Serum magnesium levels in preterm labour

Abstract

Introduction: Preterm infants are at a greater risk of short term and long term complications including disabilities and impediments in growth and mental development. Hence, to predict and prevent the occurrence of preterm labour and delivery would go a long way to reduce the morbidity and mortality resulting from it. Preterm labour followed by preterm delivery is a major issue in India. Besides various etiologies, preterm labour may be due to a biochemical alteration, such as magnesium. Many recent findings have augmented the significance of magnesium in human health and disease. There is a mounting evidence that alterations in magnesium metabolism have a negative impact on pregnancy outcome. The aim of our investigation was to study the serum magnesium levels in preterm labour and to compare these values with those patients who had a term delivery, to find associated signs and symptoms and to suggest nutritional correction of prognostic value. Methods: A case-control study was carried out to evaluate serum magnesium levels and associated symptoms in women with preterm labour (28-36 weeks) and compare them with patients in same gestational age who delivered at term (37-40 weeks). Results: Patients in preterm labour have a significantly depressed serum magnesium level [mean, 1.343±0.09 meq/lvs 1.875±0.013 meq/l] (p<0.001) as compared to normal pregnancy. Preterm labour cases differed from controls in terms of significantly higher incidence of muscle cramps and change in the quality or quantity of vaginal discharge (p<0.001). In our study, fall in the value of

Maternal Magnesium Level Effect on Preterm Labor Treatment

“…In their study, Bhat and Waheed evaluated the relationship between socio-economic class and preterm labor and found a significant association between low socio-economic class and preterm labor (P < 0.05) (31). They also found a significant difference in serum magnesium level between 3 groups of high, medium, and low socio-economic classes.…”

Preterm Labour;

“…Numerous new studies have highlighted the importance of magnesium in human biology. 11 There is proof that changes and alterations in magnesium metabolism have an undesirable effect on pregnancy and its outcome. Another study 15 showed that women with preterm labor have proportionally low serum magnesium levels (60%) compared to women having normal labor (32%).…”

Preterm Labour

“…Numerous new studies have highlighted the importance of magnesium in human biology. 11 There is proof that changes and alterations in magnesium metabolism have an undesirable effect on pregnancy and its outcome.…”