2017
DOI: 10.3390/nu9101125
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Serum Magnesium Levels in Preterm Infants Are Higher Than Adult Levels: A Systematic Literature Review and Meta-Analysis

Abstract: Magnesium (Mg) is an essential mineral in the body, impacting the synthesis of biomacromolecules, bone matrix development, energy production, as well as heart, nerve, and muscle function. Although the importance of Mg is evident, reference values for serum Mg (sMg) in pediatric patients (more specifically, in neonates) are not well established. This systematic literature review and meta-analysis (using 47 eligible studies) aims to quantify normal and tolerable ranges of sMg concentrations during the neonatal p… Show more

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Cited by 38 publications
(32 citation statements)
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References 110 publications
(214 reference statements)
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“…Moreover, magnesium sulphate has been shown to decrease the production of free radicals and proinflammatory cytokines during reperfusion after ischemia or inflammation . Magnesium's anti‐inflammatory properties are also observed in vitro in cord blood mononuclear cells of the human neonate .…”
Section: Mechanisms Involved In the Neuroprotective Effects Of Magnesmentioning
confidence: 99%
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“…Moreover, magnesium sulphate has been shown to decrease the production of free radicals and proinflammatory cytokines during reperfusion after ischemia or inflammation . Magnesium's anti‐inflammatory properties are also observed in vitro in cord blood mononuclear cells of the human neonate .…”
Section: Mechanisms Involved In the Neuroprotective Effects Of Magnesmentioning
confidence: 99%
“…With maternal magnesium supplementation during pregnancy, the average concentration becomes 1.25mmol/L (95% CI: 0.47, 2.03) at birth and 1.48mmol/L (95% CI: 0.64, 2.32) on the first day after birth. Serum magnesium concentrations up to 2.0mmol/L appear to be well tolerated in neonates; administration requires adequate surveillance but minimal intervention …”
Section: Magnesium: Biological Perspectivesmentioning
confidence: 99%
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“…Upper and lower quintiles were chosen as the cutoff levels represent clinically significant magnesium levels in the neonate. 13 The primary outcomes were the rate of any NEC, severe NEC (Bell's Stage II or III), bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), respiratory distress syndrome (RDS), neonatal hypotension in the delivery room, or definite neonatal sepsis. Secondary outcomes were neurologic outcomes including, any CP at age 2 years, moderate to severe CP, severe intraventricular hemorrhage (IVH), mental disability index (MDI), or physical disability index (PDI) score less than 70 on the Bayley Scales of Infant Development II administered at the 2-year examination, or death.…”
mentioning
confidence: 99%