultana³

et al. 2020

Faridpur Med Coll J

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Dyslipidemia is an established risk factor of acute myocardial infarction (AMI), but measurement of macro metals like magnesium can be helpful in the prevention and better management of AMI. The aim of this study was to estimate serum magnesium in AMI. This is a case control type of study carried out in the Department of Biochemistry, Dhaka Medical College, Dhaka during the period of January 2015 to December 2015 with a total number of 100 study subjects. Acute myocardial infarction patients were selected as case (50) from coronary care unit (CCU), Department of Cardiology, Dhaka Medical College Hospital. Normal healthy individuals were selected as control (50) from the attendants of patients, relatives and doctors. Serum level of magnesium were assessed for both case and control groups. The mean values of the variable were compared between them by statistical analysis using SPSS version 16. For all the statistical analysis P<0.05 was considered as significant. The mean values of serum magnesium were 1.63±0.27mg/dl in cases. The mean values of serum magnesium were 2.35±0.28 mg/dl in control group. Significant differences were found in mean values between case and control groups and differences were highly significant (p<0.001). In AMI, serum magnesium level was found to be lower in this study. Serum magnesium is an important trace element that act as cofactor in many biochemical reactions. Decrease level of this important trace element may contribute to pathogenesis of AMI. So with other biochemical risk parameters, routine assessment of serum magnesium level is advocated, which might be helpful for prevention and better management of AMI. Faridpur Med. Coll. J. Jul 2019;14(2): 71-73

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“…multifocal atrial tachycardia, ventricular fibrillation has been reported, and magnesium therapy has been suggested to improve the condition. 13,14 Further hypomagnesaemia has been found to be strongly associated with hypokalaemia leading to reduction in membrane ATPase activity with a loss of intracellular potassium and subsequent urinary loss. 15 Several studies have reported that hypokalaemia is associated with increased risk of ventricular arrhythmia leading to poor prognosis in acute myocardial infarction, although the exact mechanism is still unknown.…”

Section: Discussionmentioning

confidence: 99%

Presence of metabolic abnormalities in patients with acute myocardial infarction: at the onset and after recovery. A pilot study.

Bandopadhyay¹,

Ghosal²,

Batabyal³

2018

JDMDC

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Objective: To explore the interrelationship, if any, between acute myocardial infarction and metabolic abnormalities. Methodology: Forty six patients with acute myocardial infarction were selected and their blood was analysed for some key biochemical parameters. These parameters were analysed again after three weeks in twenty-two patients who recovered and were discharged from the hospital. For comparison, twenty adult individuals were selected as normal controls. Results: Altered glucose and lipid parameters, along with raised serum uric acid & calcium and reduced levels of serum magnesium & potassium, were found during acute myocardial infarction. In the recovery phase, the metabolic changes did not improve in spite of significant clinical improvements. Out of all the parameters, triglyceride/ high density lipoprotein cholesterol ratio was found to be a stable biomarker for acute myocardial infarction. Patients with acute myocardial infarction with elevated TG/ HDL-C ratio could represent a high-risk group requiring aggressive intervention. Conclusion: Our pilot study indicates that a larger epidemiological study should be conducted in patients with acute myocardial infarction using TG/HDL-C ratio as a biomarker of interest, and finding an appropriate cutoff value for the same.

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Serum Magnesium Levels in Acute Myocardial Infarction

Cited by 7 publications

References 33 publications

Association of low Serum Magnesium level with occurrence of Ventricular Arrhythmia in patients with Acute Myocardial Infarction

Association of low Serum Magnesium level with occurrence of Ventricular Arrhythmia in patients with Acute Myocardial Infarction

Serum Magnesium in Acute Myocardial Infarction: Observation from Bangladeshi Patients

Presence of metabolic abnormalities in patients with acute myocardial infarction: at the onset and after recovery. A pilot study.

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